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Development and evaluation of liquid embolic agents based on liquid crystalline material of glyceryl monooleate
Du, Ling-Ran1; Lu, Xiao-Jing1; Guan, Hai-Tao2; Yang, Yong-Jie1; Gu, Meng-Jie1; Zheng, Zhuo-Zhao3; Lv, Tian-Shi2; Yan, Zi-Guang2; Song, Li2; Zou, Ying-Hua2; Fu, Nai-Qi3; Qi, Xian-Rong1; Fan, Tian-Yuan1
关键词Liquid Embolic Agent Glyceryl Monooleate Liquid Crystalline Material Isotropic Liquid Embolization
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2014-08-25
DOI10.1016/j.ijpharm.2014.05.036
471期:1-2页:285-296
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]DRUG-DELIVERY-SYSTEMS ; AQUEOUS MONOOLEIN/POLOXAMER DISPERSIONS ; BUTYL CYANOACRYLATE EMBOLIZATION ; ENHANCED ORAL BIOAVAILABILITY ; VINYL ALCOHOL COPOLYMER ; WATER-SOLUBLE DRUG ; IN-VIVO EVALUATION ; SUSTAINED-RELEASE ; ARTERIOVENOUS-MALFORMATIONS ; ARTERIAL EMBOLIZATION
英文摘要

New type of liquid embolic agents based on a liquid crystalline material of glyceryl monooleate (GMO) was developed and evaluated in this study. Ternary phase diagram of GMO, water and ethanol was constructed and three isotropic liquids (ILs, GMO: ethanol: water = 49: 21: 30, 60: 20: 20 and 72: 18: 10 (w/w/w)) were selected as potential liquid embolic agents, which could spontaneously form viscous gel cast when contacting with water or physiological fluid. The ILs exhibited excellent microcatheter deliverability due to low viscosity, and were proved to successfully block the saline flow when performed in a device to simulate embolization in vitro. The ILs also showed good cytocompatibility on L929 mouse fibroblast cell line. The embolization of ILs to rabbit kidneys was performed successfully under monitoring of digital subtraction angiography (DSA), and embolic degree was affected by the initial formulation composition and used volume. At 5th week after embolization, DSA and computed tomography (CT) confirmed the renal arteries embolized with IL did not recanalize in follow-up period, and an obvious atrophy of the embolized kidney was observed. Therefore, the GMO-based liquid embolic agents showed feasible and effective to embolize, and potential use in clinical interventional embolization therapy. (C) 2014 Elsevier B. V. All rights reserved.

语种英语
WOS记录号WOS:000338423600034
项目编号2009ZX09310-001
资助机构State Key Projects
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52564
专题北京大学药学院
北京大学药学院_药剂学系
北京大学第一临床医学院_介入血管外科
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Dept Intervent Radiol & Vasc Surg, Beijing 100034, Peoples R China
3.Peking Univ, Dept Radiol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Du, Ling-Ran,Lu, Xiao-Jing,Guan, Hai-Tao,et al. Development and evaluation of liquid embolic agents based on liquid crystalline material of glyceryl monooleate[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2014,471(1-2):285-296.
APA Du, Ling-Ran.,Lu, Xiao-Jing.,Guan, Hai-Tao.,Yang, Yong-Jie.,Gu, Meng-Jie.,...&Fan, Tian-Yuan.(2014).Development and evaluation of liquid embolic agents based on liquid crystalline material of glyceryl monooleate.INTERNATIONAL JOURNAL OF PHARMACEUTICS,471(1-2),285-296.
MLA Du, Ling-Ran,et al."Development and evaluation of liquid embolic agents based on liquid crystalline material of glyceryl monooleate".INTERNATIONAL JOURNAL OF PHARMACEUTICS 471.1-2(2014):285-296.
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