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学科主题: 临床医学
题名:
Colorectal cancer or colon and rectal cancer?
作者: Li, M.1; Li, J. Y.2; Zhao, A. L.2; Gu, J.1
关键词: colon cancer ; rectal cancer ; carcinoembryonic antigen ; matrix metalloproteinase 2 ; p27(kip1)
刊名: ONCOLOGY
发表日期: 2007
DOI: 10.1159/000120628
卷: 73, 期:1-2, 页:52-57
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CARCINOEMBRYONIC ANTIGEN ; PROGNOSTIC-SIGNIFICANCE ; CARCINOMA CELLS ; EXPRESSION ; TISSUE ; CEA
英文摘要:

Aims: The aim of this study was to compare features of colon and rectal cancers such as prognosis, clinicopathological features and tumor markers, namely carcinoembryonic antigen (CEA), matrix metalloproteinase (MMP)-2 and p27(kip1). Methods: Two hundred and thirty patients with stage I-III colon or rectal cancer were retrospectively assessed with the endpoint of recurrence or metastasis after curative operation. CEA, MMP-2 and p27(kip1) were studied by immunohistochemistry in cancer tissues of all patients. Results: The disease-free 3-year survival rate after operation of the total 230 patients was 63.0%. The prognosis of colon cancer was significantly better than that of rectal cancer (70.6 vs. 57.0%; p = 0.017), especially for stage III (p = 0.0059). Multivariate analysis also demonstrated that tumor location in the colon or rectum, differentiation, venous invasion and the expression of CEA were independent factors for prognosis. The hazard of recurrence and metastasis in rectal cancer was 1.564 times that in colon cancer. In both groups, there were no statistical differences in age, gender, tumor size, tumor gross type, mucin production, tumor differentiation, venous invasion, MMP-2 and p27(kip1). Conclusion: We investigated prognosis, clinicopathological factors, oncogenes and tumor suppressor gene production in colon and rectal cancers. The prognosis of colon cancer is better than that of rectal cancer, especially for stage III. This study shows some differences between colon and rectal cancer. Copyright (C) 2008 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000254740600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52619
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Sch Med, Beijing Canc Hosp & Inst, Gastrointestinal Surg Unit, Beijing 100036, Peoples R China
2.Peking Univ, Sch Med, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100036, Peoples R China

Recommended Citation:
Li, M.,Li, J. Y.,Zhao, A. L.,et al. Colorectal cancer or colon and rectal cancer?[J]. ONCOLOGY,2007,73(1-2):52-57.
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