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Triptolide regulates T cell-mediated immunity via induction of CD11c(low) dendritic cell differentiation
Yan, Yong-hong1; Shang, Pei-zhong1; Lu, Qing-jun1; Wu, Xu2
关键词Triptolide Dendritic Cell Cd11c(High) Dcs Cd11c(Low) Dcs Immunity
刊名FOOD AND CHEMICAL TOXICOLOGY
2012-07-01
DOI10.1016/j.fct.2012.04.033
50期:7页:2560-2564
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology ; Toxicology
研究领域[WOS]Food Science & Technology ; Toxicology
关键词[WOS]WILFORDII HOOK-F ; TRIPTERYGIUM ; ACTIVATION ; PHOSPHORYLATION ; EXPRESSION
英文摘要

Triptolide(TPT) isolated from one of the Chinese herbs, Tripterygium wilfordii Hook. F. (TWHF), are known to have a variety of immunomodulatory activities. This study was performed to investigate the effect of TPT on the differentiation of splenic DCs and its influence on T cell-mediated immunity regarding to DC subsets CD11c(low)I-a/e(low)CD45RB(+)(CD11c(low) DCs) and CD11c(high)I-a/e(high)CD45RB(-) (CD11c(high) DCs) in male C57BL/6 mice spleens in vitro. The percentage of CD11c(low) DCs was significantly increased after treatment with TPT compared to their counterparts (CD11c(high) DCs). It was found that unlike the gradually decreasing interleukin (IL)-12 secretion of CD11c(high) DCs induced by TPT, CD11c(low) DCs showed a obvious dose-dependent response between the increasing of IL-10 production and TPT stimulation. After treatment with anti-IL-12R or anti-IL-10 monoclonal antibody in CD4(+) T cells + CD11c(high) DCs or CD11c(low) DCs mixed lymphocyte reaction, the induction of these DCs on T cells was inhibited dramatically. These data demonstrated that TPT might induce the differentiation of splenic DCs to CD11c(low) DCs followed by shifting of Th1 to Th2 with enhancement of T lymphocyte immune function in vitro. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000307320200042
项目编号2010gxjs010
资助机构New and Hi-tech clinical key projects in millitary hospitals
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52446
专题北京大学第一临床医学院
作者单位1.251 Hosp PLA, Dept Burn, Zhangjiakou 075000, Hebei, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
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GB/T 7714
Yan, Yong-hong,Shang, Pei-zhong,Lu, Qing-jun,et al. Triptolide regulates T cell-mediated immunity via induction of CD11c(low) dendritic cell differentiation[J]. FOOD AND CHEMICAL TOXICOLOGY,2012,50(7):2560-2564.
APA Yan, Yong-hong,Shang, Pei-zhong,Lu, Qing-jun,&Wu, Xu.(2012).Triptolide regulates T cell-mediated immunity via induction of CD11c(low) dendritic cell differentiation.FOOD AND CHEMICAL TOXICOLOGY,50(7),2560-2564.
MLA Yan, Yong-hong,et al."Triptolide regulates T cell-mediated immunity via induction of CD11c(low) dendritic cell differentiation".FOOD AND CHEMICAL TOXICOLOGY 50.7(2012):2560-2564.
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