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A comparative study on the diversity of clinical features between the sero-negative and sero-positive rheumatoid arthritis patients
Geng, Yan; Zhou, Wei; Zhang, Zhuo-li
关键词Rheumatoid Arthritis Sero-negative Sero-positive Clinical Feature
刊名RHEUMATOLOGY INTERNATIONAL
2012-12-01
DOI10.1007/s00296-011-2329-5
32期:12页:3897-3901
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]EXTRAARTICULAR MANIFESTATIONS ; CCP ANTIBODIES ; DISEASE ; PROGRESSION
英文摘要

To investigate the similarities and differences in clinical features between the sero-negative and sero-positive rheumatoid arthritis (RA) patients. Two hundred and sixty-two RA patients who fulfilled the 1987 ACR RA Classification Criteria were enrolled into this study. They were divided into sero-negative and sero-positive group depending on the presence or absence of rheumatoid factor (RF) and anti-cyclic citrullinate peptide (anti-CCP). The clinical features were compared between these two groups. Forty-six (17.6%) RA patients were classified as sero-negative group. The disease onset of sero-negative RA patients was later than that of sero-positive RA patients (52.4 +/- A 15.9 vs. 47.4 +/- A 15.5 years, P < 0.05). At the end of the first 2 years after disease onset, bone erosion shown in the hand X-ray occurred in 4 out of 24 (16.7%) patients with sero-negative RA. However, only 5.2% (5/97) patients with sero-positive RA developed bone erosion (P < 0.05). In the sero-positive RA patients, the titer of RF was correlated with swollen joint counts (SJC), tender joint counts (TJC), erythrocyte sedimentation rate (ESR), and disease activity score in 28 joints (DAS28) (P < 0.05), but anti-CCP was not. Sero-negative and sero-positive RA are probably two distinct disease subtypes driven by different mechanisms.

语种英语
WOS记录号WOS:000311515600028
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52513
专题北京大学第一临床医学院
作者单位Beijing Univ, Hosp 1, Dept Rheumatol & Clin Immunol, Beijing 100034, Peoples R China
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GB/T 7714
Geng, Yan,Zhou, Wei,Zhang, Zhuo-li. A comparative study on the diversity of clinical features between the sero-negative and sero-positive rheumatoid arthritis patients[J]. RHEUMATOLOGY INTERNATIONAL,2012,32(12):3897-3901.
APA Geng, Yan,Zhou, Wei,&Zhang, Zhuo-li.(2012).A comparative study on the diversity of clinical features between the sero-negative and sero-positive rheumatoid arthritis patients.RHEUMATOLOGY INTERNATIONAL,32(12),3897-3901.
MLA Geng, Yan,et al."A comparative study on the diversity of clinical features between the sero-negative and sero-positive rheumatoid arthritis patients".RHEUMATOLOGY INTERNATIONAL 32.12(2012):3897-3901.
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