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学科主题基础医学
A Higher Correlation of HCV Core Antigen with CD4+T Cell Counts Compared with HCV RNA in HCV/HIV-1 Coinfected Patients
Shen, Tao1,2; Chen, Xiangmei1,2; Zhang, Weidong3; Xi, Yuanlin3; Cao, Guanghua4; Zhi, Yuhong5; Wang, Shuiwang5; Xu, Chunhui1,2; Wei, Lai6; Lu, Fengmin1,2; Zhuang, Hui1,2
刊名PLOS ONE
2011-08-12
DOI10.1371/journal.pone.0023550
6期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HEPATITIS-C VIRUS ; COMMERCIAL PLASMA DONORS ; RISK-FACTORS ; ANTIRETROVIRAL THERAPY ; LIVER-DISEASE ; BLOOD-DONORS ; ENZYME-IMMUNOASSAY ; INFECTED PATIENTS ; PREVALENCE ; HIV
英文摘要

Development of HCV infection is typically followed by chronic hepatitis C (CHC) in most patients, while spontaneous HCV viral clearance (SVC) occurs in only a minority of subjects. Compared with the widespread application of HCV RNA testing by quantitative RT-PCR technique, HCV core antigen detection may be an alternative indicator in the diagnosis of hepatitis C virus infections and in monitoring the status of infectious individuals. However, the correlation and differences between these two indicators in HCV infection need more investigation, especially in patients coinfected by HIV-1. In this study, a total of 354 anti-HCV and/or anti-HIV serum positive residents from a village of central China were enrolled. Besides HCV-related hepatopathic variables including clinical status, ALT, AST, anti-HCV Abs, as well as the altered CD4+/CD8+ T cell counts, HCV core antigen and HCV viral load were also measured. The concentration of serum HCV core antigen was highly correlated with level of HCV RNA in CHC patients with or without HIV-1 coinfection. Of note, HCV core antigen concentration was negatively correlated with CD4+ T cell count, while no correlation was found between HCV RNA level and CD4+ T cell count. Our findings suggested that quantitative detection of plasma HCV core antigen may be an alternative indicator of HCV RNA qPCR assay when evaluating the association between HCV replication and host immune status in HCV/HIV-1 coinfected patients.

语种英语
WOS记录号WOS:000293953500055
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52605
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Beijing 100871, Peoples R China
3.Zhengzhou Univ, Dept Epidemiol, Coll Publ Hlth, Zhengzhou, Henan, Peoples R China
4.Shangcai Cty Peoples Hosp, Shangcai, Henan, Peoples R China
5.Shangcai Ctr Dis Control & Prevent, Shangcai, Henan, Peoples R China
6.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Shen, Tao,Chen, Xiangmei,Zhang, Weidong,et al. A Higher Correlation of HCV Core Antigen with CD4+T Cell Counts Compared with HCV RNA in HCV/HIV-1 Coinfected Patients[J]. PLOS ONE,2011,6(8).
APA Shen, Tao.,Chen, Xiangmei.,Zhang, Weidong.,Xi, Yuanlin.,Cao, Guanghua.,...&Zhuang, Hui.(2011).A Higher Correlation of HCV Core Antigen with CD4+T Cell Counts Compared with HCV RNA in HCV/HIV-1 Coinfected Patients.PLOS ONE,6(8).
MLA Shen, Tao,et al."A Higher Correlation of HCV Core Antigen with CD4+T Cell Counts Compared with HCV RNA in HCV/HIV-1 Coinfected Patients".PLOS ONE 6.8(2011).
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