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学科主题: 药学
题名:
Six insecticidal isoryanodane diterpenoids from the bark and twigs of Itoa orientalis
作者: Chai, Xing-Yun; Bai, Chang-Cai; Shi, Hai-Ming; Xu, Zheng-Ren; Ren, Hong-Yan; Li, Fei-Fei; Lu, Ya-Nan; Song, Yue-Lin; Tu, Peng-Fei
关键词: itols A-D ; isoryanodane glycosides ; Itoa orientalis ; X-ray diffraction ; insecticidal activity
刊名: TETRAHEDRON
发表日期: 2008-06-09
DOI: 10.1016/j.tet.2008.04.022
卷: 64, 期:24, 页:5743-5747
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: PHENOLIC GLYCOSIDES
英文摘要:

Four rare isoryanodane diterpenoids namely itols A-D (1-4) and two isoryanosdane glucosides (5 and 6) were isolated from the bark and twigs of Itoa orientalis. Their structures were determined by NMR and MS techniques and the Structure of 1 was confirmed by a single-crystal X-ray diffraction. These six diterpenoids obviously showed insecticidal activity against Spodoptera exigua, with LC(50) 28.62 ppm for 1 and 52.76 ppm for 2, respectively. In anti-inflammatory assay, compounds 1 and 4-6 showed anti-COX-2 activity, with inhibitory rates of 54.7-78.3% at 10 mu m. (C) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000256335800016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52603
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China

Recommended Citation:
Chai, Xing-Yun,Bai, Chang-Cai,Shi, Hai-Ming,et al. Six insecticidal isoryanodane diterpenoids from the bark and twigs of Itoa orientalis[J]. TETRAHEDRON,2008,64(24):5743-5747.
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