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学科主题: 临床医学
题名:
Molecular Biology of Atopic Dermatitis
作者: Mu, Zhanglei1; Zhao, Yan1; Liu, Xiaojing1; Chang, Christopher2; Zhang, Jianzhong1
关键词: Molecular biology ; Atopic dermatitis ; Eczema ; Filaggrin ; Cathelicidin ; Atopy ; Atopic march ; IgE ; Thymic stromal lymphopoeitin ; Tumor necrosis factor-alpha
刊名: CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
发表日期: 2014-10-01
DOI: 10.1007/s12016-014-8415-1
卷: 47, 期:2, 页:193-218
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Allergy ; Immunology
研究领域[WOS]: Allergy ; Immunology
关键词[WOS]: THYMIC STROMAL LYMPHOPOIETIN ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; GENOME-WIDE ASSOCIATION ; OF-FUNCTION MUTATIONS ; SKIN BARRIER FUNCTION ; EOSINOPHIL-DERIVED NEUROTOXIN ; SERUM IGE LEVELS ; TOLL-LIKE RECEPTOR-2 ; NF-KAPPA-B ; CD14 PROMOTER POLYMORPHISMS
英文摘要:

Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific genetic and immunological mechanisms. The rapid development of new techniques in molecular biology had ushered in new discoveries on the role of cytokines, chemokines, and immune cells in the pathogenesis of AD. New polymorphisms of AD are continually being reported in different populations. The physical and immunological barrier of normal intact skin is an important part of the innate immune system that protects the host against microbials and allergens that are associated with AD. Defects in the filaggrin gene FLG may play a role in facilitating exposure to allergens and microbial pathogens, which may induce Th2 polarization. Meanwhile, Th22 cells also play roles in skin barrier impairment through IL-22, and AD is often considered to be a Th2/Th22-dominant allergic disease. Mast cells and eosinophils are also involved in the inflammation via Th2 cytokines. Release of pruritogenic substances by mast cells induces scratching that further disrupts the skin barrier. Th1 and Th17 cells are mainly involved in chronic phase of AD. Keratinocytes also produce proinflammatory cytokines such as thymic stromal lymphopoietin (TSLP), which can further affect Th cells balance. The immunological characteristics of AD may differ for various endotypes and phenotypes. Due to the heterogeneity of the disease, and the redundancies of these mechanisms, our knowledge of the pathophysiology of the disease is still incomplete, which is reflected by the absence of a cure for the disease.

语种: 英语
WOS记录号: WOS:000342145600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52523
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

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作者单位: 1.Peking Univ Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
2.Thomas Jefferson Univ, Div Allergy & Immunol, Nemours AI duPont Hosp Children, Wilmington, DE 19803 USA

Recommended Citation:
Mu, Zhanglei,Zhao, Yan,Liu, Xiaojing,et al. Molecular Biology of Atopic Dermatitis[J]. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY,2014,47(2):193-218.
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