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学科主题: 临床医学
题名:
Optimized project of traditional Chinese medicine in treating chronic kidney disease stage 3: A multicenter double-blinded randomized controlled trial
作者: Wang, Yong-jun1; He, Li-qun2; Sun, Wei3; Lu, Ying1; Wang, Xiao-qin4; Zhang, Pei-qing5; Wei, Lian-bo6; Cao, Shi-li7; Yang, Ni-zhi8; Ma, Hong-zhen9; Gao, Jing10; Li, Ping11; Tao, Xiao-juan12; Yuan, Fa-huan13; Li, Jing10; Yao, Chen14; Liu, Xusheng8
关键词: Chronic kidney disease ; Traditional Chinese medicine ; Fangjihuangqi decoction ; Dangguibuxue decoction ; Xiayuxue decoction ; Tufuling decoction ; Chronic renal failure
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2012-02-15
DOI: 10.1016/j.jep.2011.12.009
卷: 139, 期:3, 页:757-764
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: TGF-BETA-1-STIMULATED NRK-49F CELLS ; CHRONIC RENAL-INSUFFICIENCY ; IN-VITRO ; MATRIX SYNTHESIS ; DIABETIC-RATS ; ACID-B ; EMODIN ; NEPHROPATHY ; TETRANDRINE ; BENAZEPRIL
英文摘要:

Ethnopharmacological relevance: Stage 3 is the key phase of chronic kidney disease. Traditional Chinese medicine (TCM) has been used for the treatment of chronic kidney disease. But a large sample trial is desirable.

Materials and methods: A total of 578 Chinese patients with primary glomerulonephritis in CKD stage 3 were randomly assigned to three groups: patients received TCM (TCM group). benazepril (Ben group), TCM combined with benazepril (TCM + Ben group). Patients were followed up for 24 weeks. The primary endpoint was the time to the composite of 50% increased of serum creatinine, end stage renal disease or death.

Results: eGFR in the TCM and the TCM + Ben group were improved (week 24 vs. baseline, P < 0.05) while eGFR in the Ben group was decreased (week 24 vs. baseline, P > 0.05). 24 h urinary protein excretion (UP) and urinary albumin/creatinine (UAlb/Cr) were decreased in the TCM + Ben (week 24 vs. baseline, P < 0.05) and the Ben group (week 24 vs. baseline. P> 0.05). UP and UAlb/Cr were increased in the TCM group to week 12, then were stable (week 24 vs. baseline, P < 0.05). The hemoglobin in the TCM group was also improved (week 24 vs. baseline, P < 0.05). The accumulative survival rate in the TCM + Ben group was higher than that in the TCM group and the Ben group (P = 0.044). Side effects in the TCM group were the lowest in these groups (P < 0.05). The patients with dry cough in the TCM + Ben group and the Ben group were increased as compared with the TCM group (P < 0.05). Hyperkalemia happened less frequently in the TCM group as compared with the other two groups (P = 0.052).

Conclusions: For the patients with CKD stage 3, TCM can improve eGFR and hemoglobin with lower side effects. Benazepril significantly decreased the proteinuria. Chinese medicine integrated with benazepril can ameliorate renal function and decrease proteinuria synergistically. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2006BAI04A07
项目资助者: Chinese National Science and Technology Pillar Program
WOS记录号: WOS:000301900400014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52558
Appears in Collections:北京大学第一临床医学院_医学统计室_期刊论文

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作者单位: 1.Zhejiang Univ Chinese Med, Hangzhou Hosp Tradit Chinese Med, Dept Nephrol, Hangzhou 310007, Zhejiang, Peoples R China
2.Shanghai Univ Chinese Med, Shuguang Hosp, Dept Nephrol, Shanghai, Peoples R China
3.Jiangshu Univ Chinese Med, Affiliated Hosp, Dept Nephrol, Nanjing, Jiangsu, Peoples R China
4.Hubei Hosp Tradit Chinese Med, Dept Nephrol, Wuhan, Hubei Province, Peoples R China
5.Heilongjiang Acad Tradit Chinese Med, Dept Nephrol, Harbin, Heilongjiang Pr, Peoples R China
6.So Med Univ, Affiliated Zhujiang Hosp, Dept Nephrol, Guangzhou, Guangdong, Peoples R China
7.Tianjin Univ Tradit Chinese Med, Hosp 1, Dept Nephrol, Tianjin, Peoples R China
8.Guangdong Hosp Tradit Chinese Med, Dept Nephrol, Guangzhou, Guangdong, Peoples R China
9.Zhejiang Hosp Tradit Chinese Med, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
10.Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Nephrol, Beijing, Peoples R China
11.China Japan Friendship Hosp, Inst Clin Med Sci, Dept Pharmacol, Beijing, Peoples R China
12.Hangzhou Red Cross Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
13.Third Mil Med Univ, Xinqiao Hosp, Dept Nephrol, Chongqing, Peoples R China
14.Peking Univ, Affiliated Hosp 1, Dept Stat, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Yong-jun,He, Li-qun,Sun, Wei,et al. Optimized project of traditional Chinese medicine in treating chronic kidney disease stage 3: A multicenter double-blinded randomized controlled trial[J]. JOURNAL OF ETHNOPHARMACOLOGY,2012,139(3):757-764.
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