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学科主题: 临床医学
题名:
Effect of Hepatocyte Growth-Promoting Factors on Myocardial Ischemia During Exercise in Patients With Severe Coronary Artery Disease
作者: Wang, Ningfu1,2; Tong, Guoxin1,2; Yang, Jianmin1,2; Zhou, Zhanlin1,2; Pan, Hao1,2; Huo, Yong3; Xu, Jian1,2; Zhang, Xingwei4; Ling, Feng1,2; Li, Peizhang1,2
关键词: Coronary artery disease ; Hepatocyte growth factor ; Myocardial ischemia ; Cardiopulmonary exercise test
刊名: INTERNATIONAL HEART JOURNAL
发表日期: 2009-05-01
卷: 50, 期:3, 页:291-299
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: COLLATERAL FORMATION ; PROGNOSTIC VALUE ; HEART-FAILURE ; FACTOR GENE ; ANGIOGENESIS ; SLOPE ; RAT
英文摘要:

Hepatocyte growth-promoting factor (pHGF) has the greatest potential as a therapeutic agent for vascular growth factor. The aim of this study was to investigate the effect of pHGF on myocardial ischemia and exercise capacity in patients with severe coronary artery disease (CAD).

Forty-nine patients were enrolled for a two week treatment period. Treadmill graded exercise tests with gas analysis were conducted before and after therapy. Serum levels of HGF were significantly elevated after therapy. The degrees of exercise-induced ST segment depression were decreased more significantly in the pHGF group. Similar differences were also found in the maximum heart rate and the maximum heart rate when the ST segment was depressed I mm while undergoing the treadmill graded exercise test. Both were increased more significantly in the pHGF group. Total exercise time, systolic blood pressure in the peak of exercise, the length of time that ST segment depression of 1 mm is needed, and total work all were increased in both groups after intervention. Furthermore, total exercise time and total work were increased more significantly in the pHGF group.

The levels of HGF increased significantly after pHGF treatment. pHGF could favorably improve exercise-induced myocardial ischemia and enhance exercise capacity in patients with severe CAD. (Int Heart J 2009; 50:291-299)

语种: 英语
WOS记录号: WOS:000267816000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52494
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Nanjing Med Univ, Peoples Hosp Hangzhou 1, Dept Cardiol, Hangzhou 310006, Zhejiang, Peoples R China
2.Nanjing Med Univ, Affiliated Hangzhou Hosp, Hangzhou 310006, Zhejiang, Peoples R China
3.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
4.Hangzhou Teachers Univ, Affiliated Hosp, Dept Cardiol, Hangzhou, Zhejiang, Peoples R China

Recommended Citation:
Wang, Ningfu,Tong, Guoxin,Yang, Jianmin,et al. Effect of Hepatocyte Growth-Promoting Factors on Myocardial Ischemia During Exercise in Patients With Severe Coronary Artery Disease[J]. INTERNATIONAL HEART JOURNAL,2009,50(3):291-299.
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