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学科主题临床医学
Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells
Du, Wei1; Pang, Changhe1; Xue, Yake1; Zhang, Qingjun2; Wei, Xinting1
关键词Dihydroartemisinin Glioma Dual Pathway Inhibitor Raf/mek/erk Pi3k/akt
刊名Oncology Letters
2015-11-01
DOI10.3892/ol.2015.3699
10期:5页:3266-3270
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CANCER CELLS ; GROWTH ; APOPTOSIS ; MEK ; ERK ; RAF/MEK/ERK ; MODULATION ; AUTOPHAGY ; LEUKEMIA ; THERAPY
英文摘要

It has previously been reported that dihydroartemisinin (DHA) is an effective novel anticancer compound in a number of types of tumor cells. Previous studies have demonstrated the anticancer activity of DHA in gioma cells. However, its underlining mechanism remains unclear. In the present study, the anticancer activity of DHA was examined in the glioma cell lines BT325 and C6. Western blot analysis was also employed to determine the signaling pathway changes. It was demonstrated that DHA effectively inhibited cell growth and induced apoptosis in glioma cells. Moreover, western blot analysis indicated that DHA-induced apoptosis was accompanied by inactivation of the Raf/MEK/ERK and PI3K/AKT signaling pathways, in addition to the downregulation of anti-apoptotic proteins Mcl-1 and Bcl-2 expression levels.

语种英语
WOS记录号WOS:000364324800098
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52532
专题北京大学第二临床医学院_神经外科
作者单位1.Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100044, Peoples R China
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Du, Wei,Pang, Changhe,Xue, Yake,et al. Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells[J]. Oncology Letters,2015,10(5):3266-3270.
APA Du, Wei,Pang, Changhe,Xue, Yake,Zhang, Qingjun,&Wei, Xinting.(2015).Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells.Oncology Letters,10(5),3266-3270.
MLA Du, Wei,et al."Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells".Oncology Letters 10.5(2015):3266-3270.
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