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Folic acid supplementation and cancer risk: A meta-analysis of randomized controlled trials
Qin, Xianhui1,2; Cui, Yimin3; Shen, Lin4; Sun, Ningling5; Zhang, Yan6; Li, Jianping6; Xu, Xin7; Wang, Binyan2; Xu, Xiping7; Huo, Yong6; Wang, Xiaobin8
关键词Folic Acid Supplementation Cancer Risk Randomized Controlled Trials Meta-analysis
刊名INTERNATIONAL JOURNAL OF CANCER
2013-09-01
DOI10.1002/ijc.28038
133期:5页:1033-1041
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]STAGE RENAL-DISEASE ; CARDIOVASCULAR EVENTS ; MYOCARDIAL-INFARCTION ; COLORECTAL ADENOMAS ; STROKE PREVENTION ; B-VITAMINS ; LOWERING HOMOCYSTEINE ; VASCULAR-DISEASE ; CLINICAL-TRIAL ; MORTALITY
英文摘要

There are growing data and a continuing controversy over the effect of folic acid supplementation on cancer risk. We conducted a meta-analysis based on up-to-date published relevant randomized trials to further examine this issue. Relative risk (RR) was used to measure the effect of folic acid supplementation on risk of cancer using a random-effects model. Overall, folic acid supplementation had no significant effect on total cancer incidence (13 trials, n=49,406, RR=1.05; 95% CI: 0.99-1.11, p=0.13), colorectal cancer (seven trials, n=33,824, 1.01; 0.82-1.23, p=0.95), other gastrointestinal cancer (two trials, n=20,228, 1.00; 0.75-1.33, p=0.99), prostate cancer (five trials, n=27,065, 1.17; 0.84-1.62, p=0.35), other genitourinary cancer (two trials, n=20,228, 0.97; 0.75-1.27, p=0.84), lung cancer (five trials, n=31,864, 1.00; 0.84-1.21, p=0.97), breast cancer (four trials, n=19,800, 0.82; 0.63-1.07, p=0.15), hematological malignancy (three trials, n=25,670, 0.87; 0.64-1.17, p=0.35) and total cancer mortality (six trials, n=31,930, 1.02; 0.90-1.15, p=0.81). However, a significantly reduced risk was observed for melanoma (three trials, n=19,128, 0.47; 0.23-0.94, p=0.03). Furthermore, higher total cancer incidence risk was observed among those trials with a higher percent use of lipid-lowering drugs (>60%, 1.10; 1.00-1.20, p=0.04), or with lower percent baseline hypertension (70%, 1.08; 1.00-1.16, p=0.057).Consistently, meta-regression analyses suggested that the similar trend between percent use of lipid-lowering drugs (p=0.084) or percent baseline hypertension (p=0.056) and log-RR for total cancer incidence associated with folic acid supplementation. Our findings indicate that folic acid supplementation has no significant effect on total cancer incidence, colorectal cancer, prostate cancer, lung cancer, breast cancer or hematological malignancy, but reduces the risk of melanoma.

语种英语
WOS记录号WOS:000320559600002
项目编号2012CB517703
资助机构Major State Basic Research Development Program of China
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52561
专题北京大学第一临床医学院_药剂科
北京大学第一临床医学院_心血管内科
北京大学临床肿瘤学院_消化肿瘤内科
作者单位1.Southern Med Univ, Nanfang Hosp, Div Nephrol, Guangzhou, Guangdong, Peoples R China
2.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
3.Peking Univ, Dept Pharm, Hosp 1, Beijing 100871, Peoples R China
4.Beijing Univ, Dept Cardiol, Peoples Hosp, Beijing 100871, Peoples R China
5.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Oncol, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
6.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100871, Peoples R China
7.Southern Med Univ, Guangdong Inst Nephrol, Guangzhou, Guangdong, Peoples R China
8.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Ctr Early Life Origins Dis, Baltimore, MD 21205 USA
推荐引用方式
GB/T 7714
Qin, Xianhui,Cui, Yimin,Shen, Lin,et al. Folic acid supplementation and cancer risk: A meta-analysis of randomized controlled trials[J]. INTERNATIONAL JOURNAL OF CANCER,2013,133(5):1033-1041.
APA Qin, Xianhui.,Cui, Yimin.,Shen, Lin.,Sun, Ningling.,Zhang, Yan.,...&Wang, Xiaobin.(2013).Folic acid supplementation and cancer risk: A meta-analysis of randomized controlled trials.INTERNATIONAL JOURNAL OF CANCER,133(5),1033-1041.
MLA Qin, Xianhui,et al."Folic acid supplementation and cancer risk: A meta-analysis of randomized controlled trials".INTERNATIONAL JOURNAL OF CANCER 133.5(2013):1033-1041.
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