北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 肾内科  > 期刊论文
学科主题: 临床医学
题名:
Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients
作者: Bai, Yunkai1; Xiao, Hua1; Liu, Zhenhua1; Huang, Xiaoyan2,3; Tian, Xinkui4; Wang, Tao4; Zhe, Xingwei1
关键词: Arterial stiffness ; Heart rate ; CVD
刊名: INTERNATIONAL UROLOGY AND NEPHROLOGY
发表日期: 2013-12-01
DOI: 10.1007/s11255-013-0431-1
卷: 45, 期:6, 页:1621-1627
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ISOLATED SYSTOLIC HYPERTENSION ; STAGE RENAL-DISEASE ; CARDIOVASCULAR EVENTS ; BLOOD-PRESSURE ; RISK-FACTOR ; AORTIC STIFFNESS ; PREDICTIVE-VALUE ; YOUNG-ADULTS ; MORTALITY ; POPULATION
英文摘要:

Chronic kidney disease (CKD) is associated with high overall and cardiovascular mortality. Numerous studies have reported that increased heart rate is a risk factor for all-cause mortality. We investigated the link between sleep heart rate and artery stiffness in CKD patients.

In a cross-sectional study, we enrolled 100 prevalent Chinese CKD patients (55 males, aged 52.5 +/- A 16.40 years). Heart rate was measured with an automatic system. Arterial stiffness was evaluated by using a calibrated tonometer.

Large artery elasticity index (LAEI) was positively correlated with body mass index and hemoglobin but negatively associated with age and systolic blood pressure. Furthermore, LAEI was negatively associated with glomerular filtration rate (GFR) and sleep heart rate. In multivariate regression, LAEI was independently predicted by SBP, BMI, age, sleep heart rate, and gender. Adjusted R (2) of the model was 0.486.

Elevated sleep heart rate is significantly associated with increased arterial stiffness in CKD patients. Further investigation is needed to explore the potential benefits of sleep heart rate lowering therapy in this patient group.

语种: 英语
所属项目编号: 2007bs08 ; 08S090104 ; 2008ZC127 M ; 36-1 ; 38-18 ; BSD-06-5-24 ; YLZD 06-5-27
项目资助者: First Affiliated Hospital of Kunming Medical University ; Science and Technology Key Projects Grant Kunming Science and Technology Bureau ; Social Development Science and Technology Department of Yunnan Province ; Cheung Kong Scholar Programme, Ministry of Education, People&prime ; s Republic of China ; National "211 project" Grant ; Ministry of Education, People&prime ; s Republic of China ; Clinical Research Program (Peking University Third Hospital)
WOS记录号: WOS:000327950000012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52506
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Kunming Med Univ, Affiliated Hosp 1, Div Nephrol, Kunming 650032, Yunnan Province, Peoples R China
2.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
3.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, Sweden
4.Peking Univ, Hosp 3, Div Nephrol, Beijing 100871, Peoples R China

Recommended Citation:
Bai, Yunkai,Xiao, Hua,Liu, Zhenhua,et al. Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients[J]. INTERNATIONAL UROLOGY AND NEPHROLOGY,2013,45(6):1621-1627.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Bai, Yunkai]'s Articles
[Xiao, Hua]'s Articles
[Liu, Zhenhua]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Bai, Yunkai]‘s Articles
[Xiao, Hua]‘s Articles
[Liu, Zhenhua]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace