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学科主题临床医学
Serial Changes of Circulating Platelet Activation Markers After Carotid Artery Stenting
Liu, Fang1,2; Li, Jin2; Wang, Da-Ming3; Liu, Jia-Chun3; Huang, Yi-Ning1
关键词Carotid Arteries Stents Platelet Activation
刊名ANGIOLOGY
2009-08-01
DOI10.1177/0003319708321103
60期:4页:427-430
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]SURFACE P-SELECTIN ; CORONARY INTERVENTION ; ENDARTERECTOMY ; IMPLANTATION ; AGGREGATION ; EXPRESSION ; THERAPY
英文摘要

We investigated serial changes of circulation platelet activation markers in 40 patients undergoing carotid artery stenting under the protection of dual antiplatelet therapy and filter devices. Monocyte-platelet aggregates and PAC-1 (a marker specific for activated glycoprotein IIb/IIIa) analyzed by flow cytometry were determined in patients with symptomatic stenosis undergoing elective carotid artery stenting. Blood samples were obtained immediately before stent implantation and 0.5 hours, 18 hours, and 6 days after the procedure, respectively. All patients were already on dual antiplatelet therapy of aspirin and clopidogrel before carotid artery stenting, and all were stented with embolic protection devices. Both circulation monocyte-platelet aggregates and PAC-1 did not change significantly at the various time points after the procedure. Serial changes of monocyte-platelet aggregates and PAC-1 analyzed by flow cytometry fail to indicate the occurrence of platelet activation after carotid artery stenting under the treatment with dual antiplatelet therapy before carotid artery stenting and the application of embolic protection devices during the procedure.

语种英语
WOS记录号WOS:000269602000005
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52486
专题北京大学第一临床医学院_神经内科
作者单位1.Minist Hlth, Beijing Hosp, Dept Neurol, Beijing, Peoples R China
2.Minist Hlth, Beijing Hosp, Dept Neurosurg, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Liu, Fang,Li, Jin,Wang, Da-Ming,et al. Serial Changes of Circulating Platelet Activation Markers After Carotid Artery Stenting[J]. ANGIOLOGY,2009,60(4):427-430.
APA Liu, Fang,Li, Jin,Wang, Da-Ming,Liu, Jia-Chun,&Huang, Yi-Ning.(2009).Serial Changes of Circulating Platelet Activation Markers After Carotid Artery Stenting.ANGIOLOGY,60(4),427-430.
MLA Liu, Fang,et al."Serial Changes of Circulating Platelet Activation Markers After Carotid Artery Stenting".ANGIOLOGY 60.4(2009):427-430.
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