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学科主题临床医学
MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma
Su, Zhengming1,2,3; Ni, Liangchao2,3; Yu, Wenshui1,2; Yu, Zuhu2,4; Chen, Duqun2,4; Zhang, Enpu2; Li, Yifan2,4; Wang, Yadong5; Li, Xianxin2,3; Yang, Shangqi2,3; Gui, Yaoting2,3; Lai, Yongqing1,2,3; Ye, Jiongxian1,2,3
关键词Renal Cell Carcinoma Microrna Mir-451a
刊名MOLECULAR MEDICINE REPORTS
2015-03-01
DOI10.3892/mmr.2014.2957
11期:3页:2248-2254
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; DOWN-REGULATION ; GLIOMA-CELLS ; LUNG-CANCER ; IDENTIFICATION ; EXPRESSION ; PROGNOSIS ; SURVIVAL ; INVASION
英文摘要

MicroRNAs (miRNAs) are an important class of small, non-coding RNA molecules that regulate gene expression at the transcriptional or post-transcriptional level. They are involved in apoptosis, proliferation and migration and are known to have an important role in many types of cancer. Aberrant expression of miRNA-451a (miR-451a) has previously been reported in tumors, however its role in renal cell carcinoma (RCC) is currently unknown. The aim of the present study was to investigate the role of miR-451a in RCC. The expression of miR-451a was analyzed in 50 paired RCC and normal tissues by quantitative polymerase chain reaction. Furthermore, the effects of miR-451a on cell migration, proliferation and apoptosis were evaluated, using migration scratch, MTT and flow cytometric assays. The present study demonstrated that miR-451a was upregulated in RCC, as compared with paired normal tissues (P<0.05). Downregulation of miR-451a using a synthesized inhibitor, significantly suppressed cell migration and proliferation, and induced apoptosis of renal cancer cells in vitro, as compared with a negative control (P<0.05). In the present study, it was determined that miR-451a may have an important role as a tumor enhancer in RCC. These results imply that miR-451a may be a promising therapeutic target for the treatment of RCC.

语种英语
WOS记录号WOS:000350917700100
项目编号81101922 ; A2012584 ; A2013606 ; JCYJ20130402114702124
资助机构National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52462
专题北京大学深圳医院_泌尿外科
北京大学第一临床医学院_泌尿外科
作者单位1.Shantou Univ, Coll Med, Dept Urol, Shantou 515041, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Inst Urol,Shenzhen PKU HKUST Med Ctr, Shenzhen 518036, Guangdong, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei 230032, Anhui, Peoples R China
5.Zunyi Med Coll, Affiliated Hosp 1, Dept Urol, Zhuhai 519100, Guangdong, Peoples R China
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Su, Zhengming,Ni, Liangchao,Yu, Wenshui,et al. MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma[J]. MOLECULAR MEDICINE REPORTS,2015,11(3):2248-2254.
APA Su, Zhengming.,Ni, Liangchao.,Yu, Wenshui.,Yu, Zuhu.,Chen, Duqun.,...&Ye, Jiongxian.(2015).MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma.MOLECULAR MEDICINE REPORTS,11(3),2248-2254.
MLA Su, Zhengming,et al."MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma".MOLECULAR MEDICINE REPORTS 11.3(2015):2248-2254.
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