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学科主题: 临床医学
题名:
Expression and clinical significance of c-Met in advanced esophageal squamous cell carcinoma
作者: Xu, Yingying1; Peng, Zhi1; Li, Zhongwu1,2; Lu, Ming1; Gao, Jing1; Li, Yilin1; Li, Yanyan1; Shen, Lin1
关键词: Esophageal squamous cell carcinoma ; c-Met ; Chemotherapy ; Overall survival
刊名: BMC CANCER
发表日期: 2015-01-15
DOI: 10.1186/s12885-014-1001-3
卷: 15
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: COLORECTAL-CANCER ; GASTRIC-CANCER ; BREAST-CANCER ; LUNG-CANCER ; RECEPTOR ; RESISTANCE ; AMPLIFICATION ; OVEREXPRESSION ; ADENOCARCINOMA ; ACTIVATION
英文摘要:

Background: c-Met, one of current potential hot targets, has been suggested as a potential tumor marker in the development of esophageal squamous cell carcinoma (ESCC). Our aim was to investigate the expression of c-Met in advanced esophageal squamous cell carcinoma in four phase II trials who had tumor tissues from archival in our center and analyze the correlations between c-Met expression and clinical features.

Methods: Ninety patients with advanced ESCC who were admitted to the phase II clinical trials in the Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute from March 2007 to March 2014 were finally eligible for present study and the corresponding tissues and clinical data were collected. The expression of c-Met in the tissue samples was detected by immunohistochemistry (IHC). c-Met overexpression was defined as >= the median value of H-score. Kaplan-Meier and Cox multivariate regression were conducted to evaluate the relationship between c-Met expression and ESCC survival.

Results: The overexpression of c-Met is 43.3% in advanced ESCC. There was no statistical difference between c-Met expression and clinical features except sex and tumor location. Survival analysis documented that the overexpression of c-Met predicted a worse prognosis (OS: 253 d vs 422 d, P = 0.011). In the group treated with chemotherapy combined with anti-EGFR drugs, patients with lowexpression of c-Met had a better OS than those with overexpression of c-Met (OS: 577 d vs 232 d, P = 0.007).

Conclusions: c-Met may be an independent prognostic factor in advanced ESCC. The overexpression of c-Met may predict a worse efficacy of anti-EGFR therapy.

语种: 英语
所属项目编号: 81172110 ; 2012AA02A504 ; Z11110706730000 ; 7142034 ; 2013 M530494
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program ; Beijing Municipal Science &amp ; Technology Commission Program ; Beijing Natural Science Foundation ; China Postdoctoral Science Foundation
WOS记录号: WOS:000348812200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52613
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Yingying,Peng, Zhi,Li, Zhongwu,et al. Expression and clinical significance of c-Met in advanced esophageal squamous cell carcinoma[J]. BMC CANCER,2015,15.
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