|Epidemiology of Functional Diarrhea and Comparison with Diarrhea-Predominant Irritable Bowel Syndrome: A Population-Based Survey in China|
|Zhao, Yan-Fang1; Guo, Xiao-Jing1; Zhang, Zhan-Sai2; Ma, Xiu-Qiang1; Wang, Rui1; Yan, Xiao-Yan3; He, Jia1|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||ROME-II CRITERIA ; GASTROINTESTINAL DISORDERS ; UNITED-STATES ; COLONIC TRANSIT ; ABDOMINAL-PAIN ; PREVALENCE ; VALIDATION ; COMMUNITY ; SYMPTOMS ; GENDER|
Background: The epidemiology of functional diarrhea and its impacts on Chinese remain unclear, and there are no data on the comparative epidemiology of functional diarrhea and diarrhea-predominant irritable bowel syndrome (IBS-D). This study was to explore the epidemiology of functional diarrhea and its impacts, and to identify its distinction from IBS-D.
Methods and Findings: A cross-sectional survey was conducted in 16078 respondents, who were interviewed under a randomized stratified multi-stage sampling design in five cities of China. All respondents completed the modified Rome II questionnaire, and the 36-item Short Form health survey (SF-36) was used for assessing health-related quality of life in 20% of the sample. Overall, 248 respondents (1.54%) had functional diarrhea and 277 (1.72%) had IBS-D. Functional diarrhea was positively associated with increasing age and body mass index (trend test P<0.05). The three most common symptoms for at least 3 weeks in the past months were loose, mushy or watery stools (n = 203, 81.85%), more than three bowel movements a day (n = 100, 40.32%) and having to rush to the toilet to have a bowel movement (n = 72, 29.03%). Meaningful impairment was observed in 5 of the 8 SF-36 domains in respondents with functional diarrhea. The demographics are mostly similar between the respondents with functional diarrhea and IBS-D; however, respondents with IBS-D had more frequent symptoms of diarrhea and even lower scores in SF-36 domains than those with functional diarrhea.
Conclusions: The prevalence of functional diarrhea in China is substantially lower than that in Western countries and relatively higher than that in other Asian countries. It impaired health-related quality of life, and respondents with IBS-D have even worse quality of life. Further population-based studies are needed to investigate the epidemiology of functional diarrhea and the differences between functional diarrhea and IBS-D.
|资助机构||key discipline construction of evidence-based public health in Shanghai|
|作者单位||1.Second Mil Med Univ, Dept Hlth Stat, Shanghai, Peoples R China|
2.Shanghai Inst Occupat Safety & Hlth, Testing Ctr Occupat Hlth, Shanghai, Peoples R China
3.Peking Univ, Clin Res Inst, Beijing 100871, Peoples R China
|Zhao, Yan-Fang,Guo, Xiao-Jing,Zhang, Zhan-Sai,et al. Epidemiology of Functional Diarrhea and Comparison with Diarrhea-Predominant Irritable Bowel Syndrome: A Population-Based Survey in China[J]. PLOS ONE,2012,7(8).|
|APA||Zhao, Yan-Fang.,Guo, Xiao-Jing.,Zhang, Zhan-Sai.,Ma, Xiu-Qiang.,Wang, Rui.,...&He, Jia.(2012).Epidemiology of Functional Diarrhea and Comparison with Diarrhea-Predominant Irritable Bowel Syndrome: A Population-Based Survey in China.PLOS ONE,7(8).|
|MLA||Zhao, Yan-Fang,et al."Epidemiology of Functional Diarrhea and Comparison with Diarrhea-Predominant Irritable Bowel Syndrome: A Population-Based Survey in China".PLOS ONE 7.8(2012).|