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学科主题基础医学
LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells
Liu, Xinrong; Xiong, Fuxia; Wei, Xuanhui; Yang, Hua; Zhou, Rouli
刊名CANCER SCIENCE
2009-12-01
DOI10.1111/j.1349-7006.2009.01346.x
100期:12页:2335-2340
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HUMAN BREAST-CANCER ; C-MYC ; CYCLIN-E ; EXPRESSION ; GENE ; ACTIVATION ; FAMILY ; IDENTIFICATION ; TUMORIGENESIS ; TRANSCRIPTION
英文摘要

Lysosomal protein transmembrane 4 beta (LAPTM4B) was originally identified as a hepatocellular carcinoma (HCC)-associated gene. This gene and its protein product LAPTM4B-35, are both overexpressed in a variety of human cancers. However, its specific role in cell transformation and malignancy has remained elusive. In the present study we investigated the effects of LAPTM4B-35 overexpression on the malignant phenotypic features in the HLE cell line. Our data show that overexpression of LAPTM4B-35 promotes cell proliferation, exogenous growth-stimulating factor-independent and anchorage-independent growth, and enhances metastatic potential, including promotion of both cell migration and invasion. Study of the underlying mechanisms demonstrated alterations of molecular events involved in these processes, which included upregulation of proliferation-promoting transcription factors such as c-Myc, c-Jun, and c-Fos, and cell cycle-promoting proteins such as cyclin D1 and cyclin E. In addition, mutagenesis study showed that the PPRP motif in the N-terminal region of LAPTM4B-35 plays a critical role in promoting proliferation, migration, and invasion, as well as in the upregulation of the oncoproteins noted above. These data offer insight into the mechanism by which this novel tetratransmembrane protein contributes to the pathogenesis of liver cancer, and suggest that it may be a potential target for cancer therapy. (Cancer Sci 2009).

语种英语
WOS记录号WOS:000271709300015
项目编号H020220020310 ; 7041003
资助机构Special Fund for Promotion of Education, Ministry of Education ; 248 major R&amp ; D program of Beijing ; Natural Science Foundation of Beijing
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52537
专题北京大学基础医学院_细胞生物学系
作者单位Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China
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GB/T 7714
Liu, Xinrong,Xiong, Fuxia,Wei, Xuanhui,et al. LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells[J]. CANCER SCIENCE,2009,100(12):2335-2340.
APA Liu, Xinrong,Xiong, Fuxia,Wei, Xuanhui,Yang, Hua,&Zhou, Rouli.(2009).LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells.CANCER SCIENCE,100(12),2335-2340.
MLA Liu, Xinrong,et al."LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells".CANCER SCIENCE 100.12(2009):2335-2340.
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