北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 流行病学研究室  > 期刊论文
学科主题: 临床医学
题名:
Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention
作者: Feng, Guo-Shuang1; Ma, Jun-Ling1; Wong, Benjamin C. Y.2; Zhang, Lian1; Liu, Wei-Dong5; Pan, Kai-Feng1; Shen, Lin3; Zhang, Xiao-Dong3; Li, Jie3; Xia, Harry H. X.2; Li, Ji-You4; Lam, Shiu Kum2; You, Wei-Cheng1
关键词: celecoxib ; gastroduodenal ulcer ; cardiovascular diseases ; adverse effects ; epidemiology ; randomized controlled trial
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2008-07-28
DOI: 10.3748/wjg.14.4535
卷: 14, 期:28, 页:4535-4539
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: RHEUMATOID-ARTHRITIS ; COX-2 INHIBITORS ; GASTROINTESTINAL TOXICITY ; RISK ; ROFECOXIB ; CYCLOOXYGENASE-2 ; OSTEOARTHRITIS ; NSAIDS ; POPULATION ; DICLOFENAC
英文摘要:

AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.

METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted.

RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no significant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was significantly higher in patients treated with celecoxib than in those treated with placebo.

CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. (C) 2008 The WJG Press. All rights reserved.

语种: 英语
WOS记录号: WOS:000258263500017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52612
Appears in Collections:北京大学临床肿瘤学院_流行病学研究室_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Healthy Bur Linqu Cty, Weifang 262600, Shandong, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Canc Epidemiol, Beijing 100036, Peoples R China
3.Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Med Oncol, Beijing 100036, Peoples R China
5.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100036, Peoples R China

Recommended Citation:
Feng, Guo-Shuang,Ma, Jun-Ling,Wong, Benjamin C. Y.,et al. Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(28):4535-4539.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Feng, Guo-Shuang]'s Articles
[Ma, Jun-Ling]'s Articles
[Wong, Benjamin C. Y.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Feng, Guo-Shuang]‘s Articles
[Ma, Jun-Ling]‘s Articles
[Wong, Benjamin C. Y.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace