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学科主题: 药学
题名:
Development and evaluation of liquid embolic agents based on liquid crystalline material of glyceryl monooleate
作者: Du, Ling-Ran1; Lu, Xiao-Jing1; Guan, Hai-Tao2; Yang, Yong-Jie1; Gu, Meng-Jie1; Zheng, Zhuo-Zhao3; Lv, Tian-Shi2; Yan, Zi-Guang2; Song, Li2; Zou, Ying-Hua2; Fu, Nai-Qi3; Qi, Xian-Rong1; Fan, Tian-Yuan1
关键词: Liquid embolic agent ; Glyceryl monooleate ; Liquid crystalline material ; Isotropic liquid ; Embolization
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2014-08-25
DOI: 10.1016/j.ijpharm.2014.05.036
卷: 471, 期:1-2, 页:285-296
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DRUG-DELIVERY-SYSTEMS ; AQUEOUS MONOOLEIN/POLOXAMER DISPERSIONS ; BUTYL CYANOACRYLATE EMBOLIZATION ; ENHANCED ORAL BIOAVAILABILITY ; VINYL ALCOHOL COPOLYMER ; WATER-SOLUBLE DRUG ; IN-VIVO EVALUATION ; SUSTAINED-RELEASE ; ARTERIOVENOUS-MALFORMATIONS ; ARTERIAL EMBOLIZATION
英文摘要:

New type of liquid embolic agents based on a liquid crystalline material of glyceryl monooleate (GMO) was developed and evaluated in this study. Ternary phase diagram of GMO, water and ethanol was constructed and three isotropic liquids (ILs, GMO: ethanol: water = 49: 21: 30, 60: 20: 20 and 72: 18: 10 (w/w/w)) were selected as potential liquid embolic agents, which could spontaneously form viscous gel cast when contacting with water or physiological fluid. The ILs exhibited excellent microcatheter deliverability due to low viscosity, and were proved to successfully block the saline flow when performed in a device to simulate embolization in vitro. The ILs also showed good cytocompatibility on L929 mouse fibroblast cell line. The embolization of ILs to rabbit kidneys was performed successfully under monitoring of digital subtraction angiography (DSA), and embolic degree was affected by the initial formulation composition and used volume. At 5th week after embolization, DSA and computed tomography (CT) confirmed the renal arteries embolized with IL did not recanalize in follow-up period, and an obvious atrophy of the embolized kidney was observed. Therefore, the GMO-based liquid embolic agents showed feasible and effective to embolize, and potential use in clinical interventional embolization therapy. (C) 2014 Elsevier B. V. All rights reserved.

语种: 英语
所属项目编号: 2009ZX09310-001
项目资助者: State Key Projects
WOS记录号: WOS:000338423600034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52564
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Dept Intervent Radiol & Vasc Surg, Beijing 100034, Peoples R China
3.Peking Univ, Dept Radiol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Du, Ling-Ran,Lu, Xiao-Jing,Guan, Hai-Tao,et al. Development and evaluation of liquid embolic agents based on liquid crystalline material of glyceryl monooleate[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2014,471(1-2):285-296.
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