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学科主题: 基础医学
题名:
Potent antitumor activities of recombinant human PDCD5 protein in combination with chemotherapy drugs in K562 cells
作者: Shi, Lin2; Song, Quansheng1,3; Zhang, Yingmei1,3; Lou, Yaxin4; Wang, Yanfang2; Tian, Linjie1,3; Zheng, Yi1,3; Ma, Dalong1,3; Ke, Xiaoyan2; Wang, Ying1,3
关键词: rhPDCD5 protein ; Chemotherapy ; Antitumor ; K562 ; In vivo
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2010-05-28
DOI: 10.1016/j.bbrc.2010.04.068
卷: 396, 期:2, 页:224-230
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CHRONIC MYELOID-LEUKEMIA ; GENE-EXPRESSION PROFILES ; IN-VIVO ; TUMOR-CELLS ; APOPTOSIS ; OVEREXPRESSION ; CARCINOMA ; CANCER ; DEATH ; VITRO
英文摘要:

Conventional chemotherapy is still frequently used. Programmed cell death 5 (PDCD5) enhances apoptosis of various tumor cells triggered by certain stimuli and is lowly expressed in leukemic cells from chronic myelogenous leukemia patients. Here, we describe for the first time that recombinant human PDCD5 protein (rhPDCD5) in combination with chemotherapy drugs has potent antitumor effects on chronic myelogenous leukemia K562 cells in vitro and in vivo. The antitumor efficacy of rhPDCD5 protein with chemotherapy drugs, idarubicin (IDR) or cytarabine (Ara-C), was examined in K562 cells in vitro and K562 xenograft tumor models in vivo, rhPDCD5 protein markedly increased the apoptosis rates and decreased the colony-forming capability of K562 cells after the combined treatment with IDR or Ara-C. rhPDCD5 protein by intraperitoneal administration dramatically improved the antitumor effects of IDR treatment in the K562 xenograft model. The tumor sizes and cell proliferation were significantly decreased; and TUNEL positive cells were significantly increased in the combined group with rhPDCD5 protein and IDR treatment compared with single IDR treatment groups. rhPDCD5 protein, in combination with IDR, has potent antitumor effects on chronic myelogenous leukemia K562 cells and may be a novel and promising agent for the treatment of chronic myelogenous leukemia. (C) 2010 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2006AA02A305 ; 2009ZX09503-004 ; 30872292 ; 90813025 ; 985-2-032-24
项目资助者: National High Technology Research and Development Program of China ; National Key New Drug Creation Program of China ; National Natural Science Foundation of China ; Special fund for promotion of education P.R.C.
WOS记录号: WOS:000278658000009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52464
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Peking Univ, Dept Hematol, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Med Immunol, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Peking Univ Med & Hlth Anal Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Shi, Lin,Song, Quansheng,Zhang, Yingmei,et al. Potent antitumor activities of recombinant human PDCD5 protein in combination with chemotherapy drugs in K562 cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,396(2):224-230.
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