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学科主题: 基础医学
题名:
LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells
作者: Liu, Xinrong; Xiong, Fuxia; Wei, Xuanhui; Yang, Hua; Zhou, Rouli
刊名: CANCER SCIENCE
发表日期: 2009-12-01
DOI: 10.1111/j.1349-7006.2009.01346.x
卷: 100, 期:12, 页:2335-2340
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HUMAN BREAST-CANCER ; C-MYC ; CYCLIN-E ; EXPRESSION ; GENE ; ACTIVATION ; FAMILY ; IDENTIFICATION ; TUMORIGENESIS ; TRANSCRIPTION
英文摘要:

Lysosomal protein transmembrane 4 beta (LAPTM4B) was originally identified as a hepatocellular carcinoma (HCC)-associated gene. This gene and its protein product LAPTM4B-35, are both overexpressed in a variety of human cancers. However, its specific role in cell transformation and malignancy has remained elusive. In the present study we investigated the effects of LAPTM4B-35 overexpression on the malignant phenotypic features in the HLE cell line. Our data show that overexpression of LAPTM4B-35 promotes cell proliferation, exogenous growth-stimulating factor-independent and anchorage-independent growth, and enhances metastatic potential, including promotion of both cell migration and invasion. Study of the underlying mechanisms demonstrated alterations of molecular events involved in these processes, which included upregulation of proliferation-promoting transcription factors such as c-Myc, c-Jun, and c-Fos, and cell cycle-promoting proteins such as cyclin D1 and cyclin E. In addition, mutagenesis study showed that the PPRP motif in the N-terminal region of LAPTM4B-35 plays a critical role in promoting proliferation, migration, and invasion, as well as in the upregulation of the oncoproteins noted above. These data offer insight into the mechanism by which this novel tetratransmembrane protein contributes to the pathogenesis of liver cancer, and suggest that it may be a potential target for cancer therapy. (Cancer Sci 2009).

语种: 英语
所属项目编号: H020220020310 ; 7041003
项目资助者: Special Fund for Promotion of Education, Ministry of Education ; 248 major R&amp ; D program of Beijing ; Natural Science Foundation of Beijing
WOS记录号: WOS:000271709300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52537
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Xinrong,Xiong, Fuxia,Wei, Xuanhui,et al. LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells[J]. CANCER SCIENCE,2009,100(12):2335-2340.
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