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学科主题: 临床医学
题名:
Efficacy and safety of autologous fibroblast (FB) seeded biodegradable scaffold for rabbit penile girth enlargement
作者: Wu, Yi Guang; Jin, Zhe; Xin, Zhong Cheng; Song, Wei Dong; Peng, Jing; Zhang, Zhi Chao; Gao, Bing; Mm, Ze Long
关键词: biodegradable scaffold ; fibroblast (FB) ; penis enlargement
刊名: TISSUE ENGINEERING AND REGENERATIVE MEDICINE
发表日期: 2007-12-01
卷: 4, 期:4, 页:551-556
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell & Tissue Engineering ; Engineering, Biomedical
研究领域[WOS]: Cell Biology ; Engineering
关键词[WOS]: GREEN FLUORESCENT PROTEIN
英文摘要:

The purpose of this experiment is to construct an in vitro model of rabbit penis enlargement using tissue engineering method, and to investigate the efficacy and safety of autologous fibroblast cell seeded to biodegradable scaffold and also to provide a new perspective of clinical application. We observed the growth of GFP transgenic fibroblast cell from SD mouse after transplantation with the biodegradable scaffold by fluorescence microscope. At the second hand, 160 male New Zealand rabbits were divided into four groups; Group A for control; Group B for acellular matrix implanted; Group C for scaffold implanted only; Group D for autologous cultured fibroblast seeded scaffold. Rabbit scrotal skin (4 x 4 mm) was detached under general anesthesia, and fibroblast (FB) was cultured and proliferated for 2weeks. Cultured cells were seeded into the scaffold and inserted on the between buck′s and dartos fascia of rabbit penis. To assess the efficacy and safety of the cells, we observed for 4months. The FB of rabbit were successfully cultured and confirmed by immunohistochemistry method. In the results of group D, dermal cell seeding group, the penile girth was significantly increased to 22.3% compared to other groups (Group A 0.3%, Group B 12.7%, Group C 14.6% and Group D 22.3%). We checked the results in 2 similar to 4 months later. We observed that moderate penile girth increase was gained using the biodegradable scaffold without other side-effects. Therefore, we carefully suggest a new guidance for penile augmentation by the tissue engineering method.

语种: 英语
WOS记录号: WOS:000258567500010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52606
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: Peking Univ, Androl Ctr, First Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Wu, Yi Guang,Jin, Zhe,Xin, Zhong Cheng,et al. Efficacy and safety of autologous fibroblast (FB) seeded biodegradable scaffold for rabbit penile girth enlargement[J]. TISSUE ENGINEERING AND REGENERATIVE MEDICINE,2007,4(4):551-556.
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