IR@PKUHSC  > 北京大学临床肿瘤学院  > 病理科
学科主题临床医学
Colorectal cancer or colon and rectal cancer?
Li, M.1; Li, J. Y.2; Zhao, A. L.2; Gu, J.1
关键词Colon Cancer Rectal Cancer Carcinoembryonic Antigen Matrix Metalloproteinase 2 P27(Kip1)
刊名ONCOLOGY
2007
DOI10.1159/000120628
73期:1-2页:52-57
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CARCINOEMBRYONIC ANTIGEN ; PROGNOSTIC-SIGNIFICANCE ; CARCINOMA CELLS ; EXPRESSION ; TISSUE ; CEA
英文摘要

Aims: The aim of this study was to compare features of colon and rectal cancers such as prognosis, clinicopathological features and tumor markers, namely carcinoembryonic antigen (CEA), matrix metalloproteinase (MMP)-2 and p27(kip1). Methods: Two hundred and thirty patients with stage I-III colon or rectal cancer were retrospectively assessed with the endpoint of recurrence or metastasis after curative operation. CEA, MMP-2 and p27(kip1) were studied by immunohistochemistry in cancer tissues of all patients. Results: The disease-free 3-year survival rate after operation of the total 230 patients was 63.0%. The prognosis of colon cancer was significantly better than that of rectal cancer (70.6 vs. 57.0%; p = 0.017), especially for stage III (p = 0.0059). Multivariate analysis also demonstrated that tumor location in the colon or rectum, differentiation, venous invasion and the expression of CEA were independent factors for prognosis. The hazard of recurrence and metastasis in rectal cancer was 1.564 times that in colon cancer. In both groups, there were no statistical differences in age, gender, tumor size, tumor gross type, mucin production, tumor differentiation, venous invasion, MMP-2 and p27(kip1). Conclusion: We investigated prognosis, clinicopathological factors, oncogenes and tumor suppressor gene production in colon and rectal cancers. The prognosis of colon cancer is better than that of rectal cancer, especially for stage III. This study shows some differences between colon and rectal cancer. Copyright (C) 2008 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000254740600008
引用统计
被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52619
专题北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Sch Med, Beijing Canc Hosp & Inst, Gastrointestinal Surg Unit, Beijing 100036, Peoples R China
2.Peking Univ, Sch Med, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714
Li, M.,Li, J. Y.,Zhao, A. L.,et al. Colorectal cancer or colon and rectal cancer?[J]. ONCOLOGY,2007,73(1-2):52-57.
APA Li, M.,Li, J. Y.,Zhao, A. L.,&Gu, J..(2007).Colorectal cancer or colon and rectal cancer?.ONCOLOGY,73(1-2),52-57.
MLA Li, M.,et al."Colorectal cancer or colon and rectal cancer?".ONCOLOGY 73.1-2(2007):52-57.
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