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学科主题: 临床医学
题名:
Folic acid supplementation and cancer risk: A meta-analysis of randomized controlled trials
作者: Qin, Xianhui1,2; Cui, Yimin3; Shen, Lin4; Sun, Ningling5; Zhang, Yan6; Li, Jianping6; Xu, Xin7; Wang, Binyan2; Xu, Xiping7; Huo, Yong6; Wang, Xiaobin8
关键词: folic acid supplementation ; cancer risk ; randomized controlled trials ; meta-analysis
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2013-09-01
DOI: 10.1002/ijc.28038
卷: 133, 期:5, 页:1033-1041
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: STAGE RENAL-DISEASE ; CARDIOVASCULAR EVENTS ; MYOCARDIAL-INFARCTION ; COLORECTAL ADENOMAS ; STROKE PREVENTION ; B-VITAMINS ; LOWERING HOMOCYSTEINE ; VASCULAR-DISEASE ; CLINICAL-TRIAL ; MORTALITY
英文摘要:

There are growing data and a continuing controversy over the effect of folic acid supplementation on cancer risk. We conducted a meta-analysis based on up-to-date published relevant randomized trials to further examine this issue. Relative risk (RR) was used to measure the effect of folic acid supplementation on risk of cancer using a random-effects model. Overall, folic acid supplementation had no significant effect on total cancer incidence (13 trials, n=49,406, RR=1.05; 95% CI: 0.99-1.11, p=0.13), colorectal cancer (seven trials, n=33,824, 1.01; 0.82-1.23, p=0.95), other gastrointestinal cancer (two trials, n=20,228, 1.00; 0.75-1.33, p=0.99), prostate cancer (five trials, n=27,065, 1.17; 0.84-1.62, p=0.35), other genitourinary cancer (two trials, n=20,228, 0.97; 0.75-1.27, p=0.84), lung cancer (five trials, n=31,864, 1.00; 0.84-1.21, p=0.97), breast cancer (four trials, n=19,800, 0.82; 0.63-1.07, p=0.15), hematological malignancy (three trials, n=25,670, 0.87; 0.64-1.17, p=0.35) and total cancer mortality (six trials, n=31,930, 1.02; 0.90-1.15, p=0.81). However, a significantly reduced risk was observed for melanoma (three trials, n=19,128, 0.47; 0.23-0.94, p=0.03). Furthermore, higher total cancer incidence risk was observed among those trials with a higher percent use of lipid-lowering drugs (>60%, 1.10; 1.00-1.20, p=0.04), or with lower percent baseline hypertension (70%, 1.08; 1.00-1.16, p=0.057).Consistently, meta-regression analyses suggested that the similar trend between percent use of lipid-lowering drugs (p=0.084) or percent baseline hypertension (p=0.056) and log-RR for total cancer incidence associated with folic acid supplementation. Our findings indicate that folic acid supplementation has no significant effect on total cancer incidence, colorectal cancer, prostate cancer, lung cancer, breast cancer or hematological malignancy, but reduces the risk of melanoma.

语种: 英语
所属项目编号: 2012CB517703
项目资助者: Major State Basic Research Development Program of China
WOS记录号: WOS:000320559600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52561
Appears in Collections:北京大学第一临床医学院_药剂科_期刊论文

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作者单位: 1.Southern Med Univ, Nanfang Hosp, Div Nephrol, Guangzhou, Guangdong, Peoples R China
2.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
3.Peking Univ, Dept Pharm, Hosp 1, Beijing 100871, Peoples R China
4.Beijing Univ, Dept Cardiol, Peoples Hosp, Beijing 100871, Peoples R China
5.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Oncol, Minist Educ,Canc Hosp & Inst, Beijing 100871, Peoples R China
6.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100871, Peoples R China
7.Southern Med Univ, Guangdong Inst Nephrol, Guangzhou, Guangdong, Peoples R China
8.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Ctr Early Life Origins Dis, Baltimore, MD 21205 USA

Recommended Citation:
Qin, Xianhui,Cui, Yimin,Shen, Lin,et al. Folic acid supplementation and cancer risk: A meta-analysis of randomized controlled trials[J]. INTERNATIONAL JOURNAL OF CANCER,2013,133(5):1033-1041.
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