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学科主题: 基础医学
题名:
Effects of exogenous hyaluronan on midline crossing and axon divergence in the optic chiasm of mouse embryos
作者: Lin, Ling1; Wang, Jun1; Chan, Chung-Kit1; Chan, Sun-On1
关键词: axon guidance ; CD44 ; extracellular matrix ; hyaluronic acid ; retina
刊名: EUROPEAN JOURNAL OF NEUROSCIENCE
发表日期: 2007-07-01
DOI: 10.1111/j.1460-9568.2007.05642.x
卷: 26, 期:1, 页:1-11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CHONDROITIN SULFATE PROTEOGLYCAN ; TUMOR-CELL MIGRATION ; RETINOFUGAL PATHWAY ; EXTRACELLULAR-MATRIX ; ADHESION MOLECULES ; UNCROSSED AXONS ; RETINAL AXONS ; CD44 ; EXPRESSION ; NEURONS
英文摘要:

Perturbation of the transmembrane glycoprotein, CD44, has been shown to cause multiple errors in axon routing in the mouse optic chiasm. In a recent report we have shown that the major CD44 ligand, hyaluronan (HA), is colocalized with CD44 at the midline of the chiasm, suggesting a possible contribution to the control of axon routing in the chiasm. We examined this issue by investigating the effects of exogenous HA on routing of axons in the chiasm in slice preparations of the optic pathway. In preparations of the E13 optic pathway, administration of exogenous HA produced a dose-dependent failure in midline crossing of the first generated optic axons. In E15 slices, when the adult pattern of axon divergence develops in the chiasm, anterograde filling of the optic axons showed an obvious reduction in the uncrossed pathway after HA treatment. This reduction was confirmed by retrograde filling of the ganglion cells in E15 slices, and later in E16 pathways where the uncrossed projection is better developed. Furthermore, we have demonstrated in explant cultures of the retina that HA, when presented in soluble or substrate-bound form, does not affect outgrowth and extension of retinal neurites. These findings together indicate the crucial functions of this matrix molecule in regulating midline crossing and axon divergence, probably through interactions with guidance molecules including CD44, at the midline of the chiasm.

语种: 英语
WOS记录号: WOS:000247754800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52480
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Anat & Embryol, Beijing 100871, Peoples R China

Recommended Citation:
Lin, Ling,Wang, Jun,Chan, Chung-Kit,et al. Effects of exogenous hyaluronan on midline crossing and axon divergence in the optic chiasm of mouse embryos[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2007,26(1):1-11.
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