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Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin
Li, Xinru1; Huang, Yanqing2; Chen, Xingwei1; Zhou, Yanxia1; Zhang, Yanhui1; Li, Pingzhu1; Liu, Yan1; Sun, Yufeng1; Zhao, Jieyu3; Wang, Fei1
关键词Pluronic P105 Polymeric Micelle Silybin Lactobionic Acid Liver Targeting Biodistribution Pharmacokinetics
刊名JOURNAL OF DRUG TARGETING
2009
DOI10.3109/10611860903062062
17期:10页:739-750
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PHENYL GLYCIDYL ETHER ; SYSTEM-RICH ORGANS ; POLYMERIC MICELLES ; BLOCK-COPOLYMERS ; AQUEOUS-SOLUTION ; DRUG-DELIVERY ; TRIBLOCK COPOLYMER ; CIRCULATION TIME ; ETHYLENE-OXIDE ; SOLUBILIZATION
英文摘要

Polymeric micelles, based on lactobionic acid (LA)-conjugated Pluronic P105 (P105), were prepared to achieve liver-targeted delivery of silybin. In the triblock copolymer structure of PEO-PPO-PEO, LA was successfully conjugated with the terminal end of PEO to produce LA-P105. The success of synthesis was confirmed using FTIR and (1)H NMR. The triblock copolymers with functional moiety were physically mixed with silybin to form micelles. Silybin-loaded LA-P105 micelles characterized by dynamic light scattering and transmission electron microscopy (TEM) were uniform spherical particles. There was a remarkable increase in the dissolubility for silybin in LA-P105 micelle solution (627 mu g/mL) when compared with that for water (4.6 mu g/mL). The pharmacokinetic experiments showed that the area under the curve of silybin plasma concentration-time profile in rats for LA-P105 micelles was lower than that for P105 micelles. Biodistribution studies indicated that a significantly increased amount of silybin was accumulated in liver, suggesting that LA locating on the surface of the micelles played an important role in transporting an increased amount of silybin into liver. This polymeric vehicle is, therefore, expected to be widely used as target-specific delivery vehicles for diverse water-insoluble therapeutic and diagnostic agents.

语种英语
WOS记录号WOS:000272538300002
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52515
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
3.Peking Univ, Pharmaceut Teaching Lab Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Xinru,Huang, Yanqing,Chen, Xingwei,et al. Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin[J]. JOURNAL OF DRUG TARGETING,2009,17(10):739-750.
APA Li, Xinru.,Huang, Yanqing.,Chen, Xingwei.,Zhou, Yanxia.,Zhang, Yanhui.,...&Wang, Fei.(2009).Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin.JOURNAL OF DRUG TARGETING,17(10),739-750.
MLA Li, Xinru,et al."Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin".JOURNAL OF DRUG TARGETING 17.10(2009):739-750.
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