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学科主题: 基础医学
题名:
Regulatory activity of activated murine peripheral CD4(+)CD25(-) T cells: A possible mechanism of feedback regulation on adaptive immunity
作者: Lu, Y.; Xu, W.; Zhou, Y.; Lv, P.; Gao, X. -M.
刊名: SCANDINAVIAN JOURNAL OF IMMUNOLOGY
发表日期: 2006-11-01
DOI: 10.1111/j.1365-3083.2006.01842.x
卷: 64, 期:5, 页:500-506
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: IMMUNOLOGICAL SELF-TOLERANCE ; IN-VITRO ; INDUCTION ; CD4(+) ; BETA ; APOPTOSIS ; RESPONSES ; FOXP3 ; MICE ; STIMULATION
英文摘要:

This study was undertaken to investigate the possibility that peripheral CD4(+) CD25(-) T cells, once fully activated, transiently obtain suppressive function against other T cells. CD4(+) CD25(-) T cells, isolated from splenocytes of BALB/c mice, were stimulated with anti-CD3 MoAb in the presence of feeder cells for 72 h. The activated CD4(+) T cells (T-act) thus obtained were able to inhibit the activation and proliferation of bystander CD4(+) T cells in a non-MHC- restricted manner. T-act-mediated suppression was cell contact dependent, reversible by exogenous IL-2 as well as anti-GITR antibody. Furthermore, adoptive transfer of Tact cells significantly downregulated humoral response of BALB/c mice to s.c. immunization with ovalbumin. We argue that suppression ;mediated by activated CD4(+) CD25(-) T cells may play an important role in maintaining homeostasis of the immune system and preventing excessive T-cell responses in vivo.

语种: 英语
WOS记录号: WOS:000241112400006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52504
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Peking Univ, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Lu, Y.,Xu, W.,Zhou, Y.,et al. Regulatory activity of activated murine peripheral CD4(+)CD25(-) T cells: A possible mechanism of feedback regulation on adaptive immunity[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY,2006,64(5):500-506.
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