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学科主题临床医学
Effect of Hepatocyte Growth-Promoting Factors on Myocardial Ischemia During Exercise in Patients With Severe Coronary Artery Disease
Wang, Ningfu1,2; Tong, Guoxin1,2; Yang, Jianmin1,2; Zhou, Zhanlin1,2; Pan, Hao1,2; Huo, Yong3; Xu, Jian1,2; Zhang, Xingwei4; Ling, Feng1,2; Li, Peizhang1,2
关键词Coronary Artery Disease Hepatocyte Growth Factor Myocardial Ischemia Cardiopulmonary Exercise Test
刊名INTERNATIONAL HEART JOURNAL
2009-05-01
50期:3页:291-299
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]COLLATERAL FORMATION ; PROGNOSTIC VALUE ; HEART-FAILURE ; FACTOR GENE ; ANGIOGENESIS ; SLOPE ; RAT
英文摘要

Hepatocyte growth-promoting factor (pHGF) has the greatest potential as a therapeutic agent for vascular growth factor. The aim of this study was to investigate the effect of pHGF on myocardial ischemia and exercise capacity in patients with severe coronary artery disease (CAD).

Forty-nine patients were enrolled for a two week treatment period. Treadmill graded exercise tests with gas analysis were conducted before and after therapy. Serum levels of HGF were significantly elevated after therapy. The degrees of exercise-induced ST segment depression were decreased more significantly in the pHGF group. Similar differences were also found in the maximum heart rate and the maximum heart rate when the ST segment was depressed I mm while undergoing the treadmill graded exercise test. Both were increased more significantly in the pHGF group. Total exercise time, systolic blood pressure in the peak of exercise, the length of time that ST segment depression of 1 mm is needed, and total work all were increased in both groups after intervention. Furthermore, total exercise time and total work were increased more significantly in the pHGF group.

The levels of HGF increased significantly after pHGF treatment. pHGF could favorably improve exercise-induced myocardial ischemia and enhance exercise capacity in patients with severe CAD. (Int Heart J 2009; 50:291-299)

语种英语
WOS记录号WOS:000267816000003
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52494
专题北京大学第一临床医学院_心血管内科
作者单位1.Nanjing Med Univ, Peoples Hosp Hangzhou 1, Dept Cardiol, Hangzhou 310006, Zhejiang, Peoples R China
2.Nanjing Med Univ, Affiliated Hangzhou Hosp, Hangzhou 310006, Zhejiang, Peoples R China
3.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
4.Hangzhou Teachers Univ, Affiliated Hosp, Dept Cardiol, Hangzhou, Zhejiang, Peoples R China
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GB/T 7714
Wang, Ningfu,Tong, Guoxin,Yang, Jianmin,et al. Effect of Hepatocyte Growth-Promoting Factors on Myocardial Ischemia During Exercise in Patients With Severe Coronary Artery Disease[J]. INTERNATIONAL HEART JOURNAL,2009,50(3):291-299.
APA Wang, Ningfu.,Tong, Guoxin.,Yang, Jianmin.,Zhou, Zhanlin.,Pan, Hao.,...&Li, Peizhang.(2009).Effect of Hepatocyte Growth-Promoting Factors on Myocardial Ischemia During Exercise in Patients With Severe Coronary Artery Disease.INTERNATIONAL HEART JOURNAL,50(3),291-299.
MLA Wang, Ningfu,et al."Effect of Hepatocyte Growth-Promoting Factors on Myocardial Ischemia During Exercise in Patients With Severe Coronary Artery Disease".INTERNATIONAL HEART JOURNAL 50.3(2009):291-299.
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