北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 实验动物科学部  > 期刊论文
学科主题: 实验动物
题名:
A new method of heparinizing PLLA film by surface entrapment
作者: Meng, B1; Wang, XH1; Cui, FZ1; Dong, HY1; Yu, F1
关键词: heparin ; biocompatibility ; PLLA ; blood compatibility ; biomaterials
刊名: JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
发表日期: 2004-03-01
DOI: 10.1177/0883911504042644
卷: 19, 期:2, 页:131-143
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Materials Science, Biomaterials ; Polymer Science
研究领域[WOS]: Biotechnology & Applied Microbiology ; Materials Science ; Polymer Science
关键词[WOS]: POLY(LACTIC ACID) ; LOCAL-DELIVERY ; FOLLOW-UP ; STENT ; POLY(L-LACTIDE) ; BIODEGRADATION ; BIOMATERIAL ; POLYLACTIDE ; POLYMERS ; MODEL
英文摘要:

A new method of surface heparinizing biodegradable polymers was designed. A heparin-modified poly(L-lactic acid) (PLLA) system was developed by physically entrapping the heparin on the PLLA surface. The surface characterization and biological performance of these materials were carried out by SEM, attenuated-total-reflection spectroscopy, contact angle measurements, and platelet adhesion evaluations. The modification strategy was performed by reversible swelling of the PLLA surface following exposure to a solvent-nonsolvent mixture. This process resulted in the localized physical entrapment of the diffused heparin. X-ray photoelectron spectroscopy was used to confirm that control over the heparin surface density can be achieved by using set polymer treatment times. Platelet adhesion tests showed significant improvement in blood compatibility by the PLLA surfaces after modification.

语种: 英语
WOS记录号: WOS:000221643200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52466
Appears in Collections:实验动物科学部_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Tsinghua Univ, Dept Mat Sci & Engn, Beijing 100084, Peoples R China
2.Dalian Univ Technol, Inst Biomed Engn, Dalian, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100871, Peoples R China

Recommended Citation:
Meng, B,Wang, XH,Cui, FZ,et al. A new method of heparinizing PLLA film by surface entrapment[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2004,19(2):131-143.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Meng, B]'s Articles
[Wang, XH]'s Articles
[Cui, FZ]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Meng, B]‘s Articles
[Wang, XH]‘s Articles
[Cui, FZ]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace