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学科主题: 临床医学
题名:
Interactive atrial neural network: Determining the connections between ganglionated plexi
作者: Hou, Yinglong1; Scherlag, Benjamin J.1; Lin, Jiaxiong1; Zhou, Jing1; Song, Jianguo1; Zhang, Ying1; Patterson, Eugene1; Lazzara, Ralph1; Jackman, Warren M.1; Po, Sunny S.1
关键词: autonomic nervous system ; ganglionated plexi ; sinus rate ; atrioventricular conduction ; atrial fibrillation ; fat pad
刊名: HEART RHYTHM
发表日期: 2007
DOI: 10.1016/j.hrthm.2006.09.020
卷: 4, 期:1, 页:56-63
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: CARDIAC NERVOUS-SYSTEM ; ATRIOVENTRICULAR NODES ; PARASYMPATHETIC INNERVATION ; ELECTRICAL-STIMULATION ; MICROSCOPIC ANATOMY ; VAGAL INNERVATION ; SINOATRIAL ; FIBRILLATION ; ABLATION ; CATHETER
英文摘要:

BACKGROUND The electrophysiologic functions of the intrinsic cardiac autonomic nervous system (ANS) are not well understood. OBJECTIVES The purpose of this study was to investigate the functional interactions between ganglionated plexi within the intrinsic cardiac ANS.

METHODS The hearts of 21 dogs were exposed via right and/or left thoracotomy to expose the (1) anterior right ganglionated plexi near the caudal end of the sinoatrial node, (2) inferior right ganglionated plexi at the junction of inferior vena cava and atria, and (3) superior left ganglionated plexi near the junction of left superior pulmonary vein and left pulmonary artery. Ganglionated plexi were stimulated at 0.6 to 8.0 V (square waves, 20 Hz, 0.1-ms duration). Sinus rate, AH interval during atrial pacing, and ventricular rate during atrial fibrillation were compared before and after ganglionated plexi stimulation and after their ablation.

RESULTS Anterior right ganglionated plexi stimulation induced significant AH prolongation and slowing of ventricular rate and sinus rate. When inferior right ganglionated plexi was ablated, slowing of sinus rate by anterior right ganglionated plexi stimulation was unaltered, but inhibition of AV conduction was eliminated. Superior left ganglionated plexi stimulation induced similar effects on sinus and AV nodal function, and sinus rate slowing was markedly attenuated by anterior right ganglionated plexi ablation. Ablation of both anterior right ganglionated plexi and inferior right ganglionated plexi eliminated AV conduction inhibition but not sinus rate slowing by superior left ganglionated plexi stimulation.

CONCLUSION This study provides functional evidence for the interconnections between ganglionated plexi to modulate sinus and AV nodal function, supporting clinical evidence that interconnections within the intrinsic cardiac ANS are critical elements in identifying the targets for atria[ fibrillation ablation.

语种: 英语
WOS记录号: WOS:000243438300012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52470
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Univ Oklahoma, Hlth Sci Ctr, Cardiac Arrhythmia Res Inst, Oklahoma City, OK 73104 USA
2.Shandong Univ, Dept Cardiol, Shandong Prov Qianfoshan Hosp, Clin Med Coll, Shandong, Peoples R China
3.Fudan Univ, Shanghai Med Sch, Dept Cardiol, Shanghai Zhongshan Hosp, Shanghai 200433, Peoples R China
4.Peking Univ, Dept Cardiol, First Hosp, Beijing 100871, Peoples R China
5.Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Oklahoma City, OK USA

Recommended Citation:
Hou, Yinglong,Scherlag, Benjamin J.,Lin, Jiaxiong,et al. Interactive atrial neural network: Determining the connections between ganglionated plexi[J]. HEART RHYTHM,2007,4(1):56-63.
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