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学科主题口腔医学
Initial Periodontal Therapy Reduced Systemic and Local 25-Hydroxy Vitamin D-3 and Interleukin-1 beta in Patients With Aggressive Periodontitis
Liu, Kaining; Meng, Huanxin; Lu, Ruifang; Xu, Li; Zhang, Li; Chen, Zhibin; Shi, Dong; Feng, Xianghui; Tang, Xiaolin
关键词Aggressive Periodontitis Gingival Crevicular Fluid Plasma
刊名JOURNAL OF PERIODONTOLOGY
2010-02-01
DOI10.1902/jop.2009.090355
81期:2页:260-266
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者National Natural Science Foundations of China, Beijing, China ; National Key Project of Scientific and Technical Supporting Programs of China, Beijing, China ; National Natural Science Foundations of China, Beijing, China ; National Key Project of Scientific and Technical Supporting Programs of China, Beijing, China
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]GINGIVAL CREVICULAR FLUID ; BONE TURNOVER ; IL-1-BETA ; ANALOGS ; MARKERS ; CELLS ; DIFFERENTIATION ; OSTEOCALCIN ; METABOLISM ; EXPRESSION
英文摘要

Background: 25-hydroxy vitamin D-3 is the major circulating metabolite of vitamin D. Elevated plasma 25-hydroxy vitamin D-3 levels were verified to be associated with generalized aggressive periodontitis (GAgP). In the present study, the influence of initial periodontal therapy on systemic and local levels of 25-hydroxy vitamin D-3 and three related elements (osteocalcin and interleukin-1 beta and -6) in patients with GAgP was investigated.

Methods: Nineteen patients with GAgP were enrolled. All patients received initial periodontal therapy. Gingival crevicular fluid at two sites of each subject were obtained before therapy and 2 and 6 months after therapy. Plasma was obtained before and 2 months after therapy from 12 of 19 subjects. Systemic and local levels of 25-hydroxy vitamin D-3, osteocalcin, and interleukin-1 beta and -6 before and after therapy were measured using radioimmunoassay or enzyme-linked immuno-sorbent assay kits and compared.

Results: The respective systemic 25-hydroxy vitamin D-3 and interleukin-1 beta levels significantly dropped from baseline to 2 months after therapy (29.28 nmol/l versus 22.50 nmol/l, P = 0.001, and 6.71 ng/l versus 3.23 ng/l, P < 0.001, respectively). The respective local 25-hydroxy vitamin D-3 and interleukin-1 beta levels significantly decreased from baseline to 2 and 6 months after therapy (8,950 nmol/lversus 5,650 nmol/lversus 3,438 nmol/l, P < 0.001, and 10,595 ng/l versus 5,495 ng/l versus 3,960 ng/l, P < 0.001, respectively). Systemic and local 25-hydroxy vitamin D-3 concentrations were positively correlated at baseline (r = 0.877; P = 0.022), as was osteocalcin (r = 0.939; P = 0.005).

Conclusions: 25-hydroxy vitamin D-3 and interleukin-1 beta levels were systemically and locally reduced in patients with GAgP by initial periodontal therapy. 25-hydroxy vitamin D-3 might be involved in periodontal inflammation. J Periodontol 2010;81:260-266.

语种英语
所属项目编号30471882 ; 30772420 ; 2007BAZ18B02
资助者National Natural Science Foundations of China, Beijing, China ; National Key Project of Scientific and Technical Supporting Programs of China, Beijing, China ; National Natural Science Foundations of China, Beijing, China ; National Key Project of Scientific and Technical Supporting Programs of China, Beijing, China
WOS记录号WOS:000283020300012
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52451
Collection北京大学口腔医学院_牙周科
作者单位Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Liu, Kaining,Meng, Huanxin,Lu, Ruifang,et al. Initial Periodontal Therapy Reduced Systemic and Local 25-Hydroxy Vitamin D-3 and Interleukin-1 beta in Patients With Aggressive Periodontitis[J]. JOURNAL OF PERIODONTOLOGY,2010,81(2):260-266.
APA Liu, Kaining.,Meng, Huanxin.,Lu, Ruifang.,Xu, Li.,Zhang, Li.,...&Tang, Xiaolin.(2010).Initial Periodontal Therapy Reduced Systemic and Local 25-Hydroxy Vitamin D-3 and Interleukin-1 beta in Patients With Aggressive Periodontitis.JOURNAL OF PERIODONTOLOGY,81(2),260-266.
MLA Liu, Kaining,et al."Initial Periodontal Therapy Reduced Systemic and Local 25-Hydroxy Vitamin D-3 and Interleukin-1 beta in Patients With Aggressive Periodontitis".JOURNAL OF PERIODONTOLOGY 81.2(2010):260-266.
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