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Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury
Ning, Xianling1; Guo, Ying1; Ma, Xiaoyan1; Zhu, Renzong1; Tian, Chao1; Zhang, Zhili1; Wang, Xiaowei1; Ma, Zhizhong3; Liu, Junyi1,2
关键词Caffeic Acid Phenethyl Ester (e)-3 Neuroprotective Agents 4-dihydroxy Styryl Sulfonamides Antioxidants Blood Brain Barrier Permeability
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2013-09-01
DOI10.1016/j.bmc.2013.05.043
21期:17页:5589-5597
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ACID PHENETHYL ESTER ; FACTOR-KAPPA-B ; HYDROGEN-PEROXIDE ; NEURODEGENERATIVE DISEASES ; ANTIOXIDANT PROPERTIES ; ARTIFICIAL MEMBRANE ; IN-VITRO ; CELLS ; INHIBITORS ; PROPOLIS
英文摘要

A novel class of (E)-3,4-dihydroxy styryl sulfonamides and their 3,4-diacetylated derivatives as caffeic acid phenethyl ester (CAPE) analogs was designed and prepared for improving stability and solubility of the lead compound. Their neuroprotective properties were assessed by several models. The results showed that target compounds displayed positive free radical quenching abilities, superior to that of CAPE. Compounds 6j-k and 7j-k demonstrated remarkable protection effects against damage induced by hydrogen peroxide which were apparently stronger than that of CAPE. Most of target compounds could inhibit nitric oxide production. Additionally, target compounds showed high blood-brain barrier permeability. (C) 2013 Published by Elsevier Ltd.

语种英语
WOS记录号WOS:000323294600077
项目编号20972011 ; 21042009 ; 21172014 ; 2009ZX09301-010
资助机构National Natural Science Foundation of China ; Ministry of Science and Technology of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52457
专题北京大学药学院_化学生物学系
北京大学基础医学院
北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ning, Xianling,Guo, Ying,Ma, Xiaoyan,et al. Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2013,21(17):5589-5597.
APA Ning, Xianling.,Guo, Ying.,Ma, Xiaoyan.,Zhu, Renzong.,Tian, Chao.,...&Liu, Junyi.(2013).Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury.BIOORGANIC & MEDICINAL CHEMISTRY,21(17),5589-5597.
MLA Ning, Xianling,et al."Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury".BIOORGANIC & MEDICINAL CHEMISTRY 21.17(2013):5589-5597.
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