IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats
Chen, Siyao1; Zheng, Saijun2; Liu, Zhiwei2; Tang, Chaoshu3,4; Zhao, Bin2; Du, Junbao1,4; Jin, Hongfang1
刊名LABORATORY INVESTIGATION
2015-02-01
DOI10.1038/labinvest.2014.147
95期:2页:142-156
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pathology
研究领域[WOS]Research & Experimental Medicine ; Pathology
关键词[WOS]RESPIRATORY-DISTRESS-SYNDROME ; INDUCED MYOCARDIAL INJURY ; PHOSPHOINOSITIDE HYDROLYSIS ; CARDIOVASCULAR-SYSTEM ; CASPASE-3 ACTIVATION ; GUINEA-PIGS ; HYPEROXIA ; MICE ; PATHOGENESIS ; GLUTATHIONE
英文摘要

The role of endogenous sulfur dioxide (SO2), an efficient gasotransmitter maintaining homeostasis, in the development of acute lung injury (ALI) remains unidentified. We aimed to investigate the role of endogenous SO2 in the pathogenesis of ALI. An oleic acid (OA)-induced ALI rat model was established. Endogenous SO2 levels, lung injury, oxidative stress markers and apoptosis were examined. OA-induced ALI rats showed a markedly downregulated endogenous SO2/aspartate aminotransferase 1 (AAT1)/AAT2 pathway and severe lung injury. Chemical colorimetry assays demonstrated upregulated reactive oxygen species generation and downregulated antioxidant capacity in OA-induced ALI rats. However, SO2 increased endogenous SO2 levels, protected against oxidative stress and alleviated ALI. Moreover, compared with OA-treated cells, in human alveolar epithelial cells SO2 downregulated O-2(-) and O-H(-) generation. In contrast, L-aspartic acid-beta-hydroxamate (HDX, Sigma-Aldrich Corporation), an inhibitor of endogenous SO2 generating enzyme, promoted free radical generation, upregulated poly (ADP-ribose) polymerase expression, activated caspase-3, as well as promoted cell apoptosis. Importantly, apoptosis could be inhibited by the free radical scavengers glutathione (GSH) and N-acetyl-L-cysteine (NAC). The results suggest that SO2/AAT1/AAT2 pathway might protect against the development of OA-induced ALI by inhibiting oxidative stress.

语种英语
WOS记录号WOS:000348636900003
项目编号31130030 ; 91439110 ; 31440052 ; 2012CB517806 ; 2011CB503904
资助机构National Natural Science Foundation of China ; Major Basic Research Development Program of People&prime ; s Republic of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52616
专题北京大学第一临床医学院_儿科
作者单位1.Beijing Jishuitan Hosp, Dept Emergency, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
4.Minist Educ, Dept Gasotransmitters & Cardiovasc Dis, Key Lab Mol Cardiol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Chen, Siyao,Zheng, Saijun,Liu, Zhiwei,et al. Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats[J]. LABORATORY INVESTIGATION,2015,95(2):142-156.
APA Chen, Siyao.,Zheng, Saijun.,Liu, Zhiwei.,Tang, Chaoshu.,Zhao, Bin.,...&Jin, Hongfang.(2015).Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats.LABORATORY INVESTIGATION,95(2),142-156.
MLA Chen, Siyao,et al."Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats".LABORATORY INVESTIGATION 95.2(2015):142-156.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Siyao]的文章
[Zheng, Saijun]的文章
[Liu, Zhiwei]的文章
百度学术
百度学术中相似的文章
[Chen, Siyao]的文章
[Zheng, Saijun]的文章
[Liu, Zhiwei]的文章
必应学术
必应学术中相似的文章
[Chen, Siyao]的文章
[Zheng, Saijun]的文章
[Liu, Zhiwei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。