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学科主题: 临床医学
题名:
MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma
作者: Su, Zhengming1,2,3; Ni, Liangchao2,3; Yu, Wenshui1,2; Yu, Zuhu2,4; Chen, Duqun2,4; Zhang, Enpu2; Li, Yifan2,4; Wang, Yadong5; Li, Xianxin2,3; Yang, Shangqi2,3; Gui, Yaoting2,3; Lai, Yongqing1,2,3; Ye, Jiongxian1,2,3
关键词: renal cell carcinoma ; microRNA ; miR-451a
刊名: MOLECULAR MEDICINE REPORTS
发表日期: 2015-03-01
DOI: 10.3892/mmr.2014.2957
卷: 11, 期:3, 页:2248-2254
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Research & Experimental Medicine
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; DOWN-REGULATION ; GLIOMA-CELLS ; LUNG-CANCER ; IDENTIFICATION ; EXPRESSION ; PROGNOSIS ; SURVIVAL ; INVASION
英文摘要:

MicroRNAs (miRNAs) are an important class of small, non-coding RNA molecules that regulate gene expression at the transcriptional or post-transcriptional level. They are involved in apoptosis, proliferation and migration and are known to have an important role in many types of cancer. Aberrant expression of miRNA-451a (miR-451a) has previously been reported in tumors, however its role in renal cell carcinoma (RCC) is currently unknown. The aim of the present study was to investigate the role of miR-451a in RCC. The expression of miR-451a was analyzed in 50 paired RCC and normal tissues by quantitative polymerase chain reaction. Furthermore, the effects of miR-451a on cell migration, proliferation and apoptosis were evaluated, using migration scratch, MTT and flow cytometric assays. The present study demonstrated that miR-451a was upregulated in RCC, as compared with paired normal tissues (P<0.05). Downregulation of miR-451a using a synthesized inhibitor, significantly suppressed cell migration and proliferation, and induced apoptosis of renal cancer cells in vitro, as compared with a negative control (P<0.05). In the present study, it was determined that miR-451a may have an important role as a tumor enhancer in RCC. These results imply that miR-451a may be a promising therapeutic target for the treatment of RCC.

语种: 英语
所属项目编号: 81101922 ; A2012584 ; A2013606 ; JCYJ20130402114702124
项目资助者: National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen
WOS记录号: WOS:000350917700100
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52462
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Shantou Univ, Coll Med, Dept Urol, Shantou 515041, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Inst Urol,Shenzhen PKU HKUST Med Ctr, Shenzhen 518036, Guangdong, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei 230032, Anhui, Peoples R China
5.Zunyi Med Coll, Affiliated Hosp 1, Dept Urol, Zhuhai 519100, Guangdong, Peoples R China

Recommended Citation:
Su, Zhengming,Ni, Liangchao,Yu, Wenshui,et al. MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma[J]. MOLECULAR MEDICINE REPORTS,2015,11(3):2248-2254.
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