IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Regulatory activity of activated murine peripheral CD4(+)CD25(-) T cells: A possible mechanism of feedback regulation on adaptive immunity
Lu, Y.; Xu, W.; Zhou, Y.; Lv, P.; Gao, X. -M.
刊名SCANDINAVIAN JOURNAL OF IMMUNOLOGY
2006-11-01
DOI10.1111/j.1365-3083.2006.01842.x
64期:5页:500-506
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]IMMUNOLOGICAL SELF-TOLERANCE ; IN-VITRO ; INDUCTION ; CD4(+) ; BETA ; APOPTOSIS ; RESPONSES ; FOXP3 ; MICE ; STIMULATION
英文摘要

This study was undertaken to investigate the possibility that peripheral CD4(+) CD25(-) T cells, once fully activated, transiently obtain suppressive function against other T cells. CD4(+) CD25(-) T cells, isolated from splenocytes of BALB/c mice, were stimulated with anti-CD3 MoAb in the presence of feeder cells for 72 h. The activated CD4(+) T cells (T-act) thus obtained were able to inhibit the activation and proliferation of bystander CD4(+) T cells in a non-MHC- restricted manner. T-act-mediated suppression was cell contact dependent, reversible by exogenous IL-2 as well as anti-GITR antibody. Furthermore, adoptive transfer of Tact cells significantly downregulated humoral response of BALB/c mice to s.c. immunization with ovalbumin. We argue that suppression ;mediated by activated CD4(+) CD25(-) T cells may play an important role in maintaining homeostasis of the immune system and preventing excessive T-cell responses in vivo.

语种英语
WOS记录号WOS:000241112400006
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52504
专题北京大学基础医学院_免疫学系
作者单位Peking Univ, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Lu, Y.,Xu, W.,Zhou, Y.,et al. Regulatory activity of activated murine peripheral CD4(+)CD25(-) T cells: A possible mechanism of feedback regulation on adaptive immunity[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY,2006,64(5):500-506.
APA Lu, Y.,Xu, W.,Zhou, Y.,Lv, P.,&Gao, X. -M..(2006).Regulatory activity of activated murine peripheral CD4(+)CD25(-) T cells: A possible mechanism of feedback regulation on adaptive immunity.SCANDINAVIAN JOURNAL OF IMMUNOLOGY,64(5),500-506.
MLA Lu, Y.,et al."Regulatory activity of activated murine peripheral CD4(+)CD25(-) T cells: A possible mechanism of feedback regulation on adaptive immunity".SCANDINAVIAN JOURNAL OF IMMUNOLOGY 64.5(2006):500-506.
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