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学科主题: 临床医学
题名:
Negative association of donor age with CD34(+) cell dose in mixture allografts of G-CSF-primed bone marrow and G-CSF-mobilized peripheral blood harvests
作者: Li Yan; Chang Yingjun; Xu Lanping; Zhang Xiaohui; Huang Xiaojun
关键词: healthy donors ; hematopoietic stem cell mobilization ; granulocyte colony-stimulating factor ; CD34(+) cell dose ; age
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-10-20
DOI: 10.3760/cma.j.issn.0366-6999.20141161
卷: 127, 期:20, 页:3597-3601
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: HEMATOLOGIC MALIGNANCIES ; PROCEDURAL SETTINGS ; RISK-FACTORS ; TRANSPLANTATION ; IMPACT ; COLLECTION ; YIELD ; ENGRAFTMENT ; POPULATION ; PREDICTORS
英文摘要:

Background The effects of donor characteristics on CD34(+) cell dose remain controversial. Recently, we developed a novel haploidentical transplant protocol, in which mixture allografts of granulocyte colony-stimulating factor (G-CSF)-primed bone marrow (G-BM) and G-CSF-mobilized peripheral blood (G-PB) were used. The aim of this study was to investigate the effects of donor characteristics on CD34(+) cell dose in mixture allografts of G-BM and G-PB.

Methods A total of 162 healthy adult donors, who underwent bone marrow harvest and peripheral blood collection between January 2009 and November 2010 in Peking University People′s Hospital, were prospectively investigated. G-CSF was administered subcutaneously at a dose of 5 mu g/kg once a day for 5-6 consecutive days. Bone marrow and peripheral blood stem cells were harvested on the fourth day and fifth day, respectively. A final total CD34(+) cell dose less than 2x10(6) cells/kg recipient body weight was considered a poor mobilization.

Results Of the 162 donors, 31(19.1%) did not attain this threshold. The obtained median CD34(+) cell doses in bone marrow, peripheral blood, and mixture allografts were 0.83x10(6)/kg, 2.40x10(6)/kg, and 3.47x10(6)/kg, respectively. Multiple regression analysis showed that donor age had a significant negative effect on CD34(+) cell dose in either G-BM, or G-PB, or mixture allografts of G-BM and G-PB. And a. 1-year increase in age was associated with a 5.6% decrease in the odds of achieving mobilization cutoff. No significant correlation was found for donor gender, body mass index (BMI), and weight.

Conclusion Donor age is the Only factor among the four parameters, including age, gender, weight, and BMI, that influence CD34(+) cell dose-in Mixture allografts of G-BM and G-PB, and younger donors should be chosen to obtain sufficient CD34(+) cell for transplantation.

语种: 英语
所属项目编号: 2011006
项目资助者: Chang Jiang Scholars Program
WOS记录号: WOS:000344724100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52479
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Li Yan,Chang Yingjun,Xu Lanping,et al. Negative association of donor age with CD34(+) cell dose in mixture allografts of G-CSF-primed bone marrow and G-CSF-mobilized peripheral blood harvests[J]. CHINESE MEDICAL JOURNAL,2014,127(20):3597-3601.
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