IR@PKUHSC  > 北京大学第二临床医学院  > 重症医学科
学科主题临床医学
Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study
Wen Ying1; Jiang Li1; Xu Yuan2; Qian Chuan-yun3; Li Shu-sheng4; Qin Tie-he5; Chen Er-zhen6; Lin Jian-dong7; Ai Yu-hang8; Wu Da-wei9; Wang Yu-shan10; Sun Ren-hua11; Hu Zhen-jie12; Cao Xiang-yuan13; Zhou Fa-chun14; He Zhen-yang15; Zhou Li-hua16; An You-zhong17; Kang Yan18; Ma Xiao-chun19; Yu Xiang-you20; Zhao Ming-yan21; Xi Xiu-ming1; Du Bin22; CCCCTG1
关键词Acute Kidney Injury Intensive Care Units Mortality Prevalence Risk Factors
刊名CHINESE MEDICAL JOURNAL
2013-12-05
DOI10.3760/cma.j.issn.0366-6999.20132065
126期:23页:4409-4416
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者Beijing Municipal Science &amp ; Technology Commission (BSTC) ; Beijing Municipal Science &amp ; Technology Commission (BSTC)
研究领域[WOS]General & Internal Medicine
关键词[WOS]CRITICALLY-ILL PATIENTS ; ACUTE-RENAL-FAILURE ; RIFLE CRITERIA ; URINE OUTPUT ; PROSPECTIVE MULTICENTER ; CONSENSUS CONFERENCE ; ORGAN FAILURE ; MORTALITY ; SEPSIS ; CLASSIFICATION
英文摘要

Background Acute kidney injury (AKI) has been recognized as a major healthcare problem affecting millions of patients worldwide. However, epidemiologic data concerning AKI in China are still lacking. The objectives of this study were to characterize AKI defined by RIFLE criteria, assess the association with hospital mortality, and evaluate the impact of AKI in the context of other risk factors.

Methods This prospective multicenter observational study enrolled 3,063 consecutive patients from 1 July 2009 to 31 August 2009 in 22 ICUs across mainland China. We excluded patients who were admitted for less than 24 hours (n=1623), younger than 18 years (n=127), receiving chronic hemodialysis (n=29), receiving renal transplantation (n=1) and unknown reasons (n=28). There were 1255 patients in the final analysis. AKI was diagnosed and classified according to RIFLE criteria.

Results There were 396 patients (31.6%) who had AKI, with RIFLE maximum class R, I, and F in 126 (10.0%), 91(7.3%), and 179 (14.3%) patients, respectively. Renal function deteriorated in 206 patients (16.4%). In comparison with non AKI patients, patients in the risk class on ICU admission were more likely to progress to the injury class (odds ratio (OR) 3.564, 95% confidence interval (Cl) 1.706-7.443, P = 0.001], while patients in the risk class (OR 5.215, 95% CI 2.798-9.719, P <0.001) and injury class (OR 13.316, 95% CI 7.507-23.622, P <0.001) had a significantly higher probability of deteriorating into failure class. The adjusted hazard ratios for 90-day mortality were 1.884 for the risk group, 3.401 for the injury group, and 5.306 for the failure group.

Conclusions The prevalence of AKI was high among critically ill patients in Chinese ICUs. In comparison with non-AKI patients, patients with RIFLE class R or class I on ICU admission were more susceptibility to progression to class I or class F. The RIFLE criteria were robust and correlated well with clinical deterioration and mortality.

语种英语
所属项目编号101100050010058
资助者Beijing Municipal Science &amp ; Technology Commission (BSTC) ; Beijing Municipal Science &amp ; Technology Commission (BSTC)
WOS记录号WOS:000329084100002
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52489
专题北京大学第二临床医学院_重症医学科
作者单位1.Capital Med Univ, Dept Crit Care Med, Fuxing Hosp, Beijing 100038, Peoples R China
2.Capital Med Univ, Beijing Tongren Hosp, Dept Crit Care Med, Beijing 100730, Peoples R China
3.Kunming Med Coll, Affiliated Hosp 1, Dept Emergency Med, Kunming 650032, Yunnan, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Crit Care Med, Wuhan 430030, Hubei, Peoples R China
5.Guangdong Gen Hosp, Dept Crit Care Med, Guangzhou 510080, Guangdong, Peoples R China
6.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Emergency Med, Shanghai 200025, Peoples R China
7.Fujian Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Fuzhou 350005, Fujian, Peoples R China
8.Cent S Univ, Xiangya Hosp, Dept Crit Care Med, Changsha 410008, Hunan, Peoples R China
9.Shandong Univ, Qilu Hosp, Dept Crit Care Med, Jinan 250012, Shandong, Peoples R China
10.Jilin Univ, Hosp 2, Depaitinent Emergency & Crit Care Med, Changchun 130041, Jilin, Peoples R China
11.Zhejiang Prov Peoples Hosp, Dept Crit Care Med, Hangzhou 310014, Zhejiang, Peoples R China
12.Hebei Med Univ, Dept Crit Care Med, Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China
13.Affiliated Hosp Ningxia Med Univ, Dept Crit Care Med, Yinchuan 750004, Ningxia, Peoples R China
14.Chongqing Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Chongqing 400016, Peoples R China
15.Hainan Prov Peoples Hosp, Dept Crit Care Med, Haikou 570311, Hainan, Peoples R China
16.Affiliated Hosp Inner Mongolia Med Coll, Depai talent Crit Care Med, Hohhot 010050, Inner Mongolia, Peoples R China
17.Peking Univ Peoples Hosp, Dept Crit Care Med, Beijing 100044, Peoples R China
18.Sichuan Univ, West China Hosp, Dept Crit Care Med, Chengdu 610041, Sichuan, Peoples R China
19.China Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Shenyang 110001, Liaoning, Peoples R China
20.Xinjiang Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Urumqi 830054, Xinjiang, Peoples R China
21.Haerbin Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Haerbin 150001, Heilongjiang, Peoples R China
22.Beijing Union Med Coll Hosp, Med Intens Care Unit, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714
Wen Ying,Jiang Li,Xu Yuan,et al. Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study[J]. CHINESE MEDICAL JOURNAL,2013,126(23):4409-4416.
APA Wen Ying.,Jiang Li.,Xu Yuan.,Qian Chuan-yun.,Li Shu-sheng.,...&CCCCTG.(2013).Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study.CHINESE MEDICAL JOURNAL,126(23),4409-4416.
MLA Wen Ying,et al."Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study".CHINESE MEDICAL JOURNAL 126.23(2013):4409-4416.
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