|Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients|
|Bai, Yunkai1; Xiao, Hua1; Liu, Zhenhua1; Huang, Xiaoyan2,3; Tian, Xinkui4; Wang, Tao4; Zhe, Xingwei1|
|关键词||Arterial Stiffness Heart Rate Cvd|
|刊名||INTERNATIONAL UROLOGY AND NEPHROLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||ISOLATED SYSTOLIC HYPERTENSION ; STAGE RENAL-DISEASE ; CARDIOVASCULAR EVENTS ; BLOOD-PRESSURE ; RISK-FACTOR ; AORTIC STIFFNESS ; PREDICTIVE-VALUE ; YOUNG-ADULTS ; MORTALITY ; POPULATION|
Chronic kidney disease (CKD) is associated with high overall and cardiovascular mortality. Numerous studies have reported that increased heart rate is a risk factor for all-cause mortality. We investigated the link between sleep heart rate and artery stiffness in CKD patients.
In a cross-sectional study, we enrolled 100 prevalent Chinese CKD patients (55 males, aged 52.5 +/- A 16.40 years). Heart rate was measured with an automatic system. Arterial stiffness was evaluated by using a calibrated tonometer.
Large artery elasticity index (LAEI) was positively correlated with body mass index and hemoglobin but negatively associated with age and systolic blood pressure. Furthermore, LAEI was negatively associated with glomerular filtration rate (GFR) and sleep heart rate. In multivariate regression, LAEI was independently predicted by SBP, BMI, age, sleep heart rate, and gender. Adjusted R (2) of the model was 0.486.
Elevated sleep heart rate is significantly associated with increased arterial stiffness in CKD patients. Further investigation is needed to explore the potential benefits of sleep heart rate lowering therapy in this patient group.
|项目编号||2007bs08 ; 08S090104 ; 2008ZC127 M ; 36-1 ; 38-18 ; BSD-06-5-24 ; YLZD 06-5-27|
|资助机构||First Affiliated Hospital of Kunming Medical University ; Science and Technology Key Projects Grant Kunming Science and Technology Bureau ; Social Development Science and Technology Department of Yunnan Province ; Cheung Kong Scholar Programme, Ministry of Education, People&prime ; s Republic of China ; National "211 project" Grant ; Ministry of Education, People&prime ; s Republic of China ; Clinical Research Program (Peking University Third Hospital)|
|作者单位||1.Kunming Med Univ, Affiliated Hosp 1, Div Nephrol, Kunming 650032, Yunnan Province, Peoples R China|
2.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
3.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, Sweden
4.Peking Univ, Hosp 3, Div Nephrol, Beijing 100871, Peoples R China
|Bai, Yunkai,Xiao, Hua,Liu, Zhenhua,et al. Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients[J]. INTERNATIONAL UROLOGY AND NEPHROLOGY,2013,45(6):1621-1627.|
|APA||Bai, Yunkai.,Xiao, Hua.,Liu, Zhenhua.,Huang, Xiaoyan.,Tian, Xinkui.,...&Zhe, Xingwei.(2013).Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients.INTERNATIONAL UROLOGY AND NEPHROLOGY,45(6),1621-1627.|
|MLA||Bai, Yunkai,et al."Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients".INTERNATIONAL UROLOGY AND NEPHROLOGY 45.6(2013):1621-1627.|