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学科主题: 基础医学
题名:
A Higher Correlation of HCV Core Antigen with CD4+T Cell Counts Compared with HCV RNA in HCV/HIV-1 Coinfected Patients
作者: Shen, Tao1,2; Chen, Xiangmei1,2; Zhang, Weidong3; Xi, Yuanlin3; Cao, Guanghua4; Zhi, Yuhong5; Wang, Shuiwang5; Xu, Chunhui1,2; Wei, Lai6; Lu, Fengmin1,2; Zhuang, Hui1,2
刊名: PLOS ONE
发表日期: 2011-08-12
DOI: 10.1371/journal.pone.0023550
卷: 6, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HEPATITIS-C VIRUS ; COMMERCIAL PLASMA DONORS ; RISK-FACTORS ; ANTIRETROVIRAL THERAPY ; LIVER-DISEASE ; BLOOD-DONORS ; ENZYME-IMMUNOASSAY ; INFECTED PATIENTS ; PREVALENCE ; HIV
英文摘要:

Development of HCV infection is typically followed by chronic hepatitis C (CHC) in most patients, while spontaneous HCV viral clearance (SVC) occurs in only a minority of subjects. Compared with the widespread application of HCV RNA testing by quantitative RT-PCR technique, HCV core antigen detection may be an alternative indicator in the diagnosis of hepatitis C virus infections and in monitoring the status of infectious individuals. However, the correlation and differences between these two indicators in HCV infection need more investigation, especially in patients coinfected by HIV-1. In this study, a total of 354 anti-HCV and/or anti-HIV serum positive residents from a village of central China were enrolled. Besides HCV-related hepatopathic variables including clinical status, ALT, AST, anti-HCV Abs, as well as the altered CD4+/CD8+ T cell counts, HCV core antigen and HCV viral load were also measured. The concentration of serum HCV core antigen was highly correlated with level of HCV RNA in CHC patients with or without HIV-1 coinfection. Of note, HCV core antigen concentration was negatively correlated with CD4+ T cell count, while no correlation was found between HCV RNA level and CD4+ T cell count. Our findings suggested that quantitative detection of plasma HCV core antigen may be an alternative indicator of HCV RNA qPCR assay when evaluating the association between HCV replication and host immune status in HCV/HIV-1 coinfected patients.

语种: 英语
所属项目编号: 2008ZX10002-012 ; 2008ZX10002-013 ; 2009ZX10004-903
项目资助者: National Science and Technology Major Project for Infectious Diseases
WOS记录号: WOS:000293953500055
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52605
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Beijing 100871, Peoples R China
3.Zhengzhou Univ, Dept Epidemiol, Coll Publ Hlth, Zhengzhou, Henan, Peoples R China
4.Shangcai Cty Peoples Hosp, Shangcai, Henan, Peoples R China
5.Shangcai Ctr Dis Control & Prevent, Shangcai, Henan, Peoples R China
6.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100871, Peoples R China

Recommended Citation:
Shen, Tao,Chen, Xiangmei,Zhang, Weidong,et al. A Higher Correlation of HCV Core Antigen with CD4+T Cell Counts Compared with HCV RNA in HCV/HIV-1 Coinfected Patients[J]. PLOS ONE,2011,6(8).
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