|Association of Dysglycemia and All-Cause Mortality Across the Spectrum of Coronary Artery Disease|
|Yang, Shi-Wei1; Zhou, Yu-Jie1; Tian, Xiao-Fang2; Pan, Guo-Zhong4; Liu, Yu-Yang1; Zhang, Jian5; Guo, Zhen-Feng6; Chen, Shu-Yan4; Gao, Song-Tao4; Du, Jie1; Jia, De-An1; Fang, Zhe1; Hu, Bin1; Han, Hong-Ya1; Gao, Fei1; Hu, Da-Yi7; Xu, Yu-Yun8; Beijing Heart Metab Survey Study1|
|刊名||MAYO CLINIC PROCEEDINGS|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||ACUTE MYOCARDIAL-INFARCTION ; INTENSIVE INSULIN THERAPY ; CRITICALLY ILL PATIENTS ; DIABETES-MELLITUS ; BLOOD-GLUCOSE ; TASK-FORCE ; PRACTICE GUIDELINES ; ELDERLY-PATIENTS ; FOCUSED UPDATE ; OLDER PATIENTS|
Objective: To assess the association between fasting plasma glucose (FPG) and all-cause mortality across the spectrum of coronary artery disease (CAD).
Patients and Methods: The study included 18,999 patients during a study period of April 1, 2004, through October 31, 2010. The primary end points were in-hospital and follow-up all-cause mortality. According to the quartiles of FPG levels, patients were categorized into 4 groups: quartile 1, less than 5.1 mmol/L; quartile 2, 5.1 to less than 5.9 mmol/L; quartile 3, 5.9 to less than 7.5 mmol/L; and quartile 4, 7.5 mmol/L or greater. The conversion factor for units of plasma glucose is 1.00 mmol/L equals 18 mg/dL. Presented as mg/dL, the 4 quartile ranges of plasma glucose concentrations used in our data analysis are <= 90.0 mg/dL, 90.1-106.0 mg/dL, 106.1 mg/dL-135.0 mg/dL and >= 135.1 mg/dL. Quartile 1 was recognized as the lower glycemic group, quartiles 2 and 3 as the normoglycemic groups, and quartile 4 as the higher glycemic group.
Results: In patients with acute myocardial infarction, all-cause mortality for the dysglycemic groups was higher than for the normoglycemic groups: in-hospital mortality for quartiles 1, 2, 3, and 4 was 1.0%, 0.9%, 0.2%, and 1.5%, respectively (P=.001); follow-up mortality for quartiles 1, 2, 3, and 4 was 1.7%, 0.9%, 0.3%, and 1.8%, respectively (P<.001). In patients with stable CAD, no significant differences in mortality were found among groups. However, in patients with unstable angina pectoris, the normoglycemic groups had lower follow-up mortality and roughly equal in-hospital mortality compared with the dysglycemic groups. After adjusting for confounding factors, this observation persisted.
Conclusion: The association between lower FPG level and mortality differed across the spectrum of CAD. In patients with acute myocardial infarction, there was a U-shaped relationship. In patients with stable CAD or unstable angina pectoris, mildly to moderately decreasing FPG level was associated with neither higher nor lower all-cause mortality. (C) 2013 Mayo Foundation for Medical Education and Research
|项目编号||81100143 ; KZ201110025031 ; Z0005190042811 ; Z121107002512053|
|资助机构||National Natural Science Foundation of China ; Beijing Municipal Education Commission ; Beijing Municipal Science & ; Technology Commission ; Beijing Nova Program|
|作者单位||1.Capital Med Univ, Beijing Inst Heart Lung & Blood Vessel Dis, Minist Educ,Ward 12, Dept Cardiol,Beijing An Zhen Hosp,Key Lab Remodel, Beijing 100029, Peoples R China|
2.Lanzhou Univ, Dept Pharmacol, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Gansu, Peoples R China
3.China Meitan Gen Hosp, Dept Cardiol, Beijing, Peoples R China
4.Hebei United Univ, Tangshan, Heibei, Peoples R China
5.Gen Hosp Beijing Mil Command, Dept Cardiol, Beijing, Peoples R China
6.Nanjing Med Univ, Benq Med Ctr, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
7.Peking Univ Peoples Hosp, Dept Cardiol, Beijing, Peoples R China
8.Peking Univ First Hosp, Dept Cardiol, Beijing, Peoples R China
|Yang, Shi-Wei,Zhou, Yu-Jie,Tian, Xiao-Fang,et al. Association of Dysglycemia and All-Cause Mortality Across the Spectrum of Coronary Artery Disease[J]. MAYO CLINIC PROCEEDINGS,2013,88(9):930-941.|
|APA||Yang, Shi-Wei.,Zhou, Yu-Jie.,Tian, Xiao-Fang.,Pan, Guo-Zhong.,Liu, Yu-Yang.,...&Beijing Heart Metab Survey Study.(2013).Association of Dysglycemia and All-Cause Mortality Across the Spectrum of Coronary Artery Disease.MAYO CLINIC PROCEEDINGS,88(9),930-941.|
|MLA||Yang, Shi-Wei,et al."Association of Dysglycemia and All-Cause Mortality Across the Spectrum of Coronary Artery Disease".MAYO CLINIC PROCEEDINGS 88.9(2013):930-941.|