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学科主题: 基础医学
题名:
Potential role of plasmacytoid dendritic cells for FOXP3(+) regulatory T cell development in human colorectal cancer and tumor draining lymph node
作者: Gai, Xiao Dong1; Song, Yang1; Li, Chun1; Lei, Yan Ming2; Yang, Baoxue3,4
关键词: Colorectal cancer ; Tumor draining lymph nodes ; Regulatory T cells ; Plasmacytoid dentritic cells ; Immunohistochemistry
刊名: PATHOLOGY RESEARCH AND PRACTICE
发表日期: 2013
DOI: 10.1016/j.prp.2013.08.011
卷: 209, 期:12, 页:774-778
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: OVARIAN-CANCER ; LUNG-CANCER ; LYMPHOCYTES ; GENERATION ; IMMUNITY ; SCURFIN ; SUBSET ; LIGAND ; MOUSE ; STAGE
英文摘要:

FOXP3(+) regulatory T cells (Tregs) play an important role in the maintenance of tumor immunity tolerance. Compared with conventional myeloid dentritic cells (mDCs), plasmacytoid dendritic cells (pDCs) exhibit poor immunostimulatory ability, and their interaction with T cells often promotes the development of Tregs. The aim of this study was to determine FOXP3(+) Tregs and CD123(+) pDCs infiltration in colorectal cancer and tumor draining lymph node (TDLN), and to evaluate the clinical significance and relationship between pDCs infiltration and Tregs development in the CRC tolerogenic milieu. An immunohistochemical assay was conducted to assess FOXP3+Tregs and CD123(+) pDCs infiltration in tumor tissue and in metastatic-free TDLN (mfTDLN) and metastatic TDLN (mTDLN). The results showed that F0XP3(+) Tregs infiltration was more frequent in tumor tissue than in adjacent normal mucosa (P< 0.001). FOXP3(+) Tregs infiltration was associated with advanced TNM stage and lymph node metastasis (P< 0.01 and P< 0.01 for TNM stage and lymph node metastasis, respectively). Different from FOXP3(+)Tregs, CD1231(+) pDCs frequencies were lower in most CRC tumor tissues, whereas the positive rate of CD123 expression in CRC was significantly higher than in adjacent normal mucosa tissue (P< 0.01). Compared to mfTDLN, mTDLN was significantly enriched in FOXP3(+) Tregs (P< 0.01) and increased in pDC/mDC ratio (P< 0.01). The statistical analysis demonstrated a significant correlation in both Tregs and pDC/mDC ratio in mTDLN. These results suggest that there are more FOXP3(+) Tregs with a stronger prognostic significance which might promote tumor tolerance, and that CD123(+) pDCs might contribute to Tregs development in the CRC tolerogenic milieu. (C) 2013 Elsevier GmbH. All rights reserved.

语种: 英语
所属项目编号: 2011151 ; 201262501 ; 81170632
项目资助者: Department of Education of Jilin Province ; Science And Technology Project of Jilin city ; National Natural Science Foundation of China
WOS记录号: WOS:000327915400004
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52614
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Gen Hosp CNPC Jilin, Dept Pathol, Fengman, Jilin, Peoples R China
2.State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
3.Beihua Univ, Dept Pathol, Sch Basic Med Sci, Fengman 132013, Jilin, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100871, Peoples R China

Recommended Citation:
Gai, Xiao Dong,Song, Yang,Li, Chun,et al. Potential role of plasmacytoid dendritic cells for FOXP3(+) regulatory T cell development in human colorectal cancer and tumor draining lymph node[J]. PATHOLOGY RESEARCH AND PRACTICE,2013,209(12):774-778.
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