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Neuroprotective effects of erigeron breviscapus (vant.) hand -mazz on glaucoma-A multi -center clinical trial
Wang, Ning-Li1; Sun, Xing-Huai2; Li, Jing-Zhen3; Wang, Jing-Hua4; Chen, Xiao-Ming5; Lin, Ding1; Lue, Jian-Hua6; Zhong, Yi-Sheng7; Zhang, Chun8; Guo, Wen-Yi2
关键词Erigeron Breviscapus (Vant.) Hand-mazz Glaucoma Neuroprotection
刊名INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2008-09-18
1期:3页:247-252
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
英文摘要

AIM: To evaluate the neuroprotective effects of a Chinese herbal drug, erigeron breviscapus (vant.) hand-mazz (EBHM), on glaucoma patients with controlled intraocular pressure (TOP) after surgical and/or medical therapies.

METHODS: A total of 99 primary glaucoma patients (113 eyes) with medically or surgically controlled IOP were given orally either EBHM or placebo for 6 months and then evaluated in a multi-center, prospective, randomized and double masked clinical trial by quantifying the visual field changes using visual field defect scoring (VFDS).

RESULTS: After 2, 4, 6 months of treatment, the VFDS in EBHM Group (66 eyes/55 patients) decreased by 0.44+/-1.60, 1.27+/-2.16 and 1.42+/-2.37 respectively, indicating a time-dependent improvement of visual field upon EBHM treatment, whereas the VFDS in Placebo Control Group (47 eyes/47 patients) decreased by -0.02+/-1.5, 0.68+/-1.73 and 0.40+/-1.57 respectively. Statistically, the differences of VFDS between the two groups were significant (P<0.05) at 2 and 4 months, and highly significant at 6 months of treatment (P= 0.007). The average IOP in both groups was 15mmHg (range 8-18mmHg) during the period of the study (P>0.05). No serious side effects were reported in glaucoma patients on EBHM.

CONCLUSION: EBHM appeared to be safe and effective in neuroprotection for patients with glaucoma. More studies are needed to determine the safety and effectiveness of longer-term EBHM treatment.

语种英语
WOS记录号WOS:000207682500013
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52626
专题北京大学第三临床医学院_眼科
作者单位1.Xingtai Ophthalm Hosp, Xingtai 054001, Hebei Province, Peoples R China
2.Peking Univ, Ctr Eye, Hosp 3, Beijing 100083, Peoples R China
3.Beijing Tongren Hosp, Ctr Eye, Beijing 100730, Peoples R China
4.Fudan Univ, Dept Ophthalmol, Shanghai Eye & ENT Hosp, Shanghai 200031, Peoples R China
5.Beijing Union Med Coll Hosp, Dept Ophthalmol, Beijing 100730, Peoples R China
6.Qingdao Univ, Dept Ophthalmol, Affiliated Hosp, Coll Med, Qingdao 266003, Shandong, Peoples R China
7.Sichuan Univ, W China Hosp, Dept Ophthalmol, Chengdu 610041, Sichuan Prov, Peoples R China
8.Shanghai Med Univ 2, Ruijin Hosp, Dept Ophthalmol, Shanghai 200025, Peoples R China
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GB/T 7714
Wang, Ning-Li,Sun, Xing-Huai,Li, Jing-Zhen,et al. Neuroprotective effects of erigeron breviscapus (vant.) hand -mazz on glaucoma-A multi -center clinical trial[J]. INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,2008,1(3):247-252.
APA Wang, Ning-Li.,Sun, Xing-Huai.,Li, Jing-Zhen.,Wang, Jing-Hua.,Chen, Xiao-Ming.,...&Guo, Wen-Yi.(2008).Neuroprotective effects of erigeron breviscapus (vant.) hand -mazz on glaucoma-A multi -center clinical trial.INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,1(3),247-252.
MLA Wang, Ning-Li,et al."Neuroprotective effects of erigeron breviscapus (vant.) hand -mazz on glaucoma-A multi -center clinical trial".INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 1.3(2008):247-252.
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