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学科主题: 临床医学
题名:
Triptolide regulates T cell-mediated immunity via induction of CD11c(low) dendritic cell differentiation
作者: Yan, Yong-hong1; Shang, Pei-zhong1; Lu, Qing-jun1; Wu, Xu2
关键词: Triptolide ; Dendritic cell ; CD11c(high) DCs ; CD11c(low) DCs ; Immunity
刊名: FOOD AND CHEMICAL TOXICOLOGY
发表日期: 2012-07-01
DOI: 10.1016/j.fct.2012.04.033
卷: 50, 期:7, 页:2560-2564
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology ; Toxicology
研究领域[WOS]: Food Science & Technology ; Toxicology
关键词[WOS]: WILFORDII HOOK-F ; TRIPTERYGIUM ; ACTIVATION ; PHOSPHORYLATION ; EXPRESSION
英文摘要:

Triptolide(TPT) isolated from one of the Chinese herbs, Tripterygium wilfordii Hook. F. (TWHF), are known to have a variety of immunomodulatory activities. This study was performed to investigate the effect of TPT on the differentiation of splenic DCs and its influence on T cell-mediated immunity regarding to DC subsets CD11c(low)I-a/e(low)CD45RB(+)(CD11c(low) DCs) and CD11c(high)I-a/e(high)CD45RB(-) (CD11c(high) DCs) in male C57BL/6 mice spleens in vitro. The percentage of CD11c(low) DCs was significantly increased after treatment with TPT compared to their counterparts (CD11c(high) DCs). It was found that unlike the gradually decreasing interleukin (IL)-12 secretion of CD11c(high) DCs induced by TPT, CD11c(low) DCs showed a obvious dose-dependent response between the increasing of IL-10 production and TPT stimulation. After treatment with anti-IL-12R or anti-IL-10 monoclonal antibody in CD4(+) T cells + CD11c(high) DCs or CD11c(low) DCs mixed lymphocyte reaction, the induction of these DCs on T cells was inhibited dramatically. These data demonstrated that TPT might induce the differentiation of splenic DCs to CD11c(low) DCs followed by shifting of Th1 to Th2 with enhancement of T lymphocyte immune function in vitro. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2010gxjs010
项目资助者: New and Hi-tech clinical key projects in millitary hospitals
WOS记录号: WOS:000307320200042
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52446
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.251 Hosp PLA, Dept Burn, Zhangjiakou 075000, Hebei, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China

Recommended Citation:
Yan, Yong-hong,Shang, Pei-zhong,Lu, Qing-jun,et al. Triptolide regulates T cell-mediated immunity via induction of CD11c(low) dendritic cell differentiation[J]. FOOD AND CHEMICAL TOXICOLOGY,2012,50(7):2560-2564.
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