北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Plasma Copeptin and Therapeutic Effectiveness of Midodrine Hydrochloride on Postural Tachycardia Syndrome in Children
作者: Zhao, Juan1; Tang, Chaoshu2,3; Jin, Hongfang1; Du, Junbao1
刊名: JOURNAL OF PEDIATRICS
发表日期: 2014-08-01
DOI: 10.1016/j.jpeds.2014.04.032
卷: 165, 期:2, 页:290-294
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pediatrics
研究领域[WOS]: Pediatrics
关键词[WOS]: VASOPRESSIN PRECURSOR ; PIG PITUITARIES ; POSTERIOR LOBE ; SYNCOPE ; GLYCOPEPTIDE ; DIAGNOSIS ; SYSTEM
英文摘要:

Objectives Midodrine hydrochloride is used clinically to treat children with postural tachycardia syndrome (POTS), but it is not effective in all patients. This study was designed to explore the changes in plasma copeptin and its predictive value in assessing the therapeutic efficacy of midodrine hydrochloride in children with POTS.

Study design The study included 33 children with POTS and 26 healthy children. The group with POTS received midodrine hydrochloride treatment for 1.5-3 months. The plasma copeptin was measured using a sandwich immunoluminometric assay. A receiver operating characteristic curve was used to explore the predictive value of plasma copeptin.

Results The plasma copeptin in the group with POTS was significantly higher than that of the control group (10.827 +/- 2.459 pmol/L vs 8.845 +/- 1.471 pmol/L, P < .001). The plasma copeptin in responders to midodrine hydrochloride was significantly higher than that of nonresponders (12.082 +/- 1.998 pmol/L vs 9.646 +/- 2.301 pmol/L, P = .003). Receiver operating characteristic analysis on the predictive value of plasma copeptin showed that the area under the curve was 0.800 with a 95% CI of 0.640-0.959. Using a plasma copeptin level of 10.482 pmol/L as the cutoff point produced both favorite sensitivity (81.3%) and specificity (76.5%) in predicting the efficacy of midodrine hydrochloride therapy in children with POTS.

Conclusions Plasma copeptin may be considered as a predictive biomarker for the likelihood of successful treatment of children with POTS with midodrine hydrochloride.

语种: 英语
所属项目编号: 2012BAI03B03 ; 2012CB517806 ; 2011CB503904 ; 81121061
项目资助者: National Twelfth Five-Year Plan for Science and Technology Support ; Major Basic Research Project of China ; National Natural Science Foundation of China
WOS记录号: WOS:000341435800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52447
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Minist Educ, Key Lab Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China

Recommended Citation:
Zhao, Juan,Tang, Chaoshu,Jin, Hongfang,et al. Plasma Copeptin and Therapeutic Effectiveness of Midodrine Hydrochloride on Postural Tachycardia Syndrome in Children[J]. JOURNAL OF PEDIATRICS,2014,165(2):290-294.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Juan]'s Articles
[Tang, Chaoshu]'s Articles
[Jin, Hongfang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Juan]‘s Articles
[Tang, Chaoshu]‘s Articles
[Jin, Hongfang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace