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The message in the air: Hydrogen sulfide metabolism in chronic respiratory diseases
Chen, Yahong2; Wang, Rui1
关键词Hydrogen Sulfide Asthma Chronic Respiratory Diseases
刊名RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
2012-11-15
DOI10.1016/j.resp.2012.03.009
184期:2页:130-138
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Physiology ; Respiratory System
研究领域[WOS]Physiology ; Respiratory System
关键词[WOS]1-MEDIATED NEUROGENIC INFLAMMATION ; OBSTRUCTIVE PULMONARY-DISEASE ; EXHALED NITRIC-OXIDE ; CLINICAL-PRACTICE ; HYPERBARIC-OXYGEN ; TRACT INFECTIONS ; CYSTIC-FIBROSIS ; GLOBAL STRATEGY ; CARBON-MONOXIDE ; SMOOTH-MUSCLE
英文摘要

Hydrogen sulfide (H2S) is an important gasotransmitter in the mammalian respiratory system. The enzymes that produce H2S mainly cystathionine-beta-synthase and cystathionine-gamma-lyase - are expressed in pulmonary and airway tissues. Endogenous H2S participates in the regulation of the respiratory system′s physiological functions and pathophysiological alterations, such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and hypoxia-induced pulmonary hypertension, to name a few. The cellular targets of H2S in the respiratory system are diverse, including airway smooth muscle cells, epithelial cells, fibroblasts, and pulmonary artery smooth muscle cells. H2S also regulates respiratory functions such as airway constriction, pulmonary circulation, cell proliferation or apoptosis, fibrosis, oxidative stress, and neurogenic inflammation. Cross-talk between H2S and other gasotransmitters also affects the net outcome of lung function. The metabolism of H2S in the lungs and airway may serve as a biomarker for specific respiratory diseases. It is expected that strategies targeted at the metabolism and function of H2S will prove useful for the prevention and treatment of selective chronic respiratory diseases. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000311258500003
资助机构American Asthma Foundation
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52460
专题北京大学第三临床医学院_呼吸科
北京大学第二临床医学院_重症医学科
作者单位1.Peking Univ, Hosp 3, Resp Dept, Beijing 100871, Peoples R China
2.Lakehead Univ, Off VP Res, Dept Biol, Thunder Bay, ON P7B 5E1, Canada
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Chen, Yahong,Wang, Rui. The message in the air: Hydrogen sulfide metabolism in chronic respiratory diseases[J]. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY,2012,184(2):130-138.
APA Chen, Yahong,&Wang, Rui.(2012).The message in the air: Hydrogen sulfide metabolism in chronic respiratory diseases.RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY,184(2),130-138.
MLA Chen, Yahong,et al."The message in the air: Hydrogen sulfide metabolism in chronic respiratory diseases".RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 184.2(2012):130-138.
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