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学科主题: 临床医学
题名:
Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats
作者: Yang, Chang-Qing; Wei, Yan-Yu; Zhong, Chan-Juan; Duan, Li-Ping
刊名: MEDIATORS OF INFLAMMATION
发表日期: 2012
DOI: 10.1155/2012/294070
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: NERVE GROWTH-FACTOR ; IRRITABLE-BOWEL-SYNDROME ; COLONIC HYPERSENSITIVITY ; IBS PATIENTS ; PAIN ; ACTIVATION ; NEURONS ; TRPV1 ; HYPEREXCITABILITY ; INVOLVEMENT
英文摘要:

Mast cells (MCs) deficient rats (Ws/Ws) were used to investigate the roles of MCs in visceral hyperalgesia. Ws/Ws and wild control (+/+) rats were exposed to T. spiralis or submitted to acute cold restraint stress (ACRS). Levels of proteinase-activated receptor 2 (PAR2) and nerve growth factor (NGF) were determined by immunoblots and RT-PCR analysis, and the putative signal pathways including phosphorylated extracellular-regulated kinase (pERK1/2) and transient receptor potential vanilloid receptor 1 (TRPV1) were further identified. Visceral hyperalgesia triggered by ACRS was observed only in +/+ rats. The increased expression of PAR2 and NGF was observed only in +/+ rats induced by T. spiralis and ACRS. The activation of pERK1/2 induced by ACRS occurred only in +/+ rats. However, a significant increase of TRPV1 induced by T. spiralis and ACRS was observed only in +/+ rats. The activation of PAR2 and NGF via both TRPV1 and pERK1/2 signal pathway is dependent on MCs in ACRS-induced visceral hyperalgesia rats.

语种: 英语
所属项目编号: 30470776 ; 7082102
项目资助者: National Natural Science Foundation of China ; Beijing Nature Science Foundation
WOS记录号: WOS:000302648800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52499
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: Peking Univ Third Hosp, Dept Gastroenterol, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Chang-Qing,Wei, Yan-Yu,Zhong, Chan-Juan,et al. Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats[J]. MEDIATORS OF INFLAMMATION,2012.
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