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Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells
Zhang, Liang1; Yao, Hong-Juan1; Yu, Yang1; Zhang, Yan1; Li, Ruo-Jing1; Ju, Rui-Jun1; Wang, Xiao-Xing1; Sun, Meng-Ge1; Shi, Ji-Feng1; Lu, Wan-Liang1
关键词Relapse Of Breast Cancer Mitochondrial Targeting Daunorubicin Plus Quinacrine Liposomes Apoptosis Mitochondrial Signaling Pathway Breast Cancer Stem Cells
刊名BIOMATERIALS
2012
DOI10.1016/j.biomaterials.2011.09.055
33期:2页:565-582
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]IN-VITRO PROPAGATION ; CYTOCHROME-C ; STEM/PROGENITOR CELLS ; CARCINOMA-CELLS ; SIDE POPULATION ; APOPTOSIS ; LEUKEMIA ; PATHWAY ; INDUCTION ; TAMOXIFEN
英文摘要

Breast cancer stem cells play a crucial role in the relapse of breast cancers because they are resistant to a standard chemotherapy and the residual cancer stem cells are able to proliferate indefinitely. The objectives of present study were to construct a kind of mitochondrial targeting daunorubicin plus quinacrine liposomes for treating and for preventing the recurrence of breast cancer arising from the cancer stem cells. MCF-7 cancer stem cells were identified as CD44(+)/CD24(-) cells and cultured in free-serum medium. Evaluations were performed on MCF-7 cancer stem cells, MCF-7 cancer stem cell mammospheres, and the relapsed tumor by xenografting MCF-7 cancer stem cells into female NOD/SCID mice. The particle size of mitochondrial targeting daunorubicin plus quinacrine liposomes was approximately 98 nm. The mitochondrial targeting liposomes evidently increased the mitochondrial uptake of drugs, were selectively accumulated into mitochondria, activated the pro-apoptotic Bax protein, dissipated the mitochondrial membrane potential, opened the mitochondrial permeability transition pores, released cytochrome C by translocation, and initiated a cascade of caspase 9 and 3 reactions, thereby inducing apoptosis of MCF-7 cancer stem cells. The mitochondrial targeting liposomes showed the strongest efficacy in treating MCF-7 cancer cells in vitro, in treating MCF-7 cancer stem cells in vitro, and in treating the relapsed tumor in mice. Mitochondrial targeting daunorubicin plus quinacrine liposomes would provide a new strategy for treating and preventing the relapse of breast cancers arising from cancer stem cells. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000297879200021
项目编号7091005 ; 2009CB930300 ; 81172991
资助机构Beijing Natural Science Foundation ; National Key Science Research Program of China (973 program) ; National Natural Science Foundation of China
引用统计
被引频次:63[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52527
专题北京大学药学院
北京大学第二临床医学院_麻醉科
北京大学第三临床医学院_麻醉科
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Liang,Yao, Hong-Juan,Yu, Yang,et al. Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells[J]. BIOMATERIALS,2012,33(2):565-582.
APA Zhang, Liang.,Yao, Hong-Juan.,Yu, Yang.,Zhang, Yan.,Li, Ruo-Jing.,...&Lu, Wan-Liang.(2012).Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells.BIOMATERIALS,33(2),565-582.
MLA Zhang, Liang,et al."Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells".BIOMATERIALS 33.2(2012):565-582.
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