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学科主题: 基础医学
题名:
Cross-talk of oploid peptide receptor and beta-adrenergic receptor signalling in the heart
作者: Pepe, S1; van den Brink, OWV1; Lakatta, EG1; Xiao, RP1
关键词: G protein-coupled receptors ; beta-adrenergic receptors ; opioid peptide receptors ; receptor dimerization ; cardiac contractility ; cardiac preconditioning
刊名: CARDIOVASCULAR RESEARCH
发表日期: 2004-08-15
DOI: 10.1016/j.cardiores.2004.04.022
卷: 63, 期:3, 页:414-422
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: PROTEIN-KINASE-C ; DELTA-OPIOID RECEPTOR ; RAT VENTRICULAR MYOCYTES ; K-ATP CHANNELS ; PRIMARY HEREDITARY CARDIOMYOPATHY ; PREPROENKEPHALIN MESSENGER-RNA ; PRODYNORPHIN GENE-EXPRESSION ; SENSITIVE POTASSIUM CHANNELS ; EMBRYONIC STEM-CELLS ; CARDIAC MYOCYTES
英文摘要:

Opioid peptide receptor (OPR) and beta-adrenergic receptor (beta-AR) are well-established members of G-protein-coupled receptor (GPCR) superfamily and are involved in regulating cardiac contractility, energy metabolism, myocyte survival or death. OPRs are typical G(i)/G(o)-coupled receptors and activated by opioid peptides derived from the endorphin, dynorphin and enkephalin families, whereas beta-AR stimulated by catecholamines is the model system for G(s)-coupled receptors. While it is widely accepted that beta-AR stimulation serves as the most powerful means to increase cardiac output in response to stress or exercise, we have only begun to appreciate functional roles of OPR stimulation in regulating cardiovascular performance. Cardiovascular regulatory effects of endogenous opioids were initially considered to originate from the central nervous system and involved the pre-synaptic co-release of norepinephrine with enkephalin from sympathetic neuronal terminals in the heart. However, opioid peptides of myocardial origin have been shown to play important roles in local regulation of the heart. Notably, OPR stimulation not only inhibits cardiac excitation-contraction coupling, but also protects the heart against hypoxic and ischemic injury via activation of G(i)-mediated signalling pathways. Further, OPRs functionally and physically cross-talk with beta-ARs via multiple hierarchical mechanisms, including heterodimerization of these receptors, counterbalance of functional opposing G protein signalling, and interface at downstream signalling events. As a result, the beta-AR-mediated positive inotropic effect and increase in cAMP are markedly attenuated by OPR activation in isolated cardiomyocytes as well as sympathectomized intact rat hearts. This brief review will focus on the interaction between beta-AR and OPR and its potential physiological and pathophysiological relevance in the heart. (C) 2004 European Society of Cardiology. Published by Elsevier B.V.

语种: 英语
WOS记录号: WOS:000223241600006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52450
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.NIA, Cardiovasc Sci Lab, Ctr Gerontol Res, NIH, Baltimore, MD 21224 USA
3.Baker Heart Res Inst, Lab Cardiac Surg Res, Wynn Domain, Melbourne, Vic, Australia
4.Monash Univ, Fac Med, Alfred Hosp, Melbourne, Vic 3004, Australia
5.Peking Univ, Inst Cardiovasc Sci, Beijing 100871, Peoples R China

Recommended Citation:
Pepe, S,van den Brink, OWV,Lakatta, EG,et al. Cross-talk of oploid peptide receptor and beta-adrenergic receptor signalling in the heart[J]. CARDIOVASCULAR RESEARCH,2004,63(3):414-422.
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