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CCL2-2518 (A/G) polymorphisms and tuberculosis susceptibility: a meta-analysis
Feng, W-X.1; Flores-Villanueva, P. O.2; Mokrousov, I.3; Wu, X-R.1; Xiao, J.1; Jiao, W-W.1; Sun, L.1; Miao, Q.1; Shen, C.1; Shen, D.1; Liu, F.1; Jia, Z-W.4; Shen, A.1
关键词Tuberculosis Polymorphism (Genetics) Ccl2 Mcp-1 Meta-analysis
刊名INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
2012-02-01
DOI10.5588/ijtld.11.0205
16期:2页:150-156
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Respiratory System
资助者National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; USA National Institutes of Health ; Russian Foundation for Basic Research ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; USA National Institutes of Health ; Russian Foundation for Basic Research
研究领域[WOS]Infectious Diseases ; Respiratory System
关键词[WOS]PULMONARY TUBERCULOSIS ; MYCOBACTERIUM-TUBERCULOSIS ; GENE POLYMORPHISMS ; CC-CHEMOKINE ; MCP-1 ; PROMOTER ; ASSOCIATION ; POPULATION ; CHINESE ; INNATE
英文摘要

BACKGROUND: It has been found that the -2518 C-C motif ligand (CCL)-2 promoter variant increases the risk of developing active tuberculosis (TB).

OBJECTIVE: To study the association between -2518 variants and susceptibility to TB.

DESIGN: We searched Medline, PubMed and the Wan Fang databases for human genetic studies on whether the -2518 CCL2 polymorphism influences the expression of active TB. Articles published from January 1998 to November 2010 were included. A random effects model was conducted in the meta-analysis.

RESULTS: The CCL2-2518G allele (OR 1.51, 95%CI 1.11-2.04, P = 0.008) showed significant association with susceptibility to TB. In genotype analysis, the recessive model (CCL2 genotype GG, OR 1.66, 95%CI 1.19-2.33, P = 0.003) was slightly superior to the dominant model (G carrier genotypes OR 1.53, 95%CI 1.07-2.17, P = 0.018). These observations were prominent among Asians and Latin-Americans of Hispanic ancestry, but not in Africans from Ghana and South Africa. The presence of epistatic genes in one population but not in the other, environmental differences and pathogen virulence may account for this.

CONCLUSION: The CCL2-2518G allele increases the risk of developing TB in Asians and Hispanics.

语种英语
所属项目编号30672258 ; 30872788 ; 30973981 ; 81071315 ; Z09050700940903 ; R01-HL084347 ; 11-04-91172
资助者National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; USA National Institutes of Health ; Russian Foundation for Basic Research ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; USA National Institutes of Health ; Russian Foundation for Basic Research
WOS记录号WOS:000299666000003
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52533
专题中国药物依赖性研究所
作者单位1.Methodist Hosp, Res Inst, Houston, TX 77030 USA
2.St Petersburg Pasteur Inst, Mol Microbiol Lab, St Petersburg, Russia
3.Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst,Minist Educ, Key Lab Major Dis Children,Natl Key Discipline Pa, Beijing 100045, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
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GB/T 7714
Feng, W-X.,Flores-Villanueva, P. O.,Mokrousov, I.,et al. CCL2-2518 (A/G) polymorphisms and tuberculosis susceptibility: a meta-analysis[J]. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE,2012,16(2):150-156.
APA Feng, W-X..,Flores-Villanueva, P. O..,Mokrousov, I..,Wu, X-R..,Xiao, J..,...&Shen, A..(2012).CCL2-2518 (A/G) polymorphisms and tuberculosis susceptibility: a meta-analysis.INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE,16(2),150-156.
MLA Feng, W-X.,et al."CCL2-2518 (A/G) polymorphisms and tuberculosis susceptibility: a meta-analysis".INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 16.2(2012):150-156.
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