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学科主题: 临床医学
题名:
The message in the air: Hydrogen sulfide metabolism in chronic respiratory diseases
作者: Chen, Yahong2; Wang, Rui1
关键词: Hydrogen sulfide ; Asthma ; Chronic respiratory diseases
刊名: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
发表日期: 2012-11-15
DOI: 10.1016/j.resp.2012.03.009
卷: 184, 期:2, 页:130-138
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Physiology ; Respiratory System
研究领域[WOS]: Physiology ; Respiratory System
关键词[WOS]: 1-MEDIATED NEUROGENIC INFLAMMATION ; OBSTRUCTIVE PULMONARY-DISEASE ; EXHALED NITRIC-OXIDE ; CLINICAL-PRACTICE ; HYPERBARIC-OXYGEN ; TRACT INFECTIONS ; CYSTIC-FIBROSIS ; GLOBAL STRATEGY ; CARBON-MONOXIDE ; SMOOTH-MUSCLE
英文摘要:

Hydrogen sulfide (H2S) is an important gasotransmitter in the mammalian respiratory system. The enzymes that produce H2S mainly cystathionine-beta-synthase and cystathionine-gamma-lyase - are expressed in pulmonary and airway tissues. Endogenous H2S participates in the regulation of the respiratory system′s physiological functions and pathophysiological alterations, such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and hypoxia-induced pulmonary hypertension, to name a few. The cellular targets of H2S in the respiratory system are diverse, including airway smooth muscle cells, epithelial cells, fibroblasts, and pulmonary artery smooth muscle cells. H2S also regulates respiratory functions such as airway constriction, pulmonary circulation, cell proliferation or apoptosis, fibrosis, oxidative stress, and neurogenic inflammation. Cross-talk between H2S and other gasotransmitters also affects the net outcome of lung function. The metabolism of H2S in the lungs and airway may serve as a biomarker for specific respiratory diseases. It is expected that strategies targeted at the metabolism and function of H2S will prove useful for the prevention and treatment of selective chronic respiratory diseases. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
项目资助者: American Asthma Foundation
WOS记录号: WOS:000311258500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52460
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Resp Dept, Beijing 100871, Peoples R China
2.Lakehead Univ, Off VP Res, Dept Biol, Thunder Bay, ON P7B 5E1, Canada

Recommended Citation:
Chen, Yahong,Wang, Rui. The message in the air: Hydrogen sulfide metabolism in chronic respiratory diseases[J]. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY,2012,184(2):130-138.
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