北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 化学生物学系  > 期刊论文
学科主题: 药学
题名:
Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury
作者: Ning, Xianling1; Guo, Ying1; Ma, Xiaoyan1; Zhu, Renzong1; Tian, Chao1; Zhang, Zhili1; Wang, Xiaowei1; Ma, Zhizhong3; Liu, Junyi1,2
关键词: (E)-3,4-Dihydroxy styryl sulfonamides ; Caffeic acid phenethyl ester ; Neuroprotective agents ; Antioxidants ; Blood brain barrier permeability
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
发表日期: 2013-09-01
DOI: 10.1016/j.bmc.2013.05.043
卷: 21, 期:17, 页:5589-5597
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: ACID PHENETHYL ESTER ; FACTOR-KAPPA-B ; HYDROGEN-PEROXIDE ; NEURODEGENERATIVE DISEASES ; ANTIOXIDANT PROPERTIES ; ARTIFICIAL MEMBRANE ; IN-VITRO ; CELLS ; INHIBITORS ; PROPOLIS
英文摘要:

A novel class of (E)-3,4-dihydroxy styryl sulfonamides and their 3,4-diacetylated derivatives as caffeic acid phenethyl ester (CAPE) analogs was designed and prepared for improving stability and solubility of the lead compound. Their neuroprotective properties were assessed by several models. The results showed that target compounds displayed positive free radical quenching abilities, superior to that of CAPE. Compounds 6j-k and 7j-k demonstrated remarkable protection effects against damage induced by hydrogen peroxide which were apparently stronger than that of CAPE. Most of target compounds could inhibit nitric oxide production. Additionally, target compounds showed high blood-brain barrier permeability. (C) 2013 Published by Elsevier Ltd.

语种: 英语
所属项目编号: 20972011 ; 21042009 ; 21172014 ; 2009ZX09301-010
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000323294600077
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52457
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China

Recommended Citation:
Ning, Xianling,Guo, Ying,Ma, Xiaoyan,et al. Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2013,21(17):5589-5597.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ning, Xianling]'s Articles
[Guo, Ying]'s Articles
[Ma, Xiaoyan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ning, Xianling]‘s Articles
[Guo, Ying]‘s Articles
[Ma, Xiaoyan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace