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学科主题: 公共卫生
题名:
The Impact of Lipid-metabolizing Genetic Polymorphisms on Body Mass Index and Their Interactions with Soybean Food Intake: A Study in a Chinese Population
作者: Wang Jin Wei1; Tang Xun1; Li Na2; Wu Yi Qun1; Li Shuai1; Li Jin1; Qin Xue Ying1; Zhang Zong Xin3; Hu Yong Hua1; Chen Da Fang1
关键词: Body mass index ; Lipid metabolism ; Genetic epidemiology ; Haplotypes ; Gene-environment interaction
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2014-03-01
DOI: 10.3967/bes2014.039
卷: 27, 期:3, 页:176-185
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: CORONARY-ARTERY-DISEASE ; CARDIOVASCULAR-DISEASE ; HAPLOTYPE BLOCKS ; HUMAN GENOME ; OBESITY ; RISK ; LOCI ; ASSOCIATION ; INDIVIDUALS ; CHOLESTEROL
英文摘要:

Objective To evaluate the association of known polymorphisms in the lipid metabolic pathway with body mass index (BMI), and estimate their interactions with soybean food intake.

Methods A community-based cross-sectional survey was conducted in a Chinese Han population. BMI, soybean food intake, and single nucleotide polymorphisms of rs599839, rs3846662, rs3846663, rs12916, rs174547, rs174570, rs4938303, and rs1558861 were measured in 944 subjects. A multivariate logistic regression was used to analyze the association of the studied polymorphisms with BMIs. The expectation-maximization algorithm was employed to evaluate the extent of linkage disequilibrium between pairwise polymorphisms. The gene-environment interaction was assessed in the general multifactor dimensionality reduction model.

Results The polymorphisms of rs3846662 and rs3846663 were associated with 10% highest BMIs when comparing to the 10% lowest values both in individuals and haplotype-based association tests. Although no statistically significant gene-environment interactions were found, people with the haplotype composed of C allele in rs3846662 and T allele in rs3846663 and low frequency of soybean intake had significantly higher risk to overweight and obesity as compared with those with the haplotype consisting of T allele in rs3846662 and C allele in rs3846663 and highly frequent soybean food intake, with an odds ratio of 1.64 (95% confidence interval: 1.15-2.34, P<0.01) after adjusting for the common confounders.

Conclusion Our study has suggested that rs3846662 and rs3846663 may be the potential candidate polymorphisms for obesity, and their effect on the pathogenesis could be mediated by the frequency of soybean food intake.

语种: 英语
所属项目编号: 2006CB503903 ; 811727 !E e-search?query1=81230066&field1=identifier&advanced=false">81230066
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
WOS记录号: WOS:000334933300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52623
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Fangshan Dist Bur Hlth, Beijing 102401, Peoples R China
2.First Hosp Fangshan Dist, Beijing 102400, Peoples R China
3.Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Wang Jin Wei,Tang Xun,Li Na,et al. The Impact of Lipid-metabolizing Genetic Polymorphisms on Body Mass Index and Their Interactions with Soybean Food Intake: A Study in a Chinese Population[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2014,27(3):176-185.
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