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学科主题: 精神卫生
题名:
Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia
作者: Takahashi, Sakae2; Cui, Yu-hu11; Han, Yong-hua11; Fagerness, Jesen A.9,10; Galloway, Brian9,10; Shen, Yu-cun11; Kojima, Takuya2; Uchiyama, Makoto2; Faraone, Stephen V.8; Tsuang, Ming T.1,3,4,5,6,7
关键词: schizophrenia ; chromosome 22 ; APOL gene family cluster ; APOL1 ; AOPL2 ; APOL4
刊名: SCHIZOPHRENIA RESEARCH
发表日期: 2008-09-01
DOI: 10.1016/j.schres.2008.05.028
卷: 104, 期:1-3, 页:153-164
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: D22S278 MARKER ALLELES ; GENOME-WIDE SEARCH ; SUSCEPTIBILITY LOCUS ; TRANSMISSION DISEQUILIBRIUM ; AFRICAN-AMERICAN ; LINKAGE ANALYSIS ; CHROMOSOME-22 ; FAMILY ; GENE ; HETEROGENEITY
英文摘要:

Prior work found the A POL1, 2 and 4 genes, located on chromosome 22q12.3-q113.1, to be upreaulated in brains of schizophrenic patients, We performed a family-based association study using 130 SNPs tagging the APOL gene family (APOL1-6). The Subjects were 112 African-American (AA), 114 European-American (EA), 109 Chinese (Ch) and 42 Japanese (Jp) families with schizophrenia (377 families, 1161 genotyped members and 647 genotyped affected in total). Seven SNPs had p-values< 0.05 in the APOL1, 2 and 4 regions for the AA, EA and combined (AA and EA) samples. In the AA sample, two SNPs, rs9610449 and rs6000200 showed low p-values; and a haplotype which comprised these two SNPs yielded a p-value of 0.00029 using the global test (GT) and the allele specific test (AST). The two SNPs and the haplotype were associated with risk for schizophrenia in African-Americans. In the combined (AA and EA) sample, two SNPs, rs2003813 and rs2157249 showed low p-values; and a three SNP haplotype including these two SNPs was significant using the GT (p = 0.0013) and the AST (p = 0.000090). The association of this haplotype with schizophrenia was significant for the entire (AA, EA, Ch and Jp) sample using the GT (p = 0.00054) and the AST (p = 0.00011). Although our study is not definitive, it suggests that the APOL genes should be more extensively studied in schizophrenia, (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000259879700017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52525
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Nihon Univ, Sch Med, Dept Psychiat, Div Psychiat, Tokyo, Japan
2.Harvard Inst Psychiat Epidemiol & Genet, Boston, MA USA
3.Harvard Univ, Sch Med, Dept Psychiat, Charlestown, MA USA
4.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
5.Univ Calif San Diego, Dept Psychiat, Ctr Behav Genom, La Jolla, CA 92093 USA
6.Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Dept Psychiat, Boston, MA 02115 USA
7.Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USA
8.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
9.Univ Calif San Diego, San Diego, CA 92103 USA
10.SUNY Upstate Med Univ, Dept Psychiat & Neurosci & Physiol, Syracuse, NY USA
11.Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Charlestown, MA USA

Recommended Citation:
Takahashi, Sakae,Cui, Yu-hu,Han, Yong-hua,et al. Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2008,104(1-3):153-164.
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