北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科  > 期刊论文
学科主题: 临床医学
题名:
Dosimetric Study of Cs-131, I-125, and Pd-103 Seeds for Permanent Prostate Brachytherapy
作者: Yang, Ruijie1; Wang, Junjie1; Zhang, Hongzhi2
关键词: prostate neoplasms/brachytherapy ; permanent implant ; dosimetry ; cesium-131 ; iodine-125 ; polodium-103
刊名: CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
发表日期: 2009-12-01
DOI: 10.1089/cbr.2009.0648
卷: 24, 期:6, 页:701-705
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Research & Experimental Medicine ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: POSTIMPLANT DOSIMETRY ; CANCER ; IMPLANTS ; OUTCOMES ; EDEMA ; ALPHA/BETA ; ISOTOPE ; IMPACT ; MODEL ; TRIAL
英文摘要:

As a well-established single-modality approach for early-stage prostate cancer, transperineal interstitial permanent prostate brachytherapy (TIPPB) has gained increasing popularity due to its favorable clinical results. Currently, three isotopes, namely Cs-131, I-125, and Pd-103, are commercially available for TIPPB. This is the first study to systematically explore the dosimetric difference of these three isotopes for TIPPB. In total, 25 patients with T1-T2c prostate cancer previously implanted with I-125 seeds were randomly selected and replanned with Cs-131, I-125, and Pd-103 seeds to the prescription doses of 115, 145, and 125 Gy, respectively. The planning goals attempted were prostate V(p)100 similar to 95%, D(p)90 >= 100%, and prostatic urethra D(u)10 <= 150%. The dosimetric parameters, as well as the number of seeds and needles required, were analyzed and compared. The mean homogeneity index (HI) was 0.59, 0.56, and 0.46 for Cs-131, I-125, and Pd-103 plans, respectively. The average D(u)10 was 124.6%, 125.7%, and 129.7%, respectively. The average rectum V(r)100 was 0.19, 0.22, and 0.31 cc, respectively. In addition, the average number of seeds was 57.9, 63.0, and 63.7, and the average number of needles required was 31.6, 32.9, and 33.6 for Cs-131, I-125, and Pd-103 seeds, respectively. This study demonstrates that TIPPB, utilizing Cs-131 seeds, allows for better dose homogeneity, while providing comparable prostate coverage and sparing of the urethra and rectum, with a comparable number of, or fewer, seeds and needles required, compared to I-125 or Pd-103 seeds. Further biological and clinical studies associated with Cs-131 are warranted.

语种: 英语
WOS记录号: WOS:000272955600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52435
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Radiat Oncol, Ctr Canc, Hosp 3, Beijing 100191, Peoples R China
2.Peking Union Med Coll, Chinese Acad Med Sci, Canc Inst Hosp, Dept Radiat Oncol, Beijing 100021, Peoples R China

Recommended Citation:
Yang, Ruijie,Wang, Junjie,Zhang, Hongzhi. Dosimetric Study of Cs-131, I-125, and Pd-103 Seeds for Permanent Prostate Brachytherapy[J]. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS,2009,24(6):701-705.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Ruijie]'s Articles
[Wang, Junjie]'s Articles
[Zhang, Hongzhi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Ruijie]‘s Articles
[Wang, Junjie]‘s Articles
[Zhang, Hongzhi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace