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Efficacy and safety of autologous fibroblast (FB) seeded biodegradable scaffold for rabbit penile girth enlargement
Wu, Yi Guang; Jin, Zhe; Xin, Zhong Cheng; Song, Wei Dong; Peng, Jing; Zhang, Zhi Chao; Gao, Bing; Mm, Ze Long
关键词Biodegradable Scaffold Fibroblast (Fb) Penis Enlargement
刊名TISSUE ENGINEERING AND REGENERATIVE MEDICINE
2007-12-01
4期:4页:551-556
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell & Tissue Engineering ; Engineering, Biomedical
研究领域[WOS]Cell Biology ; Engineering
关键词[WOS]GREEN FLUORESCENT PROTEIN
英文摘要

The purpose of this experiment is to construct an in vitro model of rabbit penis enlargement using tissue engineering method, and to investigate the efficacy and safety of autologous fibroblast cell seeded to biodegradable scaffold and also to provide a new perspective of clinical application. We observed the growth of GFP transgenic fibroblast cell from SD mouse after transplantation with the biodegradable scaffold by fluorescence microscope. At the second hand, 160 male New Zealand rabbits were divided into four groups; Group A for control; Group B for acellular matrix implanted; Group C for scaffold implanted only; Group D for autologous cultured fibroblast seeded scaffold. Rabbit scrotal skin (4 x 4 mm) was detached under general anesthesia, and fibroblast (FB) was cultured and proliferated for 2weeks. Cultured cells were seeded into the scaffold and inserted on the between buck′s and dartos fascia of rabbit penis. To assess the efficacy and safety of the cells, we observed for 4months. The FB of rabbit were successfully cultured and confirmed by immunohistochemistry method. In the results of group D, dermal cell seeding group, the penile girth was significantly increased to 22.3% compared to other groups (Group A 0.3%, Group B 12.7%, Group C 14.6% and Group D 22.3%). We checked the results in 2 similar to 4 months later. We observed that moderate penile girth increase was gained using the biodegradable scaffold without other side-effects. Therefore, we carefully suggest a new guidance for penile augmentation by the tissue engineering method.

语种英语
WOS记录号WOS:000258567500010
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52606
专题北京大学第一临床医学院_男科中心
北京大学第一临床医学院_泌尿外科
北京大学第一临床医学院_呼吸科
作者单位Peking Univ, Androl Ctr, First Hosp, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wu, Yi Guang,Jin, Zhe,Xin, Zhong Cheng,et al. Efficacy and safety of autologous fibroblast (FB) seeded biodegradable scaffold for rabbit penile girth enlargement[J]. TISSUE ENGINEERING AND REGENERATIVE MEDICINE,2007,4(4):551-556.
APA Wu, Yi Guang.,Jin, Zhe.,Xin, Zhong Cheng.,Song, Wei Dong.,Peng, Jing.,...&Mm, Ze Long.(2007).Efficacy and safety of autologous fibroblast (FB) seeded biodegradable scaffold for rabbit penile girth enlargement.TISSUE ENGINEERING AND REGENERATIVE MEDICINE,4(4),551-556.
MLA Wu, Yi Guang,et al."Efficacy and safety of autologous fibroblast (FB) seeded biodegradable scaffold for rabbit penile girth enlargement".TISSUE ENGINEERING AND REGENERATIVE MEDICINE 4.4(2007):551-556.
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