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学科主题: 临床医学
题名:
The ameliorating effects of long-term electroacupuncture on cardiovascular remodeling in spontaneously hypertensive rats
作者: Huo, Ze-Jun1,2,3; Li, Quan2; Tian, Gui-Hua2,3; Zhou, Chang-Man4; Wei, Xiao-Hong2; Pan, Chun-Shui2; Yang, Lei4; Bai, Yan5,6; Zhang, You-Yi5,6; He, Ke2; Wang, Chuan-She2,7; Li, Zhi-Gang3; Han, Jing-Yan2,7
关键词: Cardiac hypertrophy ; Electroacupuncture ; Angiotensin II type 1 receptor ; Endothelin-1 ; Endothelin-1 type A receptor ; NO
刊名: BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2014-04-01
DOI: 10.1186/1472-6882-14-118
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: VENTRICULAR HYPERTROPHY ; PRESSURE-OVERLOAD ; ANGIOTENSIN-II ; EXPRESSION ; FIBROSIS ; HEART ; ENDOTHELIN-1 ; ACUPUNCTURE ; DEFICIENCY ; ACTIVATION
英文摘要:

Background: The purpose of this study was to investigate the inhibitory effects of long-term electroacupuncture at BaiHui (DU20) and ZuSanLi (ST36) on cardiovascular remodeling in spontaneously hypertensive rats (SHR) and underlying mechanisms.

Methods: 6-weeks-old SHR or Wistar male rats were randomly, divided into 6 groups: the control group (SHR/Wistar), the non-acupoint electroacupuncture stimulation group (SHR-NAP/Wistar-NAP) and the electroacupuncture stimulation at DU20 and ST36 group (SHR-AP/Wistar-AP), 24 rats in each group. Rats were treated with or without electroacupuncture at DU20 and ST36, once every other day for a period of 8 weeks. The mean arterial pressure (MAP) was measured once every 2 weeks. By the end of the 8th week, the left ventricular structure and function were assessed by echocardiography. The content of angiotensin II (Ang II), endothelin-1 (ET-1) and nitric oxide (NO) in the plasma was determined using enzyme-linked immunosorbent assay. Histological studies on the heart and the ascending aorta were performed. The expression of angiotensin II type 1 receptor (AT1R), endothelin-1 type A receptor (ETAR), eNOS and iNOS in rat myocardium and ascending aorta was investigated by Western blotting.

Results: The MAP in SHR increased linearly over the observation period and significantly reduced following electroacupuncture as compared with sham control SHR rats, while no difference in MAP was observed in Wistar rats between electroacupuncture and sham control. The aortic wall thickness, cardiac hypertrophy and increased collagen level in SHR were attenuated by long term electroacupuncture. The content of Ang II, ET-1 in the plasma decreased, but the content of NO increased after electroacupuncture stimulation in SHR. Long term electroacupuncture significantly inhibited the expression of AT1R, ETAR and iNOS, whereas increased eNOS expression, in myocardium and ascending aorta of SHR.

Conclusions: The long term electroacupuncture stimulation at DU20 and ST36 relieves the increased MAP and cardiovascular abnormality in both structure and function in SHR, this beneficial action is most likely mediated via modulation of AT1R-AT1R-ET-1-ETAR and NOS/NO pathway.

语种: 英语
所属项目编号: 2008ZX09401
项目资助者: Production of New Medicine Program of Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000334468500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52631
Appears in Collections:北京大学第三临床医学院_中医科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Tradit Chinese Med, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100871, Peoples R China
3.Beijing Univ Chinese Med, Sch Acupuncture & Moxibust, Beijing 100029, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Anat, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100871, Peoples R China
6.Chinese Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
7.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China

Recommended Citation:
Huo, Ze-Jun,Li, Quan,Tian, Gui-Hua,et al. The ameliorating effects of long-term electroacupuncture on cardiovascular remodeling in spontaneously hypertensive rats[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,14.
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