北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells
作者: Zhang, Liang1; Yao, Hong-Juan1; Yu, Yang1; Zhang, Yan1; Li, Ruo-Jing1; Ju, Rui-Jun1; Wang, Xiao-Xing1; Sun, Meng-Ge1; Shi, Ji-Feng1; Lu, Wan-Liang1
关键词: Relapse of breast cancer ; Mitochondrial targeting daunorubicin plus quinacrine liposomes ; Apoptosis ; Mitochondrial signaling pathway ; Breast cancer stem cells
刊名: BIOMATERIALS
发表日期: 2012
DOI: 10.1016/j.biomaterials.2011.09.055
卷: 33, 期:2, 页:565-582
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: IN-VITRO PROPAGATION ; CYTOCHROME-C ; STEM/PROGENITOR CELLS ; CARCINOMA-CELLS ; SIDE POPULATION ; APOPTOSIS ; LEUKEMIA ; PATHWAY ; INDUCTION ; TAMOXIFEN
英文摘要:

Breast cancer stem cells play a crucial role in the relapse of breast cancers because they are resistant to a standard chemotherapy and the residual cancer stem cells are able to proliferate indefinitely. The objectives of present study were to construct a kind of mitochondrial targeting daunorubicin plus quinacrine liposomes for treating and for preventing the recurrence of breast cancer arising from the cancer stem cells. MCF-7 cancer stem cells were identified as CD44(+)/CD24(-) cells and cultured in free-serum medium. Evaluations were performed on MCF-7 cancer stem cells, MCF-7 cancer stem cell mammospheres, and the relapsed tumor by xenografting MCF-7 cancer stem cells into female NOD/SCID mice. The particle size of mitochondrial targeting daunorubicin plus quinacrine liposomes was approximately 98 nm. The mitochondrial targeting liposomes evidently increased the mitochondrial uptake of drugs, were selectively accumulated into mitochondria, activated the pro-apoptotic Bax protein, dissipated the mitochondrial membrane potential, opened the mitochondrial permeability transition pores, released cytochrome C by translocation, and initiated a cascade of caspase 9 and 3 reactions, thereby inducing apoptosis of MCF-7 cancer stem cells. The mitochondrial targeting liposomes showed the strongest efficacy in treating MCF-7 cancer cells in vitro, in treating MCF-7 cancer stem cells in vitro, and in treating the relapsed tumor in mice. Mitochondrial targeting daunorubicin plus quinacrine liposomes would provide a new strategy for treating and preventing the relapse of breast cancers arising from cancer stem cells. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 7091005 ; 2009CB930300 ; 81172991
项目资助者: Beijing Natural Science Foundation ; National Key Science Research Program of China (973 program) ; National Natural Science Foundation of China
WOS记录号: WOS:000297879200021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52527
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Liang,Yao, Hong-Juan,Yu, Yang,et al. Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells[J]. BIOMATERIALS,2012,33(2):565-582.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Liang]'s Articles
[Yao, Hong-Juan]'s Articles
[Yu, Yang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Liang]‘s Articles
[Yao, Hong-Juan]‘s Articles
[Yu, Yang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace