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学科主题: 临床医学
题名:
Lymphatic vascular invasion is an independent correlated factor for lymph node metastasis and the prognosis of resectable T2 gastric cancer patients
作者: Bu, Zhaode1; Zheng, Zhixue1; Li, Ziyu1; Zhang, Lianhai1; Wu, Aiwen1; Wu, Xiaojiang1; Sun, Yu2; Ji, Jiafu1,3
关键词: Gastric cancer ; Lymph node metastasis ; Prognosis ; Lymphatic vascular invasion
刊名: TUMOR BIOLOGY
发表日期: 2013-04-01
DOI: 10.1007/s13277-012-0637-3
卷: 34, 期:2, 页:1005-1012
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ADENOCARCINOMA ; CHEMOTHERAPY
英文摘要:

The objective of this study was to investigate the independent correlated factors for lymph node metastasis (LNM) and prognosis in T2 gastric cancer patients. A total of 135 pathologically confirmed T2 gastric cancer patients who received a gastrectomy at the Beijing University Cancer Hospital from Dec 1999 to Dec 2006 were studied retrospectively. The potential correlated factors for LNM and patients′ prognosis were analyzed, including gender, age, tumor location and size, depth of invasion, lymphatic vascular invasion (LVI), differentiation grade, histological type, Borrmann type, LNM, distant metastasis, TNM stage, and whether the patient was treated with a radical gastrectomy. LNM occurred in 69 patients, which represents a rate of LNM of 51.1 %. Multivariate logistic regression analysis showed that LVI and TNM stage were independent risk factors for LNM (p values were 0.002 and 0.029, respectively). The median follow-up time was 60.3 months. Multivariable survival analysis revealed that age (< 60 vs. a parts per thousand yen60), TNM stage and LVI were independent prognostic factors for gastric cancer patients (p values were < 0.001, 0.047, and 0.001, respectively). In conclusion, LVI was an independent factor for LNM and the prognosis of resectable T2 gastric cancer patients.

语种: 英语
WOS记录号: WOS:000316364500047
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52475
Appears in Collections:北京大学临床肿瘤学院_肿瘤外科_期刊论文

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作者单位: 1.Peking Univ, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Surg,Sch Oncol,Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Pathol,Sch Oncol,Minist Educ, Beijing 100871, Peoples R China
3.Peking Univ, Dept Surg, Canc Hosp, Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China

Recommended Citation:
Bu, Zhaode,Zheng, Zhixue,Li, Ziyu,et al. Lymphatic vascular invasion is an independent correlated factor for lymph node metastasis and the prognosis of resectable T2 gastric cancer patients[J]. TUMOR BIOLOGY,2013,34(2):1005-1012.
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