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学科主题: 临床医学
题名:
Gender-specific reference value of urine albumin-creatinine ratio in healthy Chinese adults: Results of the Beijing CKD survey
作者: Xu, Rong2; Zhang, LuXia2; Zhang, PuHong3,4; Wang, Fang2; Zuo, Li2; Zhou, Ying3,4; Shi, Ying3,4; Li, Gang3,4; Jiao, ShuFang3,4; Liu, ZeJun3,4; Xu, GuoBin1; Liang, WanNian5; Wang, HaiYan2
关键词: Reference value ; Urine albumin-creatinine ratio ; Chinese ; Chronic kidney disease
刊名: CLINICA CHIMICA ACTA
发表日期: 2008-12-01
DOI: 10.1016/j.cca.2008.09.002
卷: 398, 期:1-2, 页:125-129
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; DIETARY-PROTEIN INTAKE ; ALBUMIN/CREATININE RATIO ; SCREENING-TEST ; CARDIOVASCULAR-DISEASE ; DIABETIC-NEPHROPATHY ; EXCRETION ; MICROALBUMINURIA ; SPECIMEN ; RISK
英文摘要:

Background: The reference value of urine albumin-creatinine ratio (ACR) has racial disparities. The ACR reference value in a healthy Beijing population is reported.

Methods: A reference Beijing population was sampled via a multistage. clustered complex sampling method. By excluding subjects with self-reported kidney disease, hypertension, diabetes, dyslipidemia, cardiovascular disease, obesity or underweight condition, overt proteinuria, hematuria, or pyuria, as well as those with an estimated glomerular filtration rate (eGFR) > 200ml/min/1.73m(2) or < 60ml/min/1.73m(2), apparently healthy subjects (1260 males, 2305 females, aged 18-84y) were selected to be included in the current analysis. Urine albumin was measured using the immunoturbidimetic method, creatinine was measured using Jaffe′s kinetic method on a morning spot-urine sample, and ACR was calculated. The 95th percentile of ACR was used as the normal upper limit. The association between ACR and each of gender, age, systolic blood pressure, body mass index, serum glucose, lipids, and eGFR was examined.

Results: The normal upper limit of ACR was 14mg/g (1.58mg/mmol) for males and 20mg/g (2.26mg/mmol) for females. Females had higher ACR values than males, and age, systolic blood pressure, and eGFR were positively correlated with ACR.

Conclusions: The ACR reference value in the healthy Beijing population is lower than that of the Western population. Age, systolic blood pressure, and eGFR were found to correlate with ACR. (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
项目资助者: International Society of Nephrology Research Committee ; China Health and Medical Development Foundation ; Beijing Municipal Science and Technology Commission
WOS记录号: WOS:000261074200025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52517
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Clin Lab, Beijing 100034, Peoples R China
2.Beijing Ctr Dis Control & Preven CDC, Beijing, Peoples R China
3.Ctr Prevent Med Res, Beijing, Peoples R China
4.Beijing Municipal Hlth Bur, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Xu, Rong,Zhang, LuXia,Zhang, PuHong,et al. Gender-specific reference value of urine albumin-creatinine ratio in healthy Chinese adults: Results of the Beijing CKD survey[J]. CLINICA CHIMICA ACTA,2008,398(1-2):125-129.
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