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学科主题: 临床医学
题名:
Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells
作者: Du, Wei1; Pang, Changhe1; Xue, Yake1; Zhang, Qingjun2; Wei, Xinting1
关键词: dihydroartemisinin ; glioma ; dual pathway inhibitor ; Raf/MEK/ERK ; PI3K/AKT
刊名: Oncology Letters
发表日期: 2015-11-01
DOI: 10.3892/ol.2015.3699
卷: 10, 期:5, 页:3266-3270
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CANCER CELLS ; GROWTH ; APOPTOSIS ; MEK ; ERK ; RAF/MEK/ERK ; MODULATION ; AUTOPHAGY ; LEUKEMIA ; THERAPY
英文摘要:

It has previously been reported that dihydroartemisinin (DHA) is an effective novel anticancer compound in a number of types of tumor cells. Previous studies have demonstrated the anticancer activity of DHA in gioma cells. However, its underlining mechanism remains unclear. In the present study, the anticancer activity of DHA was examined in the glioma cell lines BT325 and C6. Western blot analysis was also employed to determine the signaling pathway changes. It was demonstrated that DHA effectively inhibited cell growth and induced apoptosis in glioma cells. Moreover, western blot analysis indicated that DHA-induced apoptosis was accompanied by inactivation of the Raf/MEK/ERK and PI3K/AKT signaling pathways, in addition to the downregulation of anti-apoptotic proteins Mcl-1 and Bcl-2 expression levels.

语种: 英语
WOS记录号: WOS:000364324800098
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52532
Appears in Collections:北京大学第二临床医学院_神经外科_期刊论文

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作者单位: 1.Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100044, Peoples R China

Recommended Citation:
Du, Wei,Pang, Changhe,Xue, Yake,et al. Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells[J]. Oncology Letters,2015,10(5):3266-3270.
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