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学科主题: 临床医学
题名:
Thyroid dysfunction in Chinese hepatitis C patients: Prevalence and correlation with TPOAb and CXCL10
作者: Zhang, Ren-Wen; Shao, Cui-Ping; Huo, Na; Li, Min-Ran; Xi, Hong-Li; Yu, Min; Xu, Xiao-Yuan
关键词: Thyroid dysfunction ; Thyroid peroxidase antibody ; CXC chemokine ligand 10 ; Peginterferon alfa2a/ribavirin ; China
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2015-09-07
DOI: 10.3748/wjg.v21.i33.9765
卷: 21, 期:33, 页:9765-9773
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: RIBAVIRIN COMBINATION THERAPY ; INTERFERON-ALPHA THERAPY ; AUTOIMMUNE-THYROIDITIS ; VIRUS-INFECTION ; HYPOTHYROIDISM ; DISEASE ; RISK ; HYPERTHYROIDISM ; ANTINUCLEAR ; POPULATION
英文摘要:

AIM: To investigate the relationship among pretreatment serum CXC chemokine ligand 10 (CXCL10), thyroid peroxidase antibody (TPOAb) levels and thyroid dysfunction (TD) in Chinese hepatitis C patients.

METHODS: One hundred and thirty-nine treatmentnaive genotype 1 chronic hepatitis C patients with no history of TD or treatment with thyroid hormones were enrolled in this study. Patients underwent peginterferon alfa-2a/ribavirin (PegIFN alpha-2a/RBV) treatment for 48 wk, followed by detection of clinical factors at each follow-up point. Hepatitis C virus (HCV) antibodies were analyzed using microsomal chemiluminescence, and serum HCV RNA was measured by real-time PCR assay at 0, 4, 12, 24 and 48 wk after the initiation of therapy and 24 wk after the end of therapy. To assess thyroid function, serum thyroid stimulating hormone (TSH), free thyroxine (FT4), free triodothyronine (FT3) and TPOAb/thyroglobulin antibody (TGAb) levels were determined using chemiluminescent immunoassays every 3 mo. Serum CXCL10 levels were determined at baseline.

RESULTS: The prevalence of TD was 18.0%. Twentyone (84.0%) out of twenty-five patients exhibited normal thyroid function at week 24 after therapy. The rate of sustained virological response to PegIFN alpha-2a/RBV in our study was 59.0% (82/139), independent of thyroid function. Pretreatment serum CXCL10 levels were significantly increased in patients with euthyroid status compared with patients with TD (495.2 +/- 244.2 pg/mL vs 310.0 +/- 163.4 pg/mL, P = 0.012). Patients with TD were more frequently TPOAb-positive than non-TD (NTD) patients (24.2% vs 12.3%, P = 0.047) at baseline. Three of the one hundred and fifteen patients without TPOAb at baseline developed TD at the end of treatment (37.5% vs 2.6%, P = 0.000). Female patients exhibited an increased risk for developing TD compared with male patients (P = 0.014).

CONCLUSION: Lower pretreatment serum CXCL10 levels are associated with TD, and TD prevalence increases in female patients and patients who are positive for TPOAb at baseline.

语种: 英语
所属项目编号: 2012ZX10002003-004-003 ; 81373056 ; 20090001110081
项目资助者: National Major Project for Infectious Diseases Control ; National Natural Science Foundation of China ; PhD Program Foundation of Ministry of Education of China
WOS记录号: WOS:000360933500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52607
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: Peking Univ, Dept Infect Dis, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Ren-Wen,Shao, Cui-Ping,Huo, Na,et al. Thyroid dysfunction in Chinese hepatitis C patients: Prevalence and correlation with TPOAb and CXCL10[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2015,21(33):9765-9773.
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