Institutional Repository of Peking University School of Basic Medical Sciences
|Allergic diseases, immunoglobulin E, and autoimmune pancreatitis: a retrospective study of 22 patients|
|Zhang Li1; Guo Limei3; Huang Yonghui1; Wang Tianli2; Shi Xueying3; Chang Hong1; Yao Wei1; Huang Xuebiao1|
|关键词||Hypersensitivity Pancreatitis Immunoglobulin e Mast Cells|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||DIAGNOSTIC-CRITERIA ; PROPOSAL ; CELLS ; IGE ; G4|
Background Autoimmune pancreatitis (AIP) is a chronic inflammatory disease of pancreas. We evaluated the clinical manifestations, imaging, and histological presentations of AIP in Chinese patients, and investigated the roles of immunoglobulin E (IgE) and allergic diseases in the diagnosis and pathogenesis of AIP.
Methods The clinical records of 22 patients diagnosed with AIP were reviewed and analyzed. All patients with AIP fulfilled the 2006 revised diagnostic criteria proposed by Japan Pancreas Society or the Korean Criteria for AIP.
Results Half (11/22) of AIP patients had allergic diseases. Twenty-one patients had elevated serum IgE levels, and 14 patients had IgE levels more than 3 times that of normal. There were no significant differences between the patients with higher or lower IgE, with or without allergic disease, in clinical features, laboratory tests, diffuse or focal lesions, or the choice of treatment methods; however, more complaints of body weight loss were observed in patients with higher IgE levels. Patients with higher IgE levels and with allergic diseases were more likely to have onset in March, April, May, August, September, or October. IgE levels decreased after therapy, but increased again during recurrence. Increased number of mast cells was found in the pancreatic tissue in AIP.
Conclusions IgE maybe a useful marker for monitoring therapeutic response and recurrence of AIP. Allergic processes may play an important role in the pathogenesis of AIP.
|作者单位||1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China|
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
|Zhang Li,Guo Limei,Huang Yonghui,et al. Allergic diseases, immunoglobulin E, and autoimmune pancreatitis: a retrospective study of 22 patients[J]. CHINESE MEDICAL JOURNAL,2014,127(23):4104-4109.|
|APA||Zhang Li.,Guo Limei.,Huang Yonghui.,Wang Tianli.,Shi Xueying.,...&Huang Xuebiao.(2014).Allergic diseases, immunoglobulin E, and autoimmune pancreatitis: a retrospective study of 22 patients.CHINESE MEDICAL JOURNAL,127(23),4104-4109.|
|MLA||Zhang Li,et al."Allergic diseases, immunoglobulin E, and autoimmune pancreatitis: a retrospective study of 22 patients".CHINESE MEDICAL JOURNAL 127.23(2014):4104-4109.|