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学科主题临床医学
Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients
Bai, Yunkai1; Xiao, Hua1; Liu, Zhenhua1; Huang, Xiaoyan2,3; Tian, Xinkui4; Wang, Tao4; Zhe, Xingwei1
关键词Arterial Stiffness Heart Rate Cvd
刊名INTERNATIONAL UROLOGY AND NEPHROLOGY
2013-12-01
DOI10.1007/s11255-013-0431-1
45期:6页:1621-1627
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]ISOLATED SYSTOLIC HYPERTENSION ; STAGE RENAL-DISEASE ; CARDIOVASCULAR EVENTS ; BLOOD-PRESSURE ; RISK-FACTOR ; AORTIC STIFFNESS ; PREDICTIVE-VALUE ; YOUNG-ADULTS ; MORTALITY ; POPULATION
英文摘要

Chronic kidney disease (CKD) is associated with high overall and cardiovascular mortality. Numerous studies have reported that increased heart rate is a risk factor for all-cause mortality. We investigated the link between sleep heart rate and artery stiffness in CKD patients.

In a cross-sectional study, we enrolled 100 prevalent Chinese CKD patients (55 males, aged 52.5 +/- A 16.40 years). Heart rate was measured with an automatic system. Arterial stiffness was evaluated by using a calibrated tonometer.

Large artery elasticity index (LAEI) was positively correlated with body mass index and hemoglobin but negatively associated with age and systolic blood pressure. Furthermore, LAEI was negatively associated with glomerular filtration rate (GFR) and sleep heart rate. In multivariate regression, LAEI was independently predicted by SBP, BMI, age, sleep heart rate, and gender. Adjusted R (2) of the model was 0.486.

Elevated sleep heart rate is significantly associated with increased arterial stiffness in CKD patients. Further investigation is needed to explore the potential benefits of sleep heart rate lowering therapy in this patient group.

语种英语
WOS记录号WOS:000327950000012
项目编号2007bs08 ; 08S090104 ; 2008ZC127 M ; 36-1 ; 38-18 ; BSD-06-5-24 ; YLZD 06-5-27
资助机构First Affiliated Hospital of Kunming Medical University ; Science and Technology Key Projects Grant Kunming Science and Technology Bureau ; Social Development Science and Technology Department of Yunnan Province ; Cheung Kong Scholar Programme, Ministry of Education, People&prime ; s Republic of China ; National "211 project" Grant ; Ministry of Education, People&prime ; s Republic of China ; Clinical Research Program (Peking University Third Hospital)
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52506
专题北京大学第三临床医学院_肾内科
北京大学公共卫生学院_公共卫生学院
作者单位1.Kunming Med Univ, Affiliated Hosp 1, Div Nephrol, Kunming 650032, Yunnan Province, Peoples R China
2.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
3.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, Sweden
4.Peking Univ, Hosp 3, Div Nephrol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Bai, Yunkai,Xiao, Hua,Liu, Zhenhua,et al. Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients[J]. INTERNATIONAL UROLOGY AND NEPHROLOGY,2013,45(6):1621-1627.
APA Bai, Yunkai.,Xiao, Hua.,Liu, Zhenhua.,Huang, Xiaoyan.,Tian, Xinkui.,...&Zhe, Xingwei.(2013).Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients.INTERNATIONAL UROLOGY AND NEPHROLOGY,45(6),1621-1627.
MLA Bai, Yunkai,et al."Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients".INTERNATIONAL UROLOGY AND NEPHROLOGY 45.6(2013):1621-1627.
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