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学科主题临床医学
Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats
Yang, Chang-Qing; Wei, Yan-Yu; Zhong, Chan-Juan; Duan, Li-Ping
刊名MEDIATORS OF INFLAMMATION
2012
DOI10.1155/2012/294070
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
资助者National Natural Science Foundation of China ; Beijing Nature Science Foundation ; National Natural Science Foundation of China ; Beijing Nature Science Foundation
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]NERVE GROWTH-FACTOR ; IRRITABLE-BOWEL-SYNDROME ; COLONIC HYPERSENSITIVITY ; IBS PATIENTS ; PAIN ; ACTIVATION ; NEURONS ; TRPV1 ; HYPEREXCITABILITY ; INVOLVEMENT
英文摘要

Mast cells (MCs) deficient rats (Ws/Ws) were used to investigate the roles of MCs in visceral hyperalgesia. Ws/Ws and wild control (+/+) rats were exposed to T. spiralis or submitted to acute cold restraint stress (ACRS). Levels of proteinase-activated receptor 2 (PAR2) and nerve growth factor (NGF) were determined by immunoblots and RT-PCR analysis, and the putative signal pathways including phosphorylated extracellular-regulated kinase (pERK1/2) and transient receptor potential vanilloid receptor 1 (TRPV1) were further identified. Visceral hyperalgesia triggered by ACRS was observed only in +/+ rats. The increased expression of PAR2 and NGF was observed only in +/+ rats induced by T. spiralis and ACRS. The activation of pERK1/2 induced by ACRS occurred only in +/+ rats. However, a significant increase of TRPV1 induced by T. spiralis and ACRS was observed only in +/+ rats. The activation of PAR2 and NGF via both TRPV1 and pERK1/2 signal pathway is dependent on MCs in ACRS-induced visceral hyperalgesia rats.

语种英语
所属项目编号30470776 ; 7082102
资助者National Natural Science Foundation of China ; Beijing Nature Science Foundation ; National Natural Science Foundation of China ; Beijing Nature Science Foundation
WOS记录号WOS:000302648800001
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52499
专题北京大学第三临床医学院_消化科
作者单位Peking Univ Third Hosp, Dept Gastroenterol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Chang-Qing,Wei, Yan-Yu,Zhong, Chan-Juan,et al. Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats[J]. MEDIATORS OF INFLAMMATION,2012.
APA Yang, Chang-Qing,Wei, Yan-Yu,Zhong, Chan-Juan,&Duan, Li-Ping.(2012).Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats.MEDIATORS OF INFLAMMATION.
MLA Yang, Chang-Qing,et al."Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats".MEDIATORS OF INFLAMMATION (2012).
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