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A new method of heparinizing PLLA film by surface entrapment
Meng, B1; Wang, XH1; Cui, FZ1; Dong, HY1; Yu, F1
关键词Heparin Biocompatibility Plla Blood Compatibility Biomaterials
刊名JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
2004-03-01
DOI10.1177/0883911504042644
19期:2页:131-143
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Materials Science, Biomaterials ; Polymer Science
研究领域[WOS]Biotechnology & Applied Microbiology ; Materials Science ; Polymer Science
关键词[WOS]POLY(LACTIC ACID) ; LOCAL-DELIVERY ; FOLLOW-UP ; STENT ; POLY(L-LACTIDE) ; BIODEGRADATION ; BIOMATERIAL ; POLYLACTIDE ; POLYMERS ; MODEL
英文摘要

A new method of surface heparinizing biodegradable polymers was designed. A heparin-modified poly(L-lactic acid) (PLLA) system was developed by physically entrapping the heparin on the PLLA surface. The surface characterization and biological performance of these materials were carried out by SEM, attenuated-total-reflection spectroscopy, contact angle measurements, and platelet adhesion evaluations. The modification strategy was performed by reversible swelling of the PLLA surface following exposure to a solvent-nonsolvent mixture. This process resulted in the localized physical entrapment of the diffused heparin. X-ray photoelectron spectroscopy was used to confirm that control over the heparin surface density can be achieved by using set polymer treatment times. Platelet adhesion tests showed significant improvement in blood compatibility by the PLLA surfaces after modification.

语种英语
WOS记录号WOS:000221643200005
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52466
专题实验动物科学部
作者单位1.Tsinghua Univ, Dept Mat Sci & Engn, Beijing 100084, Peoples R China
2.Dalian Univ Technol, Inst Biomed Engn, Dalian, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Meng, B,Wang, XH,Cui, FZ,et al. A new method of heparinizing PLLA film by surface entrapment[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2004,19(2):131-143.
APA Meng, B,Wang, XH,Cui, FZ,Dong, HY,&Yu, F.(2004).A new method of heparinizing PLLA film by surface entrapment.JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,19(2),131-143.
MLA Meng, B,et al."A new method of heparinizing PLLA film by surface entrapment".JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 19.2(2004):131-143.
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