北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 眼科  > 期刊论文
学科主题: 临床医学
题名:
Neuroprotective effects of erigeron breviscapus (vant.) hand -mazz on glaucoma-A multi -center clinical trial
作者: Wang, Ning-Li1; Sun, Xing-Huai2; Li, Jing-Zhen3; Wang, Jing-Hua4; Chen, Xiao-Ming5; Lin, Ding1; Lue, Jian-Hua6; Zhong, Yi-Sheng7; Zhang, Chun8; Guo, Wen-Yi2
关键词: erigeron breviscapus (vant.) hand-mazz ; glaucoma ; neuroprotection
刊名: INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
发表日期: 2008-09-18
卷: 1, 期:3, 页:247-252
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
英文摘要:

AIM: To evaluate the neuroprotective effects of a Chinese herbal drug, erigeron breviscapus (vant.) hand-mazz (EBHM), on glaucoma patients with controlled intraocular pressure (TOP) after surgical and/or medical therapies.

METHODS: A total of 99 primary glaucoma patients (113 eyes) with medically or surgically controlled IOP were given orally either EBHM or placebo for 6 months and then evaluated in a multi-center, prospective, randomized and double masked clinical trial by quantifying the visual field changes using visual field defect scoring (VFDS).

RESULTS: After 2, 4, 6 months of treatment, the VFDS in EBHM Group (66 eyes/55 patients) decreased by 0.44+/-1.60, 1.27+/-2.16 and 1.42+/-2.37 respectively, indicating a time-dependent improvement of visual field upon EBHM treatment, whereas the VFDS in Placebo Control Group (47 eyes/47 patients) decreased by -0.02+/-1.5, 0.68+/-1.73 and 0.40+/-1.57 respectively. Statistically, the differences of VFDS between the two groups were significant (P<0.05) at 2 and 4 months, and highly significant at 6 months of treatment (P= 0.007). The average IOP in both groups was 15mmHg (range 8-18mmHg) during the period of the study (P>0.05). No serious side effects were reported in glaucoma patients on EBHM.

CONCLUSION: EBHM appeared to be safe and effective in neuroprotection for patients with glaucoma. More studies are needed to determine the safety and effectiveness of longer-term EBHM treatment.

语种: 英语
WOS记录号: WOS:000207682500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52626
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Xingtai Ophthalm Hosp, Xingtai 054001, Hebei Province, Peoples R China
2.Peking Univ, Ctr Eye, Hosp 3, Beijing 100083, Peoples R China
3.Beijing Tongren Hosp, Ctr Eye, Beijing 100730, Peoples R China
4.Fudan Univ, Dept Ophthalmol, Shanghai Eye & ENT Hosp, Shanghai 200031, Peoples R China
5.Beijing Union Med Coll Hosp, Dept Ophthalmol, Beijing 100730, Peoples R China
6.Qingdao Univ, Dept Ophthalmol, Affiliated Hosp, Coll Med, Qingdao 266003, Shandong, Peoples R China
7.Sichuan Univ, W China Hosp, Dept Ophthalmol, Chengdu 610041, Sichuan Prov, Peoples R China
8.Shanghai Med Univ 2, Ruijin Hosp, Dept Ophthalmol, Shanghai 200025, Peoples R China

Recommended Citation:
Wang, Ning-Li,Sun, Xing-Huai,Li, Jing-Zhen,et al. Neuroprotective effects of erigeron breviscapus (vant.) hand -mazz on glaucoma-A multi -center clinical trial[J]. INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,2008,1(3):247-252.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Ning-Li]'s Articles
[Sun, Xing-Huai]'s Articles
[Li, Jing-Zhen]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Ning-Li]‘s Articles
[Sun, Xing-Huai]‘s Articles
[Li, Jing-Zhen]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace