IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Bridging small-gap peripheral nerve defects using biodegradable chitin conduits with cultured Schwann and bone marrow stromal cells in rats
Zhang, PX1; He, XJ1; Zhao, FQ1; Zhang, DY1; Fu, ZG1; Jiang, BG1
关键词Nerve Regeneration Bone Marrow Stromal Cells Conduits
刊名JOURNAL OF RECONSTRUCTIVE MICROSURGERY
2005-11-01
21期:8页:565-571
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]REGENERATION ; GRAFTS ; REPAIR ; FUSION
英文摘要

Nerve regeneration requires not only an autologous, allogenous, or biodegradable scaffolding, but additional interactions with regeneration-promoting Schwann cells. Considering the pluripotency of bone marrow stromal cells into different lineages, the authors compared biodegradable conduits with the application of cultured Schwann cells and bone marrow stromal cells in a rat sciatic injury model. Simple conduit bridging served as controls. Electrophysiologic evaluation and histologic morphometrical analysis were performed after 6 weeks; both groups With cultured cells showed a statistically significantly higher number of axons, more well-shaped remyelinated axons, and an advance in clinical functional recovery (SFI) than the simple conduit-bridging group. Confocal microscopy found that bone marrow stromal cells adopted the Schwarm-cell phenotype, expressing S100 protein. Considering the ease of aspiration and greater resource of bone marrow stromal cells, the implantation of a biodegradable conduit with cultured bone marrow stromal cells was capable of presenting an alternative to conduits with Schwann cells for bridging nerve defects.

语种英语
WOS记录号WOS:000233478300009
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52621
Collection北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Orthopaed & Trauma, Beijing 1000444, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Orthopaed & Trauma, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhang, PX,He, XJ,Zhao, FQ,et al. Bridging small-gap peripheral nerve defects using biodegradable chitin conduits with cultured Schwann and bone marrow stromal cells in rats[J]. JOURNAL OF RECONSTRUCTIVE MICROSURGERY,2005,21(8):565-571.
APA Zhang, PX,He, XJ,Zhao, FQ,Zhang, DY,Fu, ZG,&Jiang, BG.(2005).Bridging small-gap peripheral nerve defects using biodegradable chitin conduits with cultured Schwann and bone marrow stromal cells in rats.JOURNAL OF RECONSTRUCTIVE MICROSURGERY,21(8),565-571.
MLA Zhang, PX,et al."Bridging small-gap peripheral nerve defects using biodegradable chitin conduits with cultured Schwann and bone marrow stromal cells in rats".JOURNAL OF RECONSTRUCTIVE MICROSURGERY 21.8(2005):565-571.
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