IR@PKUHSC  > 北京大学药学院
学科主题药学
Total Synthesis of (+)-Lysergic Acid
Liu, Qiang1; Jia, Yanxing1
刊名ORGANIC LETTERS
2011-09-16
DOI10.1021/ol2018467
13期:18页:4810-4813
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; NCET ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; NCET
研究领域[WOS]Chemistry
关键词[WOS]RING-CLOSING METATHESIS ; EFFICIENT TOTAL-SYNTHESIS ; SUZUKI-MIYAURA REACTION ; FORMAL TOTAL-SYNTHESIS ; LYSERGIC-ACID ; (+/-)-LYSERGIC ACID ; ERGOT ALKALOIDS ; (&amp ; /-)-LYSERGIC ACID ; DIRECT ANNULATION ; CHLOROPEPTIN-I
英文摘要

A stereocontrolled total synthesis of (+)-lysergic acid (1) is achieved using three metal-catalyzed methodologies for the construction of three key rings. Highlights of the synthesis include Pd-catalyzed indole synthesis to form the Bring, a RCM reaction to form the D ring, and an intramolecular Heck reaction to form the C ring.

语种英语
所属项目编号20972007 ; 20802005 ; 2010CB833200
资助者National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; NCET ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; NCET
WOS记录号WOS:000294703900015
Citation statistics
Cited Times:47[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52476
Collection北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organ Chem, Nanchang 330013, Peoples R China
Recommended Citation
GB/T 7714
Liu, Qiang,Jia, Yanxing. Total Synthesis of (+)-Lysergic Acid[J]. ORGANIC LETTERS,2011,13(18):4810-4813.
APA Liu, Qiang,&Jia, Yanxing.(2011).Total Synthesis of (+)-Lysergic Acid.ORGANIC LETTERS,13(18),4810-4813.
MLA Liu, Qiang,et al."Total Synthesis of (+)-Lysergic Acid".ORGANIC LETTERS 13.18(2011):4810-4813.
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