北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
CCL2-2518 (A/G) polymorphisms and tuberculosis susceptibility: a meta-analysis
作者: Feng, W-X.1; Flores-Villanueva, P. O.2; Mokrousov, I.3; Wu, X-R.1; Xiao, J.1; Jiao, W-W.1; Sun, L.1; Miao, Q.1; Shen, C.1; Shen, D.1; Liu, F.1; Jia, Z-W.4; Shen, A.1
关键词: tuberculosis ; polymorphism (genetics) ; CCL2 ; MCP-1 ; meta-analysis
刊名: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
发表日期: 2012-02-01
DOI: 10.5588/ijtld.11.0205
卷: 16, 期:2, 页:150-156
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Respiratory System
研究领域[WOS]: Infectious Diseases ; Respiratory System
关键词[WOS]: PULMONARY TUBERCULOSIS ; MYCOBACTERIUM-TUBERCULOSIS ; GENE POLYMORPHISMS ; CC-CHEMOKINE ; MCP-1 ; PROMOTER ; ASSOCIATION ; POPULATION ; CHINESE ; INNATE
英文摘要:

BACKGROUND: It has been found that the -2518 C-C motif ligand (CCL)-2 promoter variant increases the risk of developing active tuberculosis (TB).

OBJECTIVE: To study the association between -2518 variants and susceptibility to TB.

DESIGN: We searched Medline, PubMed and the Wan Fang databases for human genetic studies on whether the -2518 CCL2 polymorphism influences the expression of active TB. Articles published from January 1998 to November 2010 were included. A random effects model was conducted in the meta-analysis.

RESULTS: The CCL2-2518G allele (OR 1.51, 95%CI 1.11-2.04, P = 0.008) showed significant association with susceptibility to TB. In genotype analysis, the recessive model (CCL2 genotype GG, OR 1.66, 95%CI 1.19-2.33, P = 0.003) was slightly superior to the dominant model (G carrier genotypes OR 1.53, 95%CI 1.07-2.17, P = 0.018). These observations were prominent among Asians and Latin-Americans of Hispanic ancestry, but not in Africans from Ghana and South Africa. The presence of epistatic genes in one population but not in the other, environmental differences and pathogen virulence may account for this.

CONCLUSION: The CCL2-2518G allele increases the risk of developing TB in Asians and Hispanics.

语种: 英语
所属项目编号: 30672258 ; 30872788 ; 30973981 ; 81071315 ; Z09050700940903 ; R01-HL084347 ; 11-04-91172
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; USA National Institutes of Health ; Russian Foundation for Basic Research
WOS记录号: WOS:000299666000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52533
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Methodist Hosp, Res Inst, Houston, TX 77030 USA
2.St Petersburg Pasteur Inst, Mol Microbiol Lab, St Petersburg, Russia
3.Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst,Minist Educ, Key Lab Major Dis Children,Natl Key Discipline Pa, Beijing 100045, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Feng, W-X.,Flores-Villanueva, P. O.,Mokrousov, I.,et al. CCL2-2518 (A/G) polymorphisms and tuberculosis susceptibility: a meta-analysis[J]. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE,2012,16(2):150-156.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Feng, W-X.]'s Articles
[Flores-Villanueva, P. O.]'s Articles
[Mokrousov, I.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Feng, W-X.]‘s Articles
[Flores-Villanueva, P. O.]‘s Articles
[Mokrousov, I.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace