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学科主题临床医学
Excessive Intrauterine Fluid Cause Aberrant Implantation and Pregnancy Outcome in Mice
Lu, Shan1; Peng, Hongying2; Zhang, He2; Zhang, Li2; Cao, Qichen2; Li, Rong1,3,4; Zhang, Ying2; Yan, Liying1; Duan, Enkui2; Qiao, Jie1,3,4
刊名PLOS ONE
2013-10-23
DOI10.1371/journal.pone.0078446
8期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]IN-VITRO FERTILIZATION ; UTERINE LUMINAL FLUID ; EMBRYO IMPLANTATION ; ENDOMETRIAL RECEPTIVITY ; ASSISTED REPRODUCTION ; HYDROSALPINX ; IVF ; SALPINGECTOMY ; EXPRESSION ; WOMEN
英文摘要

The normal intrauterine fluid environment is essential for embryo implantation. In hydrosalpinx patients, the implantation and pregnancy rates are markedly decreased after IVF-embryo transfer, while salpingectomy could significantly improve the pregnancy rates. The leakage of hydrosalpinx fluid into the endometrial cavity was supposed to be the major cause for impaired fertility. However, the underlying mechanisms of hydrosalpinx fluids on implantation and ongoing pregnancy were not fully understood and remain controversial regarding its toxicity. In present study, by infusing different volume of non-toxic fluid (0.9% saline) into uterine lumen before embryo implantation in mice (Day4 08: 30), we found that while the embryos were not "flushed out" from the uteri, the timing of implantation was deferred and normal intrauterine distribution (embryo spacing) was disrupted. The abnormal implantation at early pregnancy further lead to embryo growth retardation, miscarriage and increased pregnancy loss, which is similar to the adverse effects observed in hydrosalpinx patients undergoing IVF-ET. We further examined uterine receptivity related gene expression reported to be involved in human hydrosalpinx (Lif, Hoxa10, Integrin a(v) and beta(3)). The results showed that expression of integrin alpha(v) and beta(3) were increased in the fluid infused mouse uteri, implicating a compensatory effect to cope with the excessive fluid environment. Our data suggested that the adverse effects of excessive non-toxic luminal fluid on pregnancy are primarily due to the mechanical interference for normal timing and location of embryo apposition, which might be the major cause of decreased implantation rate in IVF-ET patients with hydrosalpinx.

语种英语
WOS记录号WOS:000326037000113
项目编号81000275 ; 31300957 ; 31300960 ; 2011CB944503 ; 2011CB944401
资助机构National Natural Science Foundation of China ; National Basic Research Program of China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52608
专题北京大学第三临床医学院
北京大学第三临床医学院_生殖医学中心
作者单位1.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
2.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing, Peoples R China
4.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Lu, Shan,Peng, Hongying,Zhang, He,et al. Excessive Intrauterine Fluid Cause Aberrant Implantation and Pregnancy Outcome in Mice[J]. PLOS ONE,2013,8(10).
APA Lu, Shan.,Peng, Hongying.,Zhang, He.,Zhang, Li.,Cao, Qichen.,...&Qiao, Jie.(2013).Excessive Intrauterine Fluid Cause Aberrant Implantation and Pregnancy Outcome in Mice.PLOS ONE,8(10).
MLA Lu, Shan,et al."Excessive Intrauterine Fluid Cause Aberrant Implantation and Pregnancy Outcome in Mice".PLOS ONE 8.10(2013).
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